dc.contributor.author | Lyngbakken, Magnus | |
dc.contributor.author | Røsjø, Helge | |
dc.contributor.author | Holmen, Oddgeir Lingaas | |
dc.contributor.author | Dalen, Håvard | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Omland, Torbjørn | |
dc.date.accessioned | 2020-02-07T09:45:39Z | |
dc.date.available | 2020-02-07T09:45:39Z | |
dc.date.created | 2019-08-21T14:21:59Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Clinical Chemistry. 2019, 65 (7), 871-881. | nb_NO |
dc.identifier.issn | 0009-9147 | |
dc.identifier.uri | http://hdl.handle.net/11250/2640217 | |
dc.description.abstract | BACKGROUND:Cardiac troponins are associated with car-diovascular risk in the general population, but whethertemporal changes in cardiac troponin I provide indepen-dent prognostic information remains uncertain. Using alarge community-based cohort with follow-up close tothe present day, we aimed to investigate the associationsbetween temporal changes in cardiac troponin and car-diovascular events.METHODS:We measured cardiac troponin I with a high-sensitivity assay (hs-cTnI) in 4805 participants attendingboth the second (HUNT 2, 1995–97) and third wave(HUNT 3, 2006–2008) of the prospective observationalNord-Trøndelag Health (HUNT) Study. Wecon-structed statistical models with both relative and absolutechanges of hs-cTnI from HUNT 2 to HUNT 3. Acomposite end point of cardiovascular death or firstadmission for myocardial infarction or heart failurewas generated.RESULTS:Participants with relative decrease in hs-cTnIwere more frequently younger and female and had lowerblood pressure and body mass index. Participants withrelative increase in hs-cTnI more frequently were olderand male, with higher systolic blood pressure. The ad-justed hazard ratio (HR) for relative increase in hs-cTnIwas 1.68 (95% CI, 1.16–2.42) and the adjusted HR forrelative decrease was 1.19 (95% CI, 0.84–1.68). Abso-lute increases in hs-cTnI exhibited similar prognosticproperties as relative increases in hs-cTnI. The most re-cent measurement of hs-cTnI outperformed the changevariables in discrimination and reclassification models.CONCLUSIONS:Both relative and absolute increases in hs-cTnI are independently associated with cardiovascularrisk. For refinement of risk prediction models, the mostrecent measurement of hs-cTnI should be preferred inclinical practice. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | American Association for Clinical Chemistry | nb_NO |
dc.title | Temporal changes in cardiac troponin i are associated with risk of cardiovascular events in the general population: The Nord-Trøndelag health study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.pagenumber | 871-881 | nb_NO |
dc.source.volume | 65 | nb_NO |
dc.source.journal | Clinical Chemistry | nb_NO |
dc.source.issue | 7 | nb_NO |
dc.identifier.doi | 10.1373/clinchem.2018.301069 | |
dc.identifier.cristin | 1717721 | |
dc.relation.project | Stiftelsen Kristian Gerhard Jebsen: SKGJ-MED-015 | nb_NO |
dc.relation.project | Norges forskningsråd: 299113 | nb_NO |
dc.description.localcode | © 2019. Locked until 4.01.2021 due to copyright restrictions. The final authenticated version is available online at: 10.1373/clinchem.2018.301069 | nb_NO |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,25,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitname | Institutt for samfunnsmedisin og sykepleie | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |