dc.contributor.author | Liu, Tengzhi | |
dc.contributor.author | Redalen, Kathrine | |
dc.contributor.author | Karlsen, Morten | |
dc.date.accessioned | 2023-03-06T14:08:50Z | |
dc.date.available | 2023-03-06T14:08:50Z | |
dc.date.created | 2022-04-29T15:17:34Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Journal of labelled compounds & radiopharmaceuticals. 2022, 65 (7), 191-202. | en_US |
dc.identifier.issn | 0362-4803 | |
dc.identifier.uri | https://hdl.handle.net/11250/3056143 | |
dc.description.abstract | Cyclotron-produced copper-64 radioisotope tracers offer the possibility to perform both diagnostic investigation by positron emission tomography (PET) and radiotherapy by a theranostic approach with bifunctional chelators. The versatile chemical properties of copper add to the importance of this isotope in medicinal investigation. [64Cu][Cu (ATSM)] has shown to be a viable candidate for imaging of tumor hypoxia; a critical tumor microenvironment characteristic that typically signifies tumor progression and resistance to chemo-radiotherapy. Various production and radiosynthesis methods of [64Cu][Cu (ATSM)] exist in labs, but usually involved non-standardized equipment with varying production qualities and may not be easily implemented in wider hospital settings. [64Cu][Cu (ATSM)] was synthesized on a modified GE TRACERlab FXN automated synthesis module. End-of-synthesis (EOS) molar activity of [64Cu][Cu (ATSM)] was 2.2–5.5 Ci/μmol (HPLC), 2.2–2.6 Ci/μmol (ATSM-titration), and 3.0–4.4 Ci/μmol (ICP-MS). Radiochemical purity was determined to be >99% based on radio-HPLC. The final product maintained radiochemical purity after 20 h. We demonstrated a simple and feasible process development and quality control protocols for automated cyclotron production and synthesis of [64Cu][Cu (ATSM)] based on commercially distributed standardized synthesis modules suitable for PET imaging and theranostic studies. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | John Wiley & Sons Ltd. | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Development of an automated production process of [<sup>64</sup>Cu][Cu (ATSM)] for positron emission tomography imaging and theranostic applications | en_US |
dc.title.alternative | Development of an automated production process of [<sup>64</sup>Cu][Cu (ATSM)] for positron emission tomography imaging and theranostic applications | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 191-202 | en_US |
dc.source.volume | 65 | en_US |
dc.source.journal | Journal of labelled compounds & radiopharmaceuticals | en_US |
dc.source.issue | 7 | en_US |
dc.identifier.doi | 10.1002/jlcr.3973 | |
dc.identifier.cristin | 2020191 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |