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dc.contributor.authorKristoffersen, Per Martin
dc.contributor.authorVetti, Nils
dc.contributor.authorGrøvle, Lars
dc.contributor.authorBrox, Jens Ivar
dc.contributor.authorBråten, Lars Christian Haugli
dc.contributor.authorGrotle, Margreth
dc.contributor.authorHaugen, Anne Julsrud
dc.contributor.authorRolfsen, Mads Peder
dc.contributor.authorFroholdt, Anne
dc.contributor.authorSkouen, Jan Sture
dc.contributor.authorLutro, Olav
dc.contributor.authorMarchand, Gunn Hege
dc.contributor.authorAnke, Audny Gabriele Wagner
dc.contributor.authorZwart, John Anker Henrik
dc.contributor.authorStorheim, Kjersti
dc.contributor.authorAssmus, Jörg
dc.contributor.authorEspeland, Ansgar
dc.date.accessioned2023-02-28T14:41:56Z
dc.date.available2023-02-28T14:41:56Z
dc.date.created2022-10-31T17:07:42Z
dc.date.issued2022
dc.identifier.citationSPINE. 2022, 48 (3), 147-154en_US
dc.identifier.issn0362-2436
dc.identifier.urihttps://hdl.handle.net/11250/3054752
dc.description.abstractStudy Design - Exploratory subgroup analyses of a randomised trial [Antibiotics in Modic changes (AIM) study]. Objective - The aim was to assess the effect of amoxicillin versus placebo in reducing Modic change (MC) edema in patients with chronic low back pain. Summary of Background Data - The AIM study showed a small, clinically insignificant effect of amoxicillin on pain-related disability in patients with chronic low back pain and MC type 1 (edema type) on magnetic resonance imaging (MRI). Materials and Methods - A total of 180 patients were randomised to receive 100 days of amoxicillin or placebo. MC edema was assessed on MRI at baseline and one-year follow-up. Per-protocol analyses were conducted in subgroups with MC edema on short tau inversion recovery (STIR) or T1/T2-weighted MRI at baseline. MC edema reductions (yes/no) in STIR and T1/T2 series were analyzed separately. The effect of amoxicillin in reducing MC edema was analyzed using logistic regression adjusted for prior disk surgery. To assess the effect of amoxicillin versus placebo within the group with the most abundant MC edema on STIR at baseline (“STIR3” group), we added age, STIR3 (yes/no), and STIR3×treatment group (interaction term) as independent variables and compared the marginal means (probabilities of edema reduction). Results - Compared to placebo, amoxicillin did not reduce MC edema on STIR (volume/intensity) in the total sample with edema on STIR at baseline (odds ratio 1.0, 95% CI: 0.5, 2.0; n=141) or within the STIR3 group (probability of edema reduction 0.69, 95% CI: 0.47, 0.92 with amoxicillin and 0.61, 95% CI: 0.43, 0.80 with placebo; n=41). Compared with placebo, amoxicillin did not reduce MC edema in T1/T2 series (volume of the type 1 part of MCs) (odds ratio: 1.0, 95% CI: 0.5, 2.3, n=104). Edema declined in >50% of patients in both treatment groups. Conclusions - From baseline to one-year follow-up, amoxicillin did not reduce MC edema compared with placebo.en_US
dc.language.isoengen_US
dc.publisherWolters Kluweren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleAmoxicillin did not Reduce Modic Change Oedema in Patients with Chronic Low Back pain - subgroup Analyses of a Randomised Trial (the AIM study)en_US
dc.title.alternativeAmoxicillin did not Reduce Modic Change Oedema in Patients with Chronic Low Back pain - subgroup Analyses of a Randomised Trial (the AIM study)en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber147-154en_US
dc.source.volume48en_US
dc.source.journalSpineen_US
dc.source.issue3en_US
dc.identifier.doi10.1097/BRS.0000000000004513
dc.identifier.cristin2067015
cristin.ispublishedtrue
cristin.fulltextpostprint
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cristin.fulltextoriginal
cristin.qualitycode2


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal