Blar i St. Olavs hospital på tittel

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    • Carfilzomib and dexamethasone maintenance following salvage ASCT in multiple myeloma: A randomised phase 2 trial by the Nordic Myeloma Study Group 

      Gregersen, Henrik; Peceliunas, Valdas; Remes, Kari; Schjesvold, Fredrik Hellem; Abildgaard, Niels; Nahi, Hareth; Andersen, Niels Frost; Vangsted, Annette Juul; Klausen, Tobias Wirenfeldt; Helleberg, Carsten; Carlson, Kristina; Frølund, Ulf Christian; Axelsson, Per; Stromberg, Olga; Blimark, Cecilie Hveding; Crafoord, Jacob; Tsykunova, Galina; Eshoj, Henrik Rode; Waage, Anders; Hansson, Markus; Gulbrandsen, Nina (Peer reviewed; Journal article, 2021)
      Objective We investigated the efficacy and safety of carfilzomib-containing induction before salvage high-dose melphalan with autologous stem-cell transplantation (salvage ASCT) and maintenance with carfilzomib and ...

    • Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study. 

      Steyerberg, Ewout W; Wiegers, E; Sewalt, C.; Buki, Andras; Citerio, Giuseppe; De Keyser, Veronique; Ercole, Ari; Kunzmann, K.R.; Lanyon, Linda; Lecky, Fiona; Lingsma, Hester F; Manley, Geoffrey T; Nelson, D; Peul, Wilco; Stocchetti, Nino; von Steinbüchel, Nicole; Vande Vyvere, Thijs; Verheyden, Jan; Wilson, Lindsay; Maas, AIR; Menon, David; Vik, Anne; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røise, Olav; Skandsen, Toril; Røe, Cecilie (Peer reviewed; Journal article, 2019)
      BACKGROUND: The burden of traumatic brain injury (TBI) poses a large public health and societal problem, but the characteristics of patients and their care pathways in Europe are poorly understood. We aimed to characterise ...

    • Catastrophic expenditure and impoverishment after caesarean section in Sierra Leone: An evaluation of the free health care initiative 

      van Duinen, Aalke Johan; Westendorp, Josien; Ashley, Thomas; Hagander, Lars; Holmer, Hampus; Koroma, Alimamy P.; Leather, Andy J.M.; Shrime, Mark G.; Wibe, Arne; Bolkan, Håkon Angell (Peer reviewed; Journal article, 2021)
      Background Utilizing surgical services, including caesarean sections, can result in catastrophic expenditure and impoverishment. In 2010, Sierra Leone introduced the Free Health Care Initiative (FHCI), a national financial ...

    • Causes of inferior relative survival after testicular germ cell tumor diagnosed 1953–2015: A population-based prospective cohort study 

      Kvammen, Øivind; Myklebust, Tor Åge; Solberg, Arne; Møller, Bjørn; Klepp, Olbjørn; Fosså, Sophie Dorothea; Tandstad, Torgrim (Journal article; Peer reviewed, 2019)
      Background Testicular germ cell tumor (TGCT) patients and survivors have excess mortality compared to the general male population, but relative survival (RS) has been scarcely studied. We investigated causes of excess ...

    • CCND1 amplification in breast cancer -associations with proliferation, histopathological grade, molecular subtype and prognosis 

      Valla, Marit; Klæstad, Elise; Ytterhus, Borgny; Bofin, Anna M. (Peer reviewed; Journal article, 2022)
      CCND1 is located on 11q13. Increased CCND1 copy number (CN) in breast cancer (BC) is associated with high histopathological grade, high proliferation, and Luminal B subtype. In this study of CCND1 in primary BCs and ...

    • Cementless unicompartmental knee arthroplasty results in higher pain levels compared to the cemented technique: a prospective register study 

      Gifstad, Tone; Nordskar, Jørgen Jebens; Egeberg, Tarjei; Wik, Tina Strømdal; Winther, Siri Bjørgen (Peer reviewed; Journal article, 2021)
      Purpose In recent years, the preferred fxation method for unicompartmental knee arthroplasty (UKA) has changed from cemented to cementless. The aim of this study was to compare patient-reported outcome measures (PROMs) ...

    • CENIT (Impact of Cardiac Exercise Training on Lipid Content in Coronary Atheromatous Plaques Evaluated by Near-Infrared Spectroscopy): A Randomized Trial 

      Vesterbekkmo, Elisabeth Kleivhaug; Madssen, Erik; Aksetøy, Inger-Lise Aamot; Follestad, Turid; Nilsen, Hans-Olav; Hegbom, Knut; Wisløff, Ulrik; Wiseth, Rune (Peer reviewed; Journal article, 2022)
      Background The effect of physical exercise on lipid content of coronary artery plaques is unknown. With near infrared spectroscopy we measured the effect of high intensity interval training (HIIT) on lipid content in ...

    • Central Pathology Review in SENTIX, A Prospective Observational International Study on Sentinel Lymph Node Biopsy in Patients with Early-Stage Cervical Cancer (ENGOT-CX2) 

      Nemejcova, Kristyna; Kocian, Roman; Kohler, Christhardt; Jarkovsky, Jiri; Klat, Jaroslav; Berjon, Alberto; Pilka, Radovan; Sehnal, Borek; Gil-Ibanez, Blanca; Lupo, Ezequiel; Petiz, Almerinda; Sanchez, Octavio Arencibia; Kascak, Peter; Martinelli, Fabio; Buda, Alessandro; Presl, Jiri; Barahona, Marc; van Lonkhuijzen, Luc; Szatkowski, Wiktor; Minar, Lubos; Pakiz, Maja; Havelka, Pavel; Zorrero, Christina; Misiek, Marcin; Snyman, Leon Cornelius; Wydra, Dariusz; Vergote, Ignace; Vinnytska, Alla; Redecha, Mikulas; Michal, Martin; Tingulstad, Solveig Kristi; Kipp, Barbara; Szewczyk, Grzegorz; Toth, Robert; de Santiago Garcia, Francisco Javier; Coronado Martin, Pluvio Jesus; Poka, Robert; Tamussino, Karl; Luyckx, Mathieu; Fastrez, Maxime; Staringer, Juan Carlos; Germanova, Anna; Plaikner, Andrea; Bajsova, Sylva; Dundr, Pavel; Mallmann-Gottschalk, Nina; Cibula, David (Peer reviewed; Journal article, 2020)
      The quality of pathological assessment is crucial for the safety of patients with cervical cancer if pelvic lymph node dissection is to be replaced by sentinel lymph node (SLN) biopsy. Central pathology review of SLN ...

    • The central role of gastrin in gastric cancer 

      Waldum, Helge; Mjønes, Patricia Gjertrud (Peer reviewed; Journal article, 2023)
      The prevalence of gastric cancer has markedly declined, but due to the high mortality rates associated with gastric cancer, it is still a serious disease. The preferred classification of gastric cancer is according to ...

    • Centralizing a national pancreatoduodenectomy service: striking the right balance 

      Nymo, Linn Såve; Kleive, Dyre; Waardal, Kim; Bringeland, Erling Audun; Søreide, Jon Arne; Labori, Knut Jørgen; Mortensen, Kim Erlend; Søreide, Kjetil; Lassen, Kristoffer (Peer reviewed; Journal article, 2020)
      Background Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher‐volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus ...

    • Cerebellar mutism syndrome in children with brain tumours of the posterior fossa 

      Wibroe, Morten; Cappelen, Johan; Castor, Charlotte; Clausen, Niels; Grillner, Pernilla; Gudrunardottir, Thora; Gupta, Ramneek; Gustavsson, Bengt; Heyman, Mats; Holm, Stefan; Karppinen, Atte; Klausen, Camilla; Lönnqvist, Tuula; Mathiasen, Rene; Nilsson, Pelle; Nysom, Karsten; Persson, Karin; Rask, Olof; Schmiegelow, Kjeld; Sehested, Astrid; Thomassen, Harald; Tonning-Olsson, Ingrid; Zetterqvist, Barbara; Juhler, Marianne (Peer reviewed; Journal article, 2017)
      Background: Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of posterior ...

    • Cerebral cortical dimensions in headache sufferers aged 50-66 years: a population-based imaging study in the Nord-Trondelag Health Study (HUNT-MRI) 

      Husøy, Andreas Kattem; Håberg, Asta Kristine; Rimol, Lars Morten; Hagen, Knut; Vangberg, Torgil Riise; Stovner, Lars Jacob (Journal article; Peer reviewed, 2019)
      Based on previous clinic-based magnetic resonance imaging studies showing regional differences in the cerebral cortex between those with and without headache, we hypothesized that headache sufferers have a decrease in ...

    • Cerebrospinal fluid catecholamines in Alzheimer's disease patients with and without biological disease 

      Henjum, Kristi; Watne, Leiv; Godang, Kristin; Halaas, Nathalie Bodd; Eldholm, Rannveig Sakshaug; Blennow, Kaj; Zetterberg, Henrik; Saltvedt, Ingvild; Bollerslev, Jens; Knapskog, Anne Brita (Journal article; Peer reviewed, 2022)
      Noradrenergic and dopaminergic neurons are involved in cognitive functions, relate to behavioral and psychological symptoms in dementia and are affected in Alzheimer’s disease (AD). Amyloid plaques (A), neurofibrillary ...

    • Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging 

      Loeffler, David A.; Klaver, Andrea C.; Coffey, Mary P.; Aasly, Jan (Peer reviewed; Journal article, 2018)
      Autophagy removes both functional and damaged intracellular macromolecules from cells via lysosomal degradation. Three autophagic mechanisms, namely macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy, ...

    • Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study 

      Schou, Morten Brix; Larsen, Jeanette Brun; Stunes, Astrid Kamilla; Sæther, Sverre Georg (Peer reviewed; Journal article, 2022)
      Central nervous system inflammation might play a role in patients with depressive disorders. This hypothesis is supported by studies reporting increased cerebrospinal fluid levels of the inflammatory markers interleukin ...

    • Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults 

      Hemminghyth, Mathilde Suhr; Chwiszczuk, Luiza; Breitve, Monica Haraldseid; Gisladottir, Berglind; Grøntvedt, Gøril Rolfseng; Nakling, Arne Exner; Rongve, Arvid; Fladby, Tormod; Kirsebom, Bjørn-Eivind Seljelid (Peer reviewed; Journal article, 2023)
      Multiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a ...

    • Cerebrospinal fluid sTREM2 in Alzheimer’s disease: comparisons between clinical presentation and AT classification 

      Knapskog, Anne Brita; Henjum, Kristi; Idland, Ane-Victoria; Eldholm, Rannveig Sakshaug; Persson, Karin Ester Torun; Saltvedt, Ingvild; Watne, Leiv; Engedal, Knut; Nilsson, Lars N.G. (Peer reviewed; Journal article, 2020)
      Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by microglia. Its cleaved fragments, soluble TREM2 (sTREM2), can be measured in the cerebrospinal fluid (CSF). Previous studies ...

    • Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial 

      Østergaard, Mikkel; Van Vollenhoven, Ronald F; Rudin, Anna; Hetland, Merete Lund; Schrumpf, Marte; Nordström, Dan C; Nurmohamed, Michael T; Gudbjornsson, Bjorn; Ørnbjerg, Lykke Midtbøll; Bøyesen, Pernille; Lend, Kristina; Hørslev-Petersen, Kim; Uhlig, Till; Sokka, Tuulikki; Grondal, Gerdur; Krabbe, Simon; Lindqvist, Joakim; Gjertsson, Inger; Glinatsi, Daniel; Kapetanovic, Meliha Crnkic; Aga, Anna-Birgitte; Faustini, Francesca; Parmanne, Pinja; Lorenzen, Tove; Giovanni, Cagnotto; Back, Johan; Hendricks, Oliver; Vedder, Daisy; Rannio, Tuomas; Grenholm, Emma; Ljoså, Maud-Kristine Aga; Brodin, Eli; Lindegaard, Hanne; Söderbergh, Annika; Rizk, Milad; Kastbom, Alf; Larsson, Per; Uhrenholt, Line; Just, Søren Andreas; Stevens, David John; Bay Laurbjerg, Trine; Bakland, Gunnstein; Olsen, Inge Christoffer; Haavardsholm, Espen A.; Lampa, Jon (Peer reviewed; Journal article, 2023)
      Background - The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with ...

    • The challenges of selective fertility and carryover effects in within-sibship analyses: the effect of assisted reproductive technology on perinatal mortality as an example 

      Westvik-Johari, Kjersti; Håberg, Siri Eldevik; Lawlor, Deborah A.; Romundstad, Liv Bente Bergem; Bergh, Christina; Wennerholm, Ulla-Britt; Gissler, Mika; Henningsen, Anna-Karina A.; Tiitinen, Aila; Pinborg, Anja; Opdahl, Signe (Peer reviewed; Journal article, 2023)
      Background Within-sibship analyses show lower perinatal mortality after assisted reproductive technology (ART) compared with natural conception (NC), a finding that appears biologically unlikely. We investigated whether ...

    • Challenges with benchmarking of MDMA-assisted psychotherapy 

      Halvorsen, Joar Øveraas; Naudet, Florian; Cristea, Ioana A. (Peer reviewed; Journal article, 2021)
      To represent a treatment breakthrough, 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder (PTSD) should be evaluated against first-line psychological interventions or for ...