Vis enkel innførsel

dc.contributor.authorStokke, Kristin
dc.contributor.authorHalvorsen, Tarje Onsøien
dc.contributor.authorGrønberg, Bjørn Henning
dc.contributor.authorSaltvedt, Ingvild
dc.contributor.authorJordhøy, Marit Slaaen
dc.contributor.authorKirkevold, Øyvind
dc.contributor.authorKillingberg, Kristin Toftaker
dc.contributor.authorSandvei, Marie Søfteland
dc.date.accessioned2023-02-20T11:58:44Z
dc.date.available2023-02-20T11:58:44Z
dc.date.created2022-05-25T08:54:51Z
dc.date.issued2022
dc.identifier.issn2227-9032
dc.identifier.urihttps://hdl.handle.net/11250/3052329
dc.description.abstractBackground: There is a lack of tools for selecting patients with advanced lung cancer who benefit the most from systemic treatment. Patient-reported physical function (PRPF) has been identified as a prognostic factor in this setting, but little is known about the prognostic value in advanced non-small-cell lung cancer (NSCLC). The aim of this study was to investigate if measured physical performance was an independent or stronger prognostic factor than PRPF in patients with advanced NSCLC receiving platinum-doublet chemotherapy. Methods: We analyzed patients from a randomized trial comparing immediate and delayed pemetrexed therapy in stage III/IV NSCLC (n = 232) who performed timed up and go (TUG) and 5 m walk test (5 mWT) and reported physical function on the EORTC QLQ-C30 before chemotherapy commenced. Results: Overall, 208 patients performed TUG and 5 mWT and were included in the present study. Poor physical function was significantly associated with poor survival (TUG: HR 1.05, p < 0.01, 5 mWT: HR 1.05, p = 0.03, PRPF: 1.01, p < 0.01), but only PRPF remained an independent prognostic factor in multivariable analyses adjusting for baseline characteristics (HR 1.01, p = 0.03). Conclusions: Patient-reported, but not measured, physical performance was an independent prognostic factor for survival in patients with advanced NSCLC receiving platinum-doublet chemotherapy.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAssociations between Measured and Patient-Reported Physical Function and Survival in Advanced NSCLCen_US
dc.title.alternativeAssociations between Measured and Patient-Reported Physical Function and Survival in Advanced NSCLCen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.volume10en_US
dc.source.journalHealthcareen_US
dc.source.issue5en_US
dc.identifier.doi10.3390/healthcare10050922
dc.identifier.cristin2027172
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal