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dc.contributor.authorStøen, Ragnhild
dc.contributor.authorBoswell, Lynn
dc.contributor.authorDe Regnier, Raye-Ann
dc.contributor.authorFjørtoft, Toril Larsson
dc.contributor.authorGaebler-Spira, Deborah
dc.contributor.authorIhlen, Espen Alexander F.
dc.contributor.authorLabori, Cathrine
dc.contributor.authorLoennecken, Marianne
dc.contributor.authorMsall, Michael E.
dc.contributor.authorMoinichen, Unn Inger
dc.contributor.authorPeyton, Colleen
dc.contributor.authorRussow, Annamarie
dc.contributor.authorSchreiber, Michael D.
dc.contributor.authorSilberg, Inger Elisabeth
dc.contributor.authorSongstad, Nils Thomas
dc.contributor.authorVågen, Randi Tynes
dc.contributor.authorØberg, Gunn Kristin
dc.contributor.authorAdde, Lars
dc.date.accessioned2019-11-22T08:42:21Z
dc.date.available2019-11-22T08:42:21Z
dc.date.created2019-10-26T13:10:29Z
dc.date.issued2019
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/11250/2629977
dc.description.abstractBackground: Early prediction of cerebral palsy (CP) using the General Movement Assessment (GMA) during the fidgety movements (FM) period has been recommended as standard of care in high-risk infants. The aim of this study was to determine the accuracy of GMA, alone or in combination with neonatal imaging, in predicting cerebral palsy (CP). Methods: Infants with increased risk of perinatal brain injury were prospectively enrolled from 2009–2014 in this multi-center, observational study. FM were classified by two certified GMA observers blinded to the clinical history. Abnormal GMA was defined as absent or sporadic FM. CP-status was determined by clinicians unaware of GMA results. Results: Of 450 infants enrolled, 405 had scorable video and follow-up data until at least 18–24 months. CP was confirmed in 42 (10.4%) children at mean age 3 years 1 month. Sensitivity, specificity, positive and negative predictive values, and accuracy of absent/sporadic FM for CP were 76.2, 82.4, 33.3, 96.8, and 81.7%, respectively. Only three (8.1%) of 37 infants with sporadic FM developed CP. The highest accuracy (95.3%) was achieved by a combination of absent FM and abnormal neonatal imaging. Conclusion: In infants with a broad range of neonatal risk factors, accuracy of early CP prediction was lower for GMA than previously reported but increased when combined with neonatal imaging. Sporadic FM did not predict CP in this study.nb_NO
dc.language.isoengnb_NO
dc.publisherMDPInb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleThe Predictive Accuracy of the General Movement Assessment for Cerebral Palsy: A Prospective, Observational Study of High-Risk Infants in a Clinical Follow-Up Settingnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.volume8nb_NO
dc.source.journalJournal of Clinical Medicinenb_NO
dc.identifier.doi10.3390/jcm8111790
dc.identifier.cristin1740799
dc.description.localcode© 2019 by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).nb_NO
cristin.unitcode194,65,15,0
cristin.unitcode1920,7,0,0
cristin.unitcode194,65,30,0
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameKlinikk for kliniske servicefunksjoner
cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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