• Diffusion Tensor and Kurtosis Imaging Findings the First Year Following Mild Traumatic Brain Injury 

      Stenberg, Jonas; Skandsen, Toril; Moen, Kent Gøran; Vik, Anne; Eikenes, Live; Håberg, Asta (Journal article; Peer reviewed, 2022)
    • Diffusion tensor imaging in middle-aged headache sufferers in the general population: A cross-sectional population-based imaging study in the Nord-Trøndelag health study (HUNT-MRI) 

      Husøy, Andreas Kattem; Eikenes, Live; Håberg, Asta; Hagen, Knut; Stovner, Lars Jacob (Journal article; Peer reviewed, 2019)
      Background Several studies have investigated white matter with diffusion tensor imaging (DTI) in those suffering from headache, but so far only in clinic based samples and with conflicting results. Methods In the present ...
    • Digital cognitive behaviour therapy for insomnia (dCBT-I): Chronotype moderation on intervention outcomes 

      Faaland, Patrick; Vedaa, Øystein; Langsrud, Knut; Sivertsen, Børge; Lydersen, Stian; Vestergaard, Cecilie Lund; Kjørstad, Kaia; Vethe, Daniel; Ritterband, Lee M.; Harvey, Allison G.; Stiles, Tore C; Scott, Janine Linda; Kallestad, Håvard (Peer reviewed; Journal article, 2022)
      Using data from 1721 participants in a community-based randomized control trial of digital cognitive behavioural therapy for insomnia compared with patient education, we employed linear mixed modelling analyses to examine ...
    • Digital cognitive behaviour therapy for insomnia in individuals with self-reported insomnia and chronic fatigue: A secondary analysis of a large scale randomized controlled trial 

      Ramfjord, Lina Stålesen; Faaland, Patrick Michael Palmelund; Scott, Janine Linda; Saksvik, Simen Berg; Lydersen, Stian; Vedaa, Øystein; Kahn, Nikolaj; Langsrud, Knut; Stiles, Tore Charles; Ritterband, Lee M.; Harvey, Allison G.; Sivertsen, Børge; Kallestad, Håvard (Peer reviewed; Journal article, 2023)
      Insomnia is associated with fatigue, but it is unclear whether response to cognitive behaviour therapy for insomnia is altered in individuals with co-occurring symptoms of insomnia and chronic fatigue. This is a secondary ...
    • Digital cognitive-behavioural therapy for insomnia compared with digital patient education about insomnia in individuals referred to secondary mental health services in Norway: Protocol for a multicentre randomised controlled trial 

      Kallestad, Håvard; Saksvik, Simen Berg; Vedaa, Øystein; Langsrud, Knut; Morken, Gunnar; Lydersen, Stian; Simpson, Melanie Rae; Dørheim, Signe Karen; Holmøy, Bjørn; Germans Selvik, Sara; Hagen, Kristen; Stiles, Tore C; Harvey, Allison G.; Ritterband, Lee M.; Sivertsen, Børge; Scott, Janine Linda (Peer reviewed; Journal article, 2021)
      Introduction Insomnia is highly prevalent in outpatients receiving treatment for mental disorders. Cognitive–behavioural therapy for insomnia (CBT-I) is a recommended first-line intervention. However, access is limited and ...
    • A digital Norwegian version of the client satisfaction questionnaire 8: factor validity and internal reliability in outpatient mental health care 

      Pedersen, Henrik; Havnen, Audun; Brattmyr, Lars Martin; Attkisson, C. Clifford; Lara Cabrera, Mariela Loreto (Peer reviewed; Journal article, 2022)
      Background Validated measures of patient-reported experiences are essential for assessing and improving the quality of mental health services and interventions. In Norwegian mental healthcare settings, the Client Satisfaction ...
    • Direct and indirect effects of socioeconomic status on sepsis risk and mortality: a mediation analysis of the HUNT Study 

      Stensrud, Vilde; Gustad, Lise Tuset; Damås, Jan Kristian; Solligård, Erik; Krokstad, Steinar; Nilsen, Tom Ivar Lund (Peer reviewed; Journal article, 2023)
      Background Socioeconomic status (SES) may influence risk of sepsis and sepsis-related mortality, but to what extent lifestyle and health-related factors mediate this effect is not known. Methods The study included 65 227 ...
    • Direction- and Angle-Assisted Buttonhole Cannulation of Arteriovenous Fistula in Hemodialysis Patients: A Multicenter Randomized Controlled Trial 

      Rønning, Marit I.; Benschop, Willem Pieter; Øvrehus, Marius Altern; Hultstrøm, Maria; Hallan, Stein (Peer reviewed; Journal article, 2022)
      Rationale & objective: Arteriovenous fistula cannulation with the buttonhole technique is often preferred by patients but has been associated with an increased infection risk. Guidelines disagree on whether it should be ...
    • Discontinuation rate of sulfasalazine, leflunomide and methotrexate due to adverse events in a real-life setting (NOR-DMARD) 

      Pawel, Mielnik; Sexton, Joseph; Fagerli, Karen Minde; Bakland, Gunnstein; Hu, Yi; Kristianslund, Eirik; Hoff, Mari; Wierød, Ada; Kvien, Tore Kristian Aaserud (Peer reviewed; Journal article, 2023)
      Objectives MTX, LEF and SSZ are conventional synthetic DMARDs (csDMARDs) with a well-established role in the treatment of RA. We aimed to estimate and compare the relative risks for adverse events (AEs) and the ...
    • Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals 

      Stanzick, Kira J.; Li, Yong; Schlosser, Pascal; Gorski, Mathias; Wuttke, Matthias; Thomas, Laurent F.; Rasheed, Humaira; Rowan, Bryce X.; Graham, Sarah E.; Vanderweff, Brett R.; Patil, Snehal B.; Robinson-Cohen, Cassiane; Gaziano, John M.; O’Donnell, Christopher J.; Willer, Cristen J.; Hallan, Stein; Åsvold, Bjørn Olav; Gessner, Andre; Hung, Adriana M.; Pattaro, Cristian; Köttgen, Anna; Stark, Klaus; Heid, Iris M.; Winkler, Thomas W. (Journal article; Peer reviewed, 2021)
      Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing variants and genes is challenging. By GWAS meta-analysis for ...
    • Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants 

      Aragam, Krishna G.; Jiang, Tao; Goel, Anuj; Kanoni, Stavroula; Wolford, Brooke N.; Atri, Deepak S.; Weeks, Elle M.; Wang, Minxian; Hindy, George; Zhou, Wei; Grace, Christopher; Roselli, Carolina; Marston, Nicholas A.; Kamanu, Frederick K.; Surakka, Ida; Venegas, Loreto Muñoz; Sherliker, Paul; Koyama, Satoshi; Ishigaki, Kazuyoshi; Åsvold, Bjørn Olav; Brown, Michael R.; Brumpton, Ben Michael; de Vries, Paul S.; Giannakopoulou, Olga; Giardoglou, Panagiota; Gudbjartsson, Daniel F.; Güldener, Ulrich; Haider, Syed M. Ijlal; Helgadottir, Anna; Ibrahim, Maysson; Kastrati, Adnan; Kessler, Thorsten; Kyriakou, Theodosios; Konopka, Tomasz; Li, Ling; Ma, Lijiang; Meitinger, Thomas; Mucha, Sören; Munz, Matthias; Murgia, Federico; Nielsen, Jonas Bille; Nöthen, Markus M.; Pang, Shichao; Reinberger, Tobias; Schnitzler, Gavin; Smedley, Damian; Thorleifsson, Gudmar; von Scheidt, Moritz; Ulirsch, Jacob C.; Danesh, John; Arnar, David O.; Burtt, Noël P.; Costanzo, Maria C.; Flannick, Jason; Ito, Kaoru; Jang, Dong-Keun; Kamatani, Yoichiro; Khera, Amit V.; Komuro, Issei; Kullo, Iftikhar J.; Lotta, Luca A.; Nelson, Christopher P.; Roberts, Robert; Thorgeirsson, Gudmundur; Thorsteinsdottir, Unnur; Webb, Thomas R.; Baras, Aris; Björkegren, Johan L. M.; Boerwinkle, Eric; Dedoussis, George; Holm, Hilma; Hveem, Kristian; Melander, Olle; Morrison, Alanna C.; Orho-Melander, Marju; Rallidis, Loukianos S.; Ruusalepp, Arno; Sabatine, Marc S.; Stefansson, Kari; Zalloua, Pierre; Ellinor, Patrick T.; Farrall, Martin; Danesh, John; Ruff, Christian T.; Finucane, Hilary K.; Hopewell, Jemma C.; Clarke, Robert; Gupta, Rajat M.; Erdmann, Jeanette; Samani, Nilesh J.; Schunkert, Heribert; Watkins, Hugh; Willer, Cristen J.; Deloukas, Panos; Kathiresan, Sekar; Butterworth, Adam S.; de Vries, Paul S.; von Scheidt, Moritz (Peer reviewed; Journal article, 2022)
      The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD) ...
    • Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model 

      Andreassen, Maren Marie Sjaastad; Rodriguez-Soto, Ana; Conlin, CC; Vidić, I; Seibert, TM; Wallace, AM; Zare, S; Kuperman, J; Abudu, B; Ahn, GS; Hahn, M; Jerome, Neil Peter; Østlie, Agnes; Bathen, Tone Frost; Ojeda-Fournier, H; Goa, Pål Erik; Rakow-Penner, Rebecca; Dale, AM (Peer reviewed; Journal article, 2020)
      Purpose: Diffusion-weighted MRI (DW-MRI) is a contrast-free modality that has demonstrated ability to discriminate between predefined benign and malignant breast lesions. However, how well DW-MRI discriminates cancer from ...
    • Disease-associated reference intervals for twenty laboratory tests in patients with rheumatoid arthritis, Crohn's disease or ulcerative colitis 

      Mikkelsen, Gustav; Lillebo, Børge; Faxvaag, Arild (Peer reviewed; Journal article, 2021)
      Background Population based reference intervals are fundamental for interpreting results for quantitative laboratory tests. In patients with a specific chronic disorder, however, results of various tests may regularly be ...
    • Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors 

      Mullins, Niamh; Kang, JooEun; Campos, Adrian I.; Coleman, Jonathan R.I.; Edwards, Alexis C.; Galfalvy, Hanga; Levey, Daniel F.; Lori, Adriana; Shabalin, Andrey A; Andreassen, Ole; Melle, Ingrid; Morken, Gunnar; Starnawska, Anna; Su, Mei-Hsin; Watson, Hunna J; Adams, Mark; Awasthi, Swapnil; Gandal, Michael; Hafferty, Jonathan; Hishimoto, Akitoyo; Kim, Minsoo; Okazaki, Satoshi; Otsuka, Ikuo; Ware, Erin B.; Stephan, Ripke; Bergen, Andrew W.; Berrettini, Wade H.; Bohus, Martin; Brandt, Harry; Chang, Xiao; Chen, Wei J; Chen, Hsi-Chung; Crawford, Steven; Crow, Scott; DiBlasi, Emily; Duriez, Philibert; Fichter, Manfred M; Fernández-Aranda, Fernando; Gallinger, Steven; Glatt, Stephen J.; Gorwood, Philip; Guo, Yiran; Hakonarson, Hakon; Halmi, Katherine A; Hwu, Hai-Gwo; Jain, Sonia; Jamain, Stephane; Jimenez-Murcia, Susana; Johnson, Craig; Djurovic, Srdjan (Peer reviewed; Journal article, 2022)
      Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic ...
    • Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases. 

      de Jesus, Adriana Almeida; Hou, Yangfeng; Brooks, Stephen; Malle, Louise; Biancotto, Angelique; Huang, Yan; Calvo, Katherine R.; Marrero, Bernadette; Moir, Susan; Oler, Andrew J.; Deng, Zuoming; Sanchez, Gina A. Montealegre; Ahmed, Amina; Allenspach, Eric; Srabshahi, Bita; Behrens, Edward M.; Benseler, Susanne; Berzrodnik, Liliana; Bout-Tabaku, Sharon; Brescia, AnneMarie; Brown, Diane; Burnham, Jon M.; Caldirola, Maria Soledad; Carrasco, Ruy; Chan, Alice; Cimaz, Rolando; Dancey, Paul; Dare, Jason; DeGuzman, Marietta; Dimitriades, Victoria; Ferguson, Ian; Ferguson, Polly J.; Finn, Laura; Gattorno, Marco; Grom, Alexei; Hanson, Eric P.; Hashkes, Philip; Hedrich, Christian M.; Herzog, Ronit; Horneff, Gerd; Jerath, Rita; Kessler, Elizabeth; Kim, Hanna; Kingsbury, Daniel J.; Laxer, Ronald M; Lee, Pui Y.; Lee-Kirsch, Min Ae; Lewandowski, Laura; Li, Suzanne; Lilleby, Vibke; Mammadova, Vafa; Moorthy, Lakshmi N.; Nasrullayeva, Gulnara M.; O'Neill, Kathleen; Onel, Karen; Ozen, Seza; Pan, Nancy; Pillet, Pascal; Piotto, Daniela G. P.; Punaro, Marilynn G.; Reiff, Andreas; Reinhardt, Adam L.; Rider, Lisa G.; Rivas-Chacon, Rafael; Ronis, Tova; Rosen-Wolff, Angela; Roth, Johannes; Ruth, Natasha Mckerran; Rygg, Marite; Schmeling, Heinrike; Schulert, Grant; Scott, Christiaan; Seminario, Gisella; Schulman, Andrew; Sivaraman, Vidya; Son, Mary Beth; Stepanovskiy, Yuriy; Stringer, Elizabeth; Taber, Sara; Terreri, Maria Teresa; Tifft, Cynthia J; Torgerson, Troy R.; Tosi, Laura; Royen-Kerkhof, Annet Van; Muskardin, Theresa Wampler; Canna, Scott W.; Goldbach-Mansky, Raphaela (Peer reviewed; Journal article, 2020)
      BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available ...
    • Distinguishing sleep from wake with a radar sensor: A contact-free real-time sleep monitor 

      Heglum, Hanne Siri Amdahl; Kallestad, Håvard; Vethe, Daniel; Langsrud, Knut; Sand, Trond; Engstrøm, Morten (Journal article; Peer reviewed, 2021)
      This work aimed to evaluate whether a radar sensor can distinguish sleep from wakefulness in real time. The sensor detects body movements without direct physical contact with the subject and can be embedded in the roof of ...
    • Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction 

      Mundal, Siv Boon; Rakner, Johanne Johnsen; Silva, Gabriela; Gierman, Lobke; Austdal, Marie; Basnet, Purusotam; Elschot, Mattijs; Bakke, Siril Skaret; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Moses, Eric; Acharya, Ganesh; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2022)
      Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are ...
    • DNA glycosylase Neil2 contributes to genomic responses in the spleen during clinical prion disease 

      Scheffler, Katja; Jalland, Clara Maria Osnes; Benestad, Sylvie L.; Moldal, Torfinn; Ersdal, Cecilie; Gunnes, Gjermund; Suganthan, Rajikala; Bjørås, Magnar; Tranulis, Michael A. (Peer reviewed; Journal article, 2020)
      The DNA glycosylase Neil2 is a member of the base excision repair (BER) family of enzymes, which are important for repair of oxidative DNA damage. Specifically, Neil2 participates in repair of oxidized bases in single-stranded ...
    • DNA Methylation Adds Prognostic Value to Minimal Residual Disease Status in Pediatric T-Cell Acute Lymphoblastic Leukemia 

      Borssén, Magnus; Haider, Zahra; Landfors, Mattias; Norén-Nyström, Ulrika; Schmiegelow, Kjeld; Åsberg, Ann Elisabeth; Kanerva, Jukka; Madsen, Hans O.; Marquart, Hanne; Heyman, Mats; Hultdin, Magnus; Roos, Göran; Forestier, Erik; Degerman, Sofie (Peer reviewed; Journal article, 2016)
      Background. Despite increased knowledge about genetic aberrations in pediatric T-cell acute lymphoblastic leukemia (T-ALL), no clinically feasible treatment-stratifying marker exists at diagnosis. Instead patients are ...
    • DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival 

      Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten Beck; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)
      Background Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ...