dc.contributor.author | Hals, Ingrid Kathrin | |
dc.contributor.author | Björklund, Anneli | |
dc.contributor.author | Fleiner, Hanne Fiskvik | |
dc.contributor.author | Grill, Valdemar Erik Robert | |
dc.date.accessioned | 2023-03-30T12:20:39Z | |
dc.date.available | 2023-03-30T12:20:39Z | |
dc.date.created | 2022-01-19T14:06:28Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Cytokine. 2022, 151, 155792 | en_US |
dc.identifier.issn | 1043-4666 | |
dc.identifier.uri | https://hdl.handle.net/11250/3061182 | |
dc.description.abstract | Background - Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been conclusively resolved.
Aim - We compared the time course of cytokines/chemokines in Latent Autoimmune Diabetes in Adults (LADA) patients heterogeneous for high or low autoimmune activity as determined by levels of antibodies against glutamic acid decarboxylase (GADA).
Methods - Serum samples to be measured were from a two-armed randomized controlled trial (RCT) in 68 LADA patients. The study encompassed 21 months with C-peptide as primary endpoint. We measured 27 immune mediators at baseline, at 9 and at 21 months (end of study). Results of measurements were analyzed by multiple linear regression.
Results - At baseline, a high body mass index (BMI) (>26 kg/m2) was associated with elevated levels of the interleukins (IL) IL-1 beta, IL-1ra, IL-2, IL-5, IL-6 and IL-13. Treatment during RCT (sitagliptin vs. insulin) did not affect the time course (21 months) of levels of cytokines/chemokines (by univariate analyses). However, levels of the cytokines IL-1ra and IL-1 beta decreased significantly (p < 0.04 or less) in patients with high vs. low GADA when adjusted for BMI, age, gender (male/female), treatment (insulin/sitagliptin) and study site (Norwegian/Swedish).
Conclusions - In LADA, high levels of GADA, a proxy for high autoimmune activity and linked to a decline in C-peptide, was associated with a decrease of selected cytokines over time. This implies that the decline of IL-1ra and IL-1 beta in the circulation reflects autoimmune activity and beta cell demise in LADA. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL1-ra and IL-1 beta is associated with progressive disease | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.volume | 151 | en_US |
dc.source.journal | Cytokine | en_US |
dc.identifier.doi | 10.1016/j.cyto.2022.155792 | |
dc.identifier.cristin | 1984891 | |
dc.source.articlenumber | 155792 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |