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dc.contributor.authorLyngbakken, Magnus
dc.contributor.authorRøsjø, Helge
dc.contributor.authorHolmen, Oddgeir Lingaas
dc.contributor.authorDalen, Håvard
dc.contributor.authorHveem, Kristian
dc.contributor.authorOmland, Torbjørn
dc.date.accessioned2020-02-07T09:45:39Z
dc.date.available2020-02-07T09:45:39Z
dc.date.created2019-08-21T14:21:59Z
dc.date.issued2019
dc.identifier.citationClinical Chemistry. 2019, 65 (7), 871-881.nb_NO
dc.identifier.issn0009-9147
dc.identifier.urihttp://hdl.handle.net/11250/2640217
dc.description.abstractBACKGROUND:Cardiac troponins are associated with car-diovascular risk in the general population, but whethertemporal changes in cardiac troponin I provide indepen-dent prognostic information remains uncertain. Using alarge community-based cohort with follow-up close tothe present day, we aimed to investigate the associationsbetween temporal changes in cardiac troponin and car-diovascular events.METHODS:We measured cardiac troponin I with a high-sensitivity assay (hs-cTnI) in 4805 participants attendingboth the second (HUNT 2, 1995–97) and third wave(HUNT 3, 2006–2008) of the prospective observationalNord-Trøndelag Health (HUNT) Study. Wecon-structed statistical models with both relative and absolutechanges of hs-cTnI from HUNT 2 to HUNT 3. Acomposite end point of cardiovascular death or firstadmission for myocardial infarction or heart failurewas generated.RESULTS:Participants with relative decrease in hs-cTnIwere more frequently younger and female and had lowerblood pressure and body mass index. Participants withrelative increase in hs-cTnI more frequently were olderand male, with higher systolic blood pressure. The ad-justed hazard ratio (HR) for relative increase in hs-cTnIwas 1.68 (95% CI, 1.16–2.42) and the adjusted HR forrelative decrease was 1.19 (95% CI, 0.84–1.68). Abso-lute increases in hs-cTnI exhibited similar prognosticproperties as relative increases in hs-cTnI. The most re-cent measurement of hs-cTnI outperformed the changevariables in discrimination and reclassification models.CONCLUSIONS:Both relative and absolute increases in hs-cTnI are independently associated with cardiovascularrisk. For refinement of risk prediction models, the mostrecent measurement of hs-cTnI should be preferred inclinical practice.nb_NO
dc.language.isoengnb_NO
dc.publisherAmerican Association for Clinical Chemistrynb_NO
dc.titleTemporal changes in cardiac troponin i are associated with risk of cardiovascular events in the general population: The Nord-Trøndelag health studynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber871-881nb_NO
dc.source.volume65nb_NO
dc.source.journalClinical Chemistrynb_NO
dc.source.issue7nb_NO
dc.identifier.doi10.1373/clinchem.2018.301069
dc.identifier.cristin1717721
dc.relation.projectStiftelsen Kristian Gerhard Jebsen: SKGJ-MED-015nb_NO
dc.relation.projectNorges forskningsråd: 299113nb_NO
dc.description.localcode© 2019. Locked until 4.01.2021 due to copyright restrictions. The final authenticated version is available online at: 10.1373/clinchem.2018.301069nb_NO
cristin.unitcode194,65,20,0
cristin.unitcode194,65,25,0
cristin.unitcode194,65,20,15
cristin.unitnameInstitutt for samfunnsmedisin og sykepleie
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameHelseundersøkelsen i Nord-Trøndelag
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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