dc.contributor.author | Jansen, Iris E. | |
dc.contributor.author | Savage, Jeanne E. | |
dc.contributor.author | Watanabe, Kyoko | |
dc.contributor.author | Bryois, Julien | |
dc.contributor.author | Williams, Dylan M. | |
dc.contributor.author | Steinberg, Stacy | |
dc.contributor.author | Sealock, Julia | |
dc.contributor.author | Karlsson, Ida K. | |
dc.contributor.author | Hägg, Sara | |
dc.contributor.author | Athanasiu, Lavinia | |
dc.contributor.author | Voyle, Nicola | |
dc.contributor.author | Proitsi, Petroula | |
dc.contributor.author | Witoelar, Aree | |
dc.contributor.author | Stringer, Sven | |
dc.contributor.author | Aarsland, Dag | |
dc.contributor.author | Almdahl, Ina Selseth | |
dc.contributor.author | Andersen, Fred | |
dc.contributor.author | Bergh, Sverre | |
dc.contributor.author | Bettella, Francesco | |
dc.contributor.author | Björnsson, Sigurbjörn | |
dc.contributor.author | Brækhus, Anne | |
dc.contributor.author | Bråthen, Geir | |
dc.contributor.author | de Leeuw, Christiaan A. | |
dc.contributor.author | Desikan, Rahul S. | |
dc.contributor.author | Djurovic, Srdjan | |
dc.contributor.author | Dumitrescu, Logan | |
dc.contributor.author | Fladby, Tormod | |
dc.contributor.author | Hohman, Timothy J. | |
dc.contributor.author | Jónsson, Pálmi V. | |
dc.contributor.author | Kiddle, Steven J | |
dc.contributor.author | Rongve, Arvid | |
dc.contributor.author | Saltvedt, Ingvild | |
dc.contributor.author | Sando, Sigrid Botne | |
dc.contributor.author | Selbæk, Geir | |
dc.contributor.author | Shoai, Maryam | |
dc.contributor.author | Skene, Nathan G. | |
dc.contributor.author | Snædal, Jón G. | |
dc.contributor.author | Stordal, Eystein | |
dc.contributor.author | Ulstein, Ingun | |
dc.contributor.author | Wang, Yunpeng | |
dc.contributor.author | White, Linda Rosemary | |
dc.contributor.author | Hardy, John | |
dc.contributor.author | Hjerling-Leffler, Jens | |
dc.contributor.author | Sullivan, Patrick | |
dc.contributor.author | van der Flier, Wiesje M. | |
dc.contributor.author | Dobson, Richard | |
dc.contributor.author | Davis, Lea K | |
dc.contributor.author | Stefánsson, Hreinn | |
dc.contributor.author | Stefánsson, Kári | |
dc.contributor.author | Pedersen, Nancy L | |
dc.contributor.author | Ripke, Stephan | |
dc.contributor.author | Andreassen, Ole Andreas | |
dc.contributor.author | Posthuma, Danielle | |
dc.date.accessioned | 2020-03-18T08:28:28Z | |
dc.date.available | 2020-03-18T08:28:28Z | |
dc.date.created | 2019-01-15T10:12:43Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Nature Genetics. 2019, 51 (3), 404-413. | nb_NO |
dc.identifier.issn | 1061-4036 | |
dc.identifier.uri | http://hdl.handle.net/11250/2647307 | |
dc.description.abstract | Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, showed strong genetic correlation with AD (rg = 0.81). Meta-analysis identified 29 risk loci, implicating 215 potential causative genes. Associated genes are strongly expressed in immune-related tissues and cell types (spleen, liver, and microglia). Gene-set analyses indicate biological mechanisms involved in lipid-related processes and degradation of amyloid precursor proteins. We show strong genetic correlations with multiple health-related outcomes, and Mendelian randomization results suggest a protective effect of cognitive ability on AD risk. These results are a step forward in identifying the genetic factors that contribute to AD risk and add novel insights into the neurobiology of AD. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Nature Research (part of Springer Nature) | nb_NO |
dc.title | Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 404-413 | nb_NO |
dc.source.volume | 51 | nb_NO |
dc.source.journal | Nature Genetics | nb_NO |
dc.source.issue | 3 | nb_NO |
dc.identifier.doi | 10.1038/s41588-018-0311-9 | |
dc.identifier.cristin | 1656853 | |
dc.description.localcode | © 2019. This is the authors' accepted and refereed manuscript to the chapter. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41588-018-0311-9 | nb_NO |
cristin.unitcode | 1920,16,0,0 | |
cristin.unitcode | 194,65,30,0 | |
cristin.unitcode | 1920,15,0,0 | |
cristin.unitcode | 194,65,35,0 | |
cristin.unitname | Nevroklinikken | |
cristin.unitname | Institutt for nevromedisin og bevegelsesvitenskap | |
cristin.unitname | Medisinsk klinikk | |
cristin.unitname | Institutt for psykisk helse | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |