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dc.contributor.authorMørch, Yrr Asbjørg
dc.contributor.authorSandvig, Ioanna
dc.contributor.authorOlsen, Øystein
dc.contributor.authorDonati, Ivan
dc.contributor.authorThuen, Marte
dc.contributor.authorSkjåk-Bræk, Gudmund
dc.contributor.authorHaraldseth, Olav
dc.contributor.authorBrekken, Christian
dc.date.accessioned2019-10-11T06:16:05Z
dc.date.available2019-10-11T06:16:05Z
dc.date.created2011-12-20T09:19:58Z
dc.date.issued2012
dc.identifier.citationContrast Media & Molecular Imaging. 2012, 7 (2), 265-275.nb_NO
dc.identifier.issn1555-4309
dc.identifier.urihttp://hdl.handle.net/11250/2621483
dc.description.abstractThe aim of the present study was to test alginate gels of different compositions as a system for controlled release of manganese ions (Mn2+) for application in manganese‐enhanced MRI (MEMRI), in order to circumvent the challenge of achieving optimal MRI resolution without resorting to high, potentially cytotoxic doses of Mn2+. Elemental analysis and stability studies of Mn‐alginate revealed marked differences in ion binding capacity, rendering Mn/Ba‐alginate gels with high guluronic acid content most stable. The findings were corroborated by corresponding differences in the release rate of Mn2+ from alginate beads in vitro using T1‐weighted MRI. Furthermore, intravitreal (ivit) injection of Mn‐alginate beads yielded significant enhancement of the rat retina and retinal ganglion cell (RGC) axons 24 h post‐injection. Subsequent compartmental modelling and simulation of ivit Mn2+ transport and concentration revealed that application of slow release contrast agents can achieve a significant reduction of ivit Mn2+ concentration compared with bolus injection. This is followed by a concomitant increase in the availability of ivit Mn2+ for uptake by RGC, corresponding to significantly increased time constants. Our results provide proof‐of‐concept for the applicability of Mn‐alginate gels as a system for controlled release of Mn2+ for optimized MEMRI application.nb_NO
dc.language.isoengnb_NO
dc.publisherWileynb_NO
dc.titleMn-alginate gels as a novel system for controlled release of Mn2+ in manganese-enhanced MRInb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.source.pagenumber265-275nb_NO
dc.source.volume7nb_NO
dc.source.journalContrast Media & Molecular Imagingnb_NO
dc.source.issue2nb_NO
dc.identifier.doi10.1002/cmmi.493
dc.identifier.cristin870575
dc.description.localcodeCopyright © 2012 John Wiley & Sons, Ltd. Open Accessnb_NO
cristin.unitcode194,66,15,0
cristin.unitcode194,65,25,0
cristin.unitcode1920,4,0,0
cristin.unitnameInstitutt for bioteknologi og matvitenskap
cristin.unitnameInstitutt for sirkulasjon og bildediagnostikk
cristin.unitnameKlinikk for bildediagnostikk
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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