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dc.contributor.authorZatula, Alexey
dc.contributor.authorDikic, Aida
dc.contributor.authorMulder, Teska Celine
dc.contributor.authorSharma, Animesh
dc.contributor.authorVågbø, Cathrine Broberg
dc.contributor.authorSousa, Mirta
dc.contributor.authorWaage, Anders
dc.contributor.authorSlupphaug, Geir
dc.identifier.citationOncoTarget. 2017, 8 (12), 19427-19442.en_US
dc.description.abstractPlasma cell leukemia is a rare and aggressive plasma cell neoplasm that may either originate de novo (primary PCL) or by leukemic transformation of multiple myeloma (MM) to secondary PCL (sPCL). The prognosis of sPCL is very poor, and currently no standard treatment is available due to lack of prospective clinical studies. In an attempt to elucidate factors contributing to transformation, we have performed super-SILAC quantitative proteome profiling of malignant plasma cells collected from the same patient at both the MM and sPCL stages of the disease. 795 proteins were found to be differentially expressed in the MM and sPCL samples. Gene ontology analysis indicated a metabolic shift towards aerobic glycolysis in sPCL as well as marked down-regulation of enzymes involved in glycan synthesis, potentially mediating altered glycosylation of surface receptors. There was no significant change in overall genomic 5-methylcytosine or 5-hydroxymethylcytosine at the two stages, indicating that epigenetic dysregulation was not a major driver of transformation to sPCL. The present study constitutes the first attempt to provide a comprehensive map of the altered protein expression profile accompanying transformation of MM to sPCL in a single patient, identifying several candidate proteins that can be targeted by currently available small molecule drugs. Our dataset furthermore constitutes a reference dataset for further proteomic analysis of sPCL transformation.en_US
dc.publisherImpact Journalsen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleProteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemiaen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.relation.projectNotur/NorStore: NS9036Ken_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal