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dc.contributor.authorJakobsen, Gunnhild
dc.contributor.authorEngstrøm, Morten
dc.contributor.authorThronæs, Morten
dc.contributor.authorLøhre, Erik Torbjørn
dc.contributor.authorKaasa, Stein
dc.contributor.authorFayers, Peter
dc.contributor.authorHjermstad, Marianne Jensen
dc.contributor.authorKlepstad, Pål
dc.date.accessioned2020-02-17T13:37:21Z
dc.date.available2020-02-17T13:37:21Z
dc.date.created2019-11-25T13:01:35Z
dc.date.issued2019
dc.identifier.citationSupportive Care in Cancer. 2019, 1-9.nb_NO
dc.identifier.issn0941-4355
dc.identifier.urihttp://hdl.handle.net/11250/2642034
dc.description.abstractPurpose Although patients with advanced cancer report poor sleep quality, few studies have assessed sleep quality with a combination of subjective and objective measures. We aimed to examine sleep quality in hospitalized patients with advanced cancer by combining patient-reported outcome-measures (PROMs) and polysomnography (PSG) or actigraphy. Methods A one-night prospective observational study of sleep in hospitalized patients with metastatic cancer using WHO step III opioids was conducted. Total sleep time, sleep onset latency, number of awakenings, and wake after sleep onset were assessed by PROMs and actigraphy. Sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI) (range; 0–21), where higher scores indicate worse sleep quality. Results Forty patients were monitored. Median age was 70, median oral morphine equivalent dose was 80 mg/24 h (10–1725), median Karnofsky Performance Score was 50 (20–90), and median time to death from inclusion was 38 days (4–319). Mean PSQI score was 6.5 (SD ± 3.4). PROMs and actigraphy of mean (SD) sleep onset latency were 46 (± 64) and 35 min (± 61), respectively, while mean time awake at night was 37 (± 35) and 40 min (± 21). PROMs and actigraphy differed on number of awakenings (mean 2 (± 1) vs. 24 (± 15), p ˂ 0.001). Bland-Altman plots showed large individual differences between PROMs and actigraphy. PSG was not feasible. Conclusions PROMs and actigraphy documented poor sleep quality, but a lack of agreement across methods. The study demonstrates a need to improve assessment of sleep quality and treatment of sleep disturbance in hospitalized patients with advanced cancer near end of life.nb_NO
dc.language.isoengnb_NO
dc.publisherSpringernb_NO
dc.titleSleep quality in hospitalized patients with advanced cancer: an observational study using self-reports of sleep and actigraphynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber1-9nb_NO
dc.source.journalSupportive Care in Cancernb_NO
dc.identifier.doi10.1007/s00520-019-04998-5
dc.identifier.cristin1751878
dc.description.localcodeThis is a post-peer-review, pre-copyedit version of an article. Locked until 7/8-2020 due to copyright restrictions. The final authenticated version is available online at: https://doi.org/10.1007/s00520-019-04998-5nb_NO
cristin.unitcode1920,12,0,0
cristin.unitcode194,65,15,0
cristin.unitcode194,65,30,0
cristin.unitcode1920,16,0,0
cristin.unitcode194,65,25,0
cristin.unitcode1920,28,0,0
cristin.unitnameKreftklinikken
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameNevroklinikken
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameKlinikk for anestesi og intensivmedisin
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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