dc.contributor.author | Johannessen, Knut | |
dc.contributor.author | Berntsen, Erik Magnus | |
dc.contributor.author | Johansen, Håkon | |
dc.contributor.author | Solheim, Tora S | |
dc.contributor.author | Karlberg, Anna Maria | |
dc.contributor.author | Eikenes, Live | |
dc.date.accessioned | 2021-10-28T11:01:15Z | |
dc.date.available | 2021-10-28T11:01:15Z | |
dc.date.created | 2021-08-18T16:45:00Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | European Journal of Hybrid Imaging. 2021, 5 (1), 1-12. | en_US |
dc.identifier.issn | 2510-3636 | |
dc.identifier.uri | https://hdl.handle.net/11250/2826266 | |
dc.description.abstract | Abstract Background: Patients with metastatic cancer to the brain have a poor prognosis. In clinical practice, MRI is used to delineate, diagnose and plan treatment of brain metastases. However, MRI alone is limited in detecting micro-metastases, delineating lesions and discriminating progression from pseudo-progression. Combined PET/MRI utilises superior soft tissue images from MRI and metabolic data from PET to evaluate tumour structure and function. The amino acid PET tracer 18F-FACBC has shown promising results in discriminating high- and low-grade gliomas, but there are currently no reports on its use on brain metastases. This is the first study to evaluate the use of 18F-FACBC on brain metastases. Case presentation: A middle-aged female patient with brain metastases was evaluated using hybrid PET/MRI with 18F-FACBC before and after stereotactic radiotherapy, and at suspicion of recurrence. Static/dynamic PET and contrastenhanced T1 MRI data were acquired and analysed. This case report includes the analysis of four 18F-FACBC PET/MRI examinations, investigating their utility in evaluating functional and structural metastasis properties. Conclusion: Analysis showed high tumour-to-background ratios in brain metastases compared to other amino acid PET tracers, including high uptake in a very small cerebellar metastasis, suggesting that 18F-FACBC PET can provide early detection of otherwise overlooked metastases. Further studies to determine a threshold for 18F-FACBC brain tumour boundaries and explore its utility in clinical practice should be performed. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer Open | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | 18F-FACBC PET/MRI in the evaluation of human brain metastases: a case report | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 1-12 | en_US |
dc.source.volume | 5 | en_US |
dc.source.journal | European Journal of Hybrid Imaging | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.1186/s41824-021-00101-6 | |
dc.identifier.cristin | 1927051 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |