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dc.contributor.authorMajewska, Paulina Luiza
dc.contributor.authorSagberg, Lisa Millgård
dc.contributor.authorReinertsen, Ingerid
dc.contributor.authorGulati, Sasha
dc.contributor.authorJakola, Asgeir Store
dc.contributor.authorSolheim, Ole
dc.date.accessioned2021-10-22T08:34:47Z
dc.date.available2021-10-22T08:34:47Z
dc.date.created2021-05-07T23:20:38Z
dc.date.issued2021
dc.identifier.issn0001-6314
dc.identifier.urihttps://hdl.handle.net/11250/2824913
dc.description.abstractObjective To determine the diagnostic accuracy of routine clinico-radiological workup for a population-based selection of intracranial tumours. Methods In this prospective cohort study, we included consecutive adult patients who underwent a primary surgical intervention for a suspected intracranial tumour between 2015 and 2019 at a single-neurosurgical centre. The treating team estimated the expected diagnosis prior to surgery using predefined groups. The expected diagnosis was compared to final histopathology and the accuracy of preoperative clinico-radiological diagnosis (sensitivity, specificity, positive and negative predictive values) was calculated. Results 392 patients were included in the data analysis, of whom 319 underwent a primary surgical resection and 73 were operated with a diagnostic biopsy only. The diagnostic accuracy varied between different tumour types. The overall sensitivity, specificity and diagnostic mismatch rate of clinico-radiological diagnosis was 85.8%, 97.7% and 4.0%, respectively. For gliomas (including differentiation between low-grade and high-grade gliomas), the same diagnostic accuracy measures were found to be 82.2%, 97.2% and 5.6%, respectively. The most common diagnostic mismatch was between low-grade gliomas, high-grade gliomas and metastases. Accuracy of 90.2% was achieved for differentiation between diffuse low-grade gliomas and high-grade gliomas. Conclusions The current accuracy of a preoperative clinico-radiological diagnosis of brain tumours is high. Future non-invasive diagnostic methods need to outperform our results in order to add much value in a routine clinical setting in unselected patients.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleWhat is the current clinico-radiological diagnostic accuracy for intracranial tumours?en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.journalActa Neurologica Scandinavicaen_US
dc.identifier.doi10.1111/ane.13430
dc.identifier.cristin1908885
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
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