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dc.contributor.authorVesterbekkmo, Elisabeth Kleivhaug
dc.contributor.authorMadssen, Erik
dc.contributor.authorAksetøy, Inger-Lise Aamot
dc.contributor.authorFollestad, Turid
dc.contributor.authorNilsen, Hans-Olav
dc.contributor.authorHegbom, Knut
dc.contributor.authorWisløff, Ulrik
dc.contributor.authorWiseth, Rune
dc.date.accessioned2023-02-13T12:37:27Z
dc.date.available2023-02-13T12:37:27Z
dc.date.created2022-08-29T13:59:13Z
dc.date.issued2022
dc.identifier.citationJournal of the American Heart Association (JAHA). 2022, 11 (10), .en_US
dc.identifier.issn2047-9980
dc.identifier.urihttps://hdl.handle.net/11250/3050394
dc.description.abstractBackground The effect of physical exercise on lipid content of coronary artery plaques is unknown. With near infrared spectroscopy we measured the effect of high intensity interval training (HIIT) on lipid content in coronary plaques in patients with stable coronary artery disease following percutaneous coronary intervention. Methods and Results In CENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near‐Infrared Spectroscopy) 60 patients were randomized to 6 months supervised HIIT or to a control group. The primary end point was change in lipid content measured as maximum lipid core burden index at 4 mm (maxLCBI4mm). A predefined cutoff of maxLCBI4mm >100 was required for inclusion in the analysis. Forty‐nine patients (HIIT=20, usual care=29) had maxLCBI4mm >100 at baseline. Change in maxLCBI4mm did not differ between groups (−1.2, 95% CI, −65.8 to 63.4, P=0.97). The estimated reduction in maxLCBI4mm was −47.7 (95% CI, −100.3 to 5.0, P=0.075) and −46.5 (95% CI, −87.5 to −5.4, P=0.027) after HIIT and in controls, respectively. A negative correlation was observed between change in peak oxygen uptake (VO2peak) and change in lipid content (Spearman’s correlation −0.44, P=0.009). With an increase in VO2peak above 1 metabolic equivalent task, maxLCBI4mm was on average reduced by 142 (−8 to −262), whereas the change was −3.2 (154 to −255) with increased VO2peak below 1 metabolic equivalent task. Conclusions Six months of HIIT following percutaneous coronary intervention did not reduce lipid content in coronary plaques compared with usual care. A moderate negative correlation between increase in VO2peak and change in lipid content generates the hypothesis that exercise with a subsequent increase in fitness may reduce lipid content in coronary atheromatous plaques.en_US
dc.language.isoengen_US
dc.publisherAmerican Heart Associationen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleCENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near-Infrared Spectroscopy): A Randomized Trialen_US
dc.title.alternativeCENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near-Infrared Spectroscopy): A Randomized Trialen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber0en_US
dc.source.volume11en_US
dc.source.journalJournal of the American Heart Association (JAHA)en_US
dc.source.issue10en_US
dc.identifier.doi10.1161/JAHA.121.024705
dc.identifier.cristin2046773
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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