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dc.contributor.authorJakola, Asgeir S
dc.contributor.authorJørgensen, Arve
dc.contributor.authorSelbekk, Tormod
dc.contributor.authorMichler, Ralf-Peter
dc.contributor.authorSolheim, Ole
dc.contributor.authorTorp, Sverre Helge
dc.contributor.authorSagberg, Lisa Millgård
dc.contributor.authorAadahl, Petter
dc.contributor.authorUnsgård, Geirmund
dc.date.accessioned2019-11-04T12:02:33Z
dc.date.available2019-11-04T12:02:33Z
dc.date.created2014-04-07T08:29:52Z
dc.date.issued2014
dc.identifier.citationBMC Medical Imaging. 2014, 14 (11), .nb_NO
dc.identifier.issn1471-2342
dc.identifier.urihttp://hdl.handle.net/11250/2626374
dc.description.abstractBackground Use of ultrasound in brain tumor surgery is common. The difference in attenuation between brain and isotonic saline may cause artifacts that degrade the ultrasound images, potentially affecting resection grades and safety. Our research group has developed an acoustic coupling fluid that attenuates ultrasound energy like the normal brain. We aimed to test in animals if the newly developed acoustic coupling fluid may have harmful effects. Methods Eight rats were included for intraparenchymal injection into the brain, and if no adverse reactions were detected, 6 pigs were to be included with injection of the coupling fluid into the subarachnoid space. Animal behavior, EEG registrations, histopathology and immunohistochemistry were used in assessment. Results In total, 14 animals were included, 8 rats and 6 pigs. We did not detect any clinical adverse effects, seizure activity on EEG or histopathological signs of tissue damage. Conclusion The novel acoustic coupling fluid intended for brain tumor surgery appears safe in rats and pigs under the tested circumstances. Keywords: Brain imaging; Brain tumor; Intraoperative imaging; Ultrasoundnb_NO
dc.language.isoengnb_NO
dc.publisherBMC (part of Springer Nature)nb_NO
dc.relation.urihttp://www.biomedcentral.com/content/pdf/1471-2342-14-11.pdf
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAnimal study assessing safety of an acoustic coupling fluid that holds the potential to avoid surgically induced artifacts in 3D ultrasound guided operationsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber9nb_NO
dc.source.volume14nb_NO
dc.source.journalBMC Medical Imagingnb_NO
dc.source.issue11nb_NO
dc.identifier.doi10.1186/1471-2342-14-11
dc.identifier.cristin1127290
dc.description.localcode© 2014 Jakola et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.nb_NO
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cristin.unitnameInstitutt for nevromedisin og bevegelsesvitenskap
cristin.unitnameNevroklinikken
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameKlinikk for bildediagnostikk
cristin.unitnameInstitutt for klinisk og molekylær medisin
cristin.unitnameLaboratoriemedisinsk klinikk
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