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dc.contributor.authorJohannessen, Knut
dc.contributor.authorBerntsen, Erik Magnus
dc.contributor.authorJohansen, Håkon
dc.contributor.authorSolheim, Tora S
dc.contributor.authorKarlberg, Anna Maria
dc.contributor.authorEikenes, Live
dc.identifier.citationEuropean Journal of Hybrid Imaging. 2021, 5 (1), 1-12.en_US
dc.description.abstractAbstract Background: Patients with metastatic cancer to the brain have a poor prognosis. In clinical practice, MRI is used to delineate, diagnose and plan treatment of brain metastases. However, MRI alone is limited in detecting micro-metastases, delineating lesions and discriminating progression from pseudo-progression. Combined PET/MRI utilises superior soft tissue images from MRI and metabolic data from PET to evaluate tumour structure and function. The amino acid PET tracer 18F-FACBC has shown promising results in discriminating high- and low-grade gliomas, but there are currently no reports on its use on brain metastases. This is the first study to evaluate the use of 18F-FACBC on brain metastases. Case presentation: A middle-aged female patient with brain metastases was evaluated using hybrid PET/MRI with 18F-FACBC before and after stereotactic radiotherapy, and at suspicion of recurrence. Static/dynamic PET and contrastenhanced T1 MRI data were acquired and analysed. This case report includes the analysis of four 18F-FACBC PET/MRI examinations, investigating their utility in evaluating functional and structural metastasis properties. Conclusion: Analysis showed high tumour-to-background ratios in brain metastases compared to other amino acid PET tracers, including high uptake in a very small cerebellar metastasis, suggesting that 18F-FACBC PET can provide early detection of otherwise overlooked metastases. Further studies to determine a threshold for 18F-FACBC brain tumour boundaries and explore its utility in clinical practice should be performed.en_US
dc.publisherSpringer Openen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.title18F-FACBC PET/MRI in the evaluation of human brain metastases: a case reporten_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalEuropean Journal of Hybrid Imagingen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal