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dc.contributor.authorMuller, Lucas Omar
dc.contributor.authorFossan, Fredrik Eikeland
dc.contributor.authorBråten, Anders Tjellaug
dc.contributor.authorJørgensen, Arve
dc.contributor.authorWiseth, Rune
dc.contributor.authorHellevik, Leif Rune
dc.description.abstractModel‐based prediction of fractional flow reserve (FFR) in the context of stable coronary artery disease (CAD) diagnosis requires a number of modelling assumptions. One of these assumptions is the definition of a baseline coronary flow, ie, total coronary flow at rest prior to the administration of drugs needed to perform invasive measurements. Here we explore the impact of several methods available in the literature to estimate and distribute baseline coronary flow on FFR predictions obtained with a reduced‐order model. We consider 63 patients with suspected stable CAD, for a total of 105 invasive FFR measurements. First, we improve a reduced‐order model with respect to previous results and validate its performance versus results obtained with a 3D model. Next, we assess the impact of a wide range of methods to impose and distribute baseline coronary flow on FFR prediction, which proved to have a significant impact on diagnostic performance. However, none of the proposed methods resulted in a significant improvement of prediction error standard deviation. Finally, we show that intrinsic uncertainties related to stenosis geometry and the effect of hyperemic inducing drugs have to be addressed in order to improve FFR prediction accuracy.nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleImpact of baseline coronary flow and its distribution on Fractional Flow Reserve predictionnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.source.journalInternational Journal for Numerical Methods in Biomedical Engineeringnb_NO
dc.relation.projectNotur/NorStore: NN9545Knb_NO
dc.description.localcode© 2019 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons, Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.nb_NO
cristin.unitnameInstitutt for konstruksjonsteknikk
cristin.unitnameKlinikk for hjertemedisin
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameKlinikk for bildediagnostikk

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Navngivelse 4.0 Internasjonal
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