Blar i St. Olavs hospital på tittel

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    • Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts 

      Wang, Ying; Lopera, Esteban; Namba, Shinichi; Kerminen, Sini; Tsuo, Kristin; Läll, Kristi; Kanai, Masahiro; Zhou, Wei; Wu, Kuan-Han; Favé, Marie-Julie; Bhatta, Laxmi; Awadalla, Philip; Brumpton, Ben Michael; Deelen, Patrick; Hveem, Kristian; Faro, Valeria Lo; Mägi, Reedik; Murakami, Yoshinori; Sanna, Serena; Smoller, Jordan W.; Uzunovic, Jasmina; Wolford, Brooke N.; GBMI, .; Willer, Cristen; Gamazon, Eric R.; Cox, Nancy J.; Surakka, Ida; Okada, Yukinori; Martin, Alicia R.; Hirbo, Jibril B. (Peer reviewed; Journal article, 2023)
      Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases. We here utilized data ...

    • The Global Campaign turns 18: a brief review of its activities and achievements 

      Steiner, Timothy J.; Birbeck, Gretchen L.; Jensen, Rigmor H.; Martelletti, Paolo; Stovner, Lars Jacob; Uluduz, Derya; Leonardi, Matilde; Olesen, Jes; Katsarava, Zaza (Peer reviewed; Journal article, 2022)

    • Global longitudinal strain is a more reproducible measure of left ventricular function than ejection fraction regardless of echocardiographic training 

      Karlsen, Sigve; Dahlslett, Thomas; Grenne, Bjørnar; Sjøli, Benthe; Smiseth, Otto A.; Edvardsen, Thor; Brunvand, Harald (Peer reviewed; Journal article, 2019)
      Background: Left ventricular ejection fraction (LVEF) is an established method for evaluation of left ventricular (LV)systolic function. Global longitudinal strain (GLS) by speckle tracking echocardiography seems to be an ...

    • Global Metabolomics Discovers Two Novel Biomarkers in Pyridoxine-Dependent Epilepsy Caused by ALDH7A1 Deficiency 

      Böhm, Hans-Otto; Yazdani, Mazyar; Mørk Sandås, Elise; Østeby Vassli, Anja; Kristensen, Erle; Rootwelt, Helge; Skogvold, Hanne Bendiksen; Brodtkorb, Eylert; Elgstøen, Katja B. Prestø (Peer reviewed; Journal article, 2022)
      Pyridoxine-dependent epilepsy (PDE) is a rare autosomal recessive developmental and epileptic encephalopathy caused by pathogenic variants in the ALDH7A1 gene (PDE-ALDH7A1), which mainly has its onset in neonates and ...

    • The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates 

      Stovner, Lars Jacob; Hagen, Knut; Linde, Mattias; Steiner, Timothy J. (Peer reviewed; Journal article, 2022)
      Background According to the Global Burden of Disease (GBD) study, headache disorders are among the most prevalent and disabling conditions worldwide. GBD builds on epidemiological studies (published and unpublished) ...

    • Global variation in anastomosis and end colostomy formation following left-sided colorectal resection 

      Glasbey, James C.; Adisa, Adewale O.; Costas-Chavarri, Ainhoa; Qureshi, Ahmad U.; Allen-Ingabire, Jean C.; Salem, Hosni Khairy; Lossius, William J; Havemann, Ingemar; Thorsen, Kenneth; Narvestad, Jon; Søreide, Kjetil; Wold, Trude Beate; Nymo, Linn Såve; Veen, Torhild; Kanani, Arezo; Styles, Kristian; Herikstad, Ragnar; Larsen, Johannes Wiik; Søreide, Jon Arne; Jensen, Elisabeth; Gran, Mads; Aahlin, Eirik Kjus; Gaarder, Christine; Monrad-Hansen, Peter Wiel; Næss, Pål Aksel; Lauzikas, Giedrius; Wiborg, Joachim; Holte, Silje Stensholt; Augestad, Knut Magne; Singh, Banipal Gurpreet; Monteleone, Michela Maria Angela; Moe, Thomas Tetens; Schultz, Johannes Kurt; Bliksøen, Marte; Kojo, Anyomih Theophilus Teddy; Tabiri, Stephen; Nepogodiev, Dmitri; Lilford, Richard J.; Harrison, Ewen M.; Pinkney, Thomas; Smart, Neil; Bhangu, Aneel; Ademuyiwa, Adesoji; Aguilera, Maria Lorena; Altamini, Afnan; Alexander, Philip; Al-Saqqa, Sara W.; Borda-Luque, Giuliano; Cornick, Jen; Drake, Thomas M. (Peer reviewed; Journal article, 2019)
      Background: End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation ...

    • Glucagon-Like Peptide 1 Receptor Agonists and Risk of Diabetic Retinopathy Complications: Cohort Study in Nationwide Registers From Two Countries 

      Ueda, Peter; Pasternak, Björn; Eliasson, Björn; Svensson, Ann-Marie; Franzén, Stefan; Gudbjörnsdóttir, Soffia; Hveem, Kristian; Jonasson, Christian; Melbye, Mads; Svanström, Henrik (Journal article; Peer reviewed, 2019)
      Post hoc analyses of the Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes (SUSTAIN-6) showed an increased risk of diabetic retinopathy complications associated ...

    • Glucoregulatory Properties of a Protein Hydrolysate from Atlantic Salmon (Salmo salar): Preliminary Characterization and Evaluation of DPP-IV Inhibition and Direct Glucose Uptake In Vitro 

      Bjerknes, Christian; Wubshet, Sileshi Gizachew; Rønning, Sissel Beate; Afseth, Nils Kristian; Crawford, Currie; Framroze, Bomi; Hermansen, Erland (Journal article; Peer reviewed, 2024)
      Metabolic disorders are increasingly prevalent conditions that manifest pathophysiologically along a continuum. Among reported metabolic risk factors, elevated fasting serum glucose (FSG) levels have shown the most substantial ...

    • Group Metacognitive Therapy for Generalized Anxiety Disorder: A Pilot Feasibility Trial 

      Haseth, Svein; Solem, Stian; Baardsen, Grethe Sørø; Bjørnstad, Eirin; Grøtte, Torun; Fisher, Peter Leonard (Journal article; Peer reviewed, 2019)
      Background: Individual metacognitive therapy (MCT) for generalized anxiety disorder (GAD) is well established, but only one study has investigated the effectiveness of Group MCT (g-MCT) for GAD. The aim of the current study ...

    • Group-based multimodal physical therapy in women with chronic pelvic pain: A randomized controlled trial 

      Nygaard, Ane Sigrid; Rydningen, Mona Birgitte; Stedenfeldt, Mona; Wojniusz, Slawomir; Larsen, Marthe; Lindsetmo, Rolv-Ole; Haugstad, Gro Killi; Øian, Pål (Journal article; Peer reviewed, 2020)
      Introduction - Chronic pelvic pain in women is a complex condition, and physical therapy is recommended as part of a broader treatment approach. The objective of this study was to compare structured group‐based multimodal ...

    • Growth during infancy and early childhood in children with cerebral palsy: a population-based study 

      Strand, Kristin Melheim; Dahlseng, Magnus Odin; Lydersen, Stian; Rø, Torstein Baade; Finbråten, Ane-Kristine; Jahnsen, Reidun; Andersen, Guro Lillemoen; Vik, Torstein (Peer reviewed; Journal article, 2016)
      Aim To describe growth in infancy and early childhood in children with cerebral palsy (CP). Method One hundred and four children with CP born at minimum 36 weeks' gestation in 2002 to 2010 were included. Prospectively ...

    • GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia 

      Marwarha, Gurdeep; Røsand, Øystein; Slagsvold, Katrine Hordnes; Høydal, Morten (Peer reviewed; Journal article, 2022)
      Apoptotic cell death is a deleterious consequence of hypoxia-induced cellular stress. The master hypoxamiR, microRNA-210 (miR-210), is considered the primary driver of the cellular response to hypoxia stress. We have ...

    • Guideline-Recommended Time Less Than 90 Minutes From ECG to Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Is Associated with Major Survival Benefits, Especially in Octogenarians: A Contemporary Report in 11 226 Patients from NORIC 

      Larsen, Alf Inge; Løland, Kjetil Halvorsen; Hovland, Siren; Bleie, Øyvind; Eek, Christian; Fossum, Eigil; Trovik, Thor; Juliebø, Vibeke; Hegbom, Knut; Moer, Rasmus; Larsen, Tomas; Uchto, Michael; Rotevatn, Svein (Peer reviewed; Journal article, 2022)
      Background - Using contemporary data from NORIC (Norwegian Registry of Invasive Cardiology) we investigated the predictive value of patient age and time from ECG diagnosis to sheath insertion (ECG‐2‐sheath) in primary ...

    • GWAS for autoimmune Addison's disease identifies multiple risk loci and highlights AIRE in disease susceptibility 

      Eriksson, Daniel; Røyrvik, Ellen Christine; Aranda-Guillen, Maribel; Berger, Amund Holte; Landegren, Nils; Artaza, Haydee; Hallgren, Åsa; Grytaas, Marianne; Strøm, Sara; Bratland, Eirik; Botusan, Ileana; Oftedal, Bergithe Eikeland; Breivik, Lars Ertesvåg; Vaudel, Marc; Helgeland, Øyvind; Falorni, Alberto; Jørgensen, Anders Palmstrøm; Hulting, Anna-Lena; Svartberg, Johan; Ekwall, Olov; Fougner, Kristian J; Wahlberg, Jeanette; Nedrebø, Bjørn Gunnar; Dahlqvist, Per; Study group, Norwegian Addison Registry; Study Group, Swedish Addison Registry; Knappskog, Per Morten; Wolff, Anette Susanne Bøe; Bensing, Sophie; Johansson, Stefan; Kämpe, Olof; Husebye, Eystein Sverre (Peer reviewed; Journal article, 2021)
      Autoimmune Addison’s disease (AAD) is characterized by the autoimmune destruction of the adrenal cortex. Low prevalence and complex inheritance have long hindered successful genetic studies. We here report the first ...

    • GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors 

      Docherty, Anna R.; Mullins, Niamh; Ashley-Koch, Allison E.; Qin, Xuejun; Coleman, Jonathan R.I.; Shabalin, Andrey; Kang, JooEun; Murnyak, Balasz; Wendt, Frank; Adams, Mark; Campos, Adrian I.; DiBlasi, Emily; Fullerton, Janice M.; Kranzler, Henry R.; Bakian, Amanda V.; Monson, Eric T.; Rentería, Miguel E.; Walss-Bass, Consuelo; Andreassen, Ole; Behera, Chittaranjan; Bulik, Cynthia M.; Edenberg, Howard J.; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Alfredsson, Lars; Appadurai, Vivek; Artigas, María Soler; Djurovic, Srdjan; Foo, Jerome C.; Forstner, Andreas J.; Frye, Mark; Gatt, Justine; Melle, Ingrid; Mitchell, Philip B.; Molina, Esther; Morken, Gunnar; Smeland, Olav Bjerkehagen; Smoller, Jordan W.; Sonuga-Barke, Edmund J.S.; Trzaskowski, Maciej; Tsuang, Ming T.; Turecki, Gustavo; Vilar-Ribó, Laura; Vincent, John B.; Völzke, Henry; Walters, James T.R.; Weickert, Cynthia Shannon; Weickert, Thomas W.; Weissman, Myrna M. (Peer reviewed; Journal article, 2023)
      Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for ...

    • GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer 

      Zhou, Wei; Brumpton, Ben Michael; Kabil, Omer; Gudmundsson, Julius; Thorleifsson, Gudmar; Weinstock, Joshua; Zawistowski, Matthew; Nielsen, Jonas Bille; Chaker, Layal; Medici, Marco; Teumer, Alexander; Naitza, Silvia; Sanna, Serena; Schultheiss, Ulla T.; Cappola, Anne R.; Karjalainen, Juha; Kurki, Mitja I.; Oneka, Morgan; Taylor, Peter; Fritsche, Lars; Graham, Sarah E.; Wolford, Brooke N.; Overton, William; Rasheed, Humaira; Bordal, Eirin Haug; Gabrielsen, Maiken Elvestad; Skogholt, Anne Heidi; Surakka, Ida; Davey Smith, George; Pandit, Anita; Roychowdhury, Tanmoy; Hornsby, Whitney; Jonasson, Jon G.; Senter, Leigha; Liyanarachchi, Sandya; Ringel, Matthew D.; Xu, Li; Kiemeney, Lambertus A.; He, Huiling; Netea-Maier, Romana; Mayordomo, Jose; Plantinga, Theo S.; Hrafnkelsson, Jon; Hjartarson, Hannes; Sturgis, Erich M.; Palotie, Aarno; Daly, Mark J.; Citterio, Cintia E.; Arvan, Peter; Brummett, Chad M.; Boehnke, Michael; de la Chapelle, Albert; Stefansson, Kari; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav (Peer reviewed; Journal article, 2020)
      Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. To better understand the genetic contribution to TSH levels, we conduct a GWAS meta-analysis at 22.4 million genetic markers in up to ...

    • H2G-Net: A multi-resolution refinement approach for segmentation of breast cancer region in gigapixel histopathological images 

      Pedersen, André; Smistad, Erik; Rise, Tor Vikan; Dale, Vibeke Grotnes; Pettersen, Henrik P Sahlin; Nordmo, Tor-Arne Schmidt; Bouget, David Nicolas Jean-Mar; Reinertsen, Ingerid; Valla, Marit (Journal article; Peer reviewed, 2022)
      Over the past decades, histopathological cancer diagnostics has become more complex, and the increasing number of biopsies is a challenge for most pathology laboratories. Thus, development of automatic methods for evaluation ...

    • Habilitering for voksne i spesialisthelsetjenesten: Utvikling og utprøving av brukerundersøkelse 

      Søndenaa, Erik; Sauarlia, Stein Ketil; Hukkelås, Britt; Jullumstrø, Sidsel (Peer reviewed; Journal article, 2016)
      Habilitation specialist service for adults in Sør-Trøndelag has developed and implemented a model for user perceptions over the last five years. As users of the service consist of diverted parts, the work has aimed at ...

    • Hallmarks of Criticality in Neuronal Networks Depend on Cell Type and the Temporal Resolution of Neuronal Avalanches 

      Heiney, Kristine; Valderhaug, Vibeke Devold; Huse Ramstad, Ola; Sandvig, Ioanna; Sandvig, Axel; Nichele, Stefano (Peer reviewed; Journal article, 2021)
      The human brain has a remarkable capacity for computation, and it has been theorized that this capacity arises from the brain self-organizing into the critical state, a dynamical state poised between ordered and dis- ordered ...

    • Hand surgery in Norway 

      Reigstad, Ole; Lied, Line (Peer reviewed; Journal article, 2020)