Browsing St. Olavs hospital by Title

Now showing items 1230-1249 of 2447

    • Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health 

      Wang, Geng; Bhatta, Laxmi; Moen, Gunn-Helen; Hwang, Liang-Dar; Kemp, John P.; Bond, Tom A.; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Evans, David M.; Warrington, Nicole M. (Peer reviewed; Journal article, 2021)
      Observational epidemiological studies have reported that higher maternal blood pressure (BP) during pregnancy is associated with increased future risk of offspring cardiometabolic disease. However, it is unclear whether ...

    • Investigating causal relations between sleep traits and risk of breast cancer in women: Mendelian randomisation study 

      Richmond, Rebecca C.; Anderson, Emma L.; Dashti, Hassan S.; Jones, Samuel E.; Lane, Jacqueline M.; Strand, Linn B; Brumpton, Ben Michael; Rutter, Martin K.; Wood, Andrew R.; Straif, Kurt; Relton, Caroline L.; Munafò, Marcus; Frayling, Timothy M.; Martin, Richard M.; Saxena, Richa; Weedon, Michael N.; Lawlor, Debbie A.; Smith, George Davey (Peer reviewed; Journal article, 2019)
      Objective To examine whether sleep traits have a causal effect on risk of breast cancer. Design Mendelian randomisation study. Setting UK Biobank prospective cohort study and Breast Cancer Association Consortium ...

    • Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study 

      Alme, Katinka Nordheim; Askim, Torunn; Assmus, Jörg; Mollnes, Tom Eirik; Naik, Mala; Næss, Halvor; Saltvedt, Ingvild; Ueland, Per-Magne; Ulvik, Arve; Knapskog, Anne-Brita (Peer reviewed; Journal article, 2021)
      Background Sedentary behaviour is associated with disease, but the molecular mechanisms are not understood. Valid biomarkers with predictive and explanatory properties are required. Therefore, we have investigated traditional ...

    • Investigating optimal β-cell-preserving treatment in latent autoimmune diabetes in adults: Results from a 21-month randomized trial 

      Hals, Ingrid Kathrin; Fleiner, Hanne Fiskvik; Reimers, Nina; Astor, Marianne; Filipsson, Karin; Ma, Zuheng; Grill, Valdemar Erik Robert; Björklund, Anneli (Peer reviewed; Journal article, 2019)
      Aims To compare outcomes of glucagon‐stimulated C‐peptide tests (GSCTs) in people with latent autoimmune diabetes in adults (LADA) after a 21‐month intervention with either insulin or the dipeptidyl peptidase‐4 inhibitor ...

    • Investigating survival, quality of life and cognition in PROton versus photon therapy for IDH- mutated diffuse grade 2 and 3 GLIOmas (PRO-GLIO): a randomised controlled trial in Norway and Sweden 

      Heggebø, Liv Cathrine; Borgen, Ida Maria Henriksen; Rylander, Hillevi; Kiserud, Cecilie E.; Nordenmark, Tonje Kristin Haug; Hellebust, Taran Annette Paulsen; Evensen, Morten Egeberg; Gustavsson, Magnus; Ramberg, Christina; Sprauten, Mette; Magelssen, Henriette; Blakstad, Hanne; Moorthy, Janani; Andersson, Karin; Raunert, Ingela; Henry, Thomas; Moe, Cecilie; Granlund, Carin; Goplen, Dorota; Brekke, Jorunn; Johannessen, Tor-Christian Aase; Solheim, Tora S; Marienhagen, Kirsten; Humberset, Øyvind; Bergström, Per; Agrup, Måns; Dahl, Ludvig; Gubanski, Michael; Gojon, Helene; Brahme, Carl-Johan; Rydén, Isabelle; Jakola, Asgeir Store; Vik-Mo, Einar O.; Lie, Hanne Cathrine; Asphaug, Lars; Hervani, Maziar; Kristensen, Ingrid; Rüegg, Corina Silvia; Olsen, Inge Christoffer; Ledal, Rolf J; Degsell, Eskil; Werlenius, Katja; Blomstrand, Malin; Brandal, Petter (Peer reviewed; Journal article, 2023)
      Abstract Introduction The use of proton therapy increases globally despite a lack of randomised controlled trials demonstrating its efficacy and safety. Proton therapy enables sparing of non-neoplastic tissue from ...

    • Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study 

      Arora, Nikhil; Bhatta, Laxmi; Skarpsno, Eivind Schjelderup; Dalen, Håvard; Åsvold, Bjørn Olav; Brumpton, Ben Michael; Richmond, Rebecca C.; Strand, Linn Beate (Peer reviewed; Journal article, 2023)
      Background Few studies have investigated the joint effects of sleep traits on the risk of acute myocardial infarction (AMI). No previous study has used factorial Mendelian randomization (MR) which may reduce confounding, ...

    • Investigating the effect of sex and ketosis on weight-loss-induced changes in appetite 

      Lyngstad, Anna; Nymo, Siren; Coutinho, Silvia; Rehfeld, Jens F.; Truby, Helen; Kulseng, Bård Eirik; Martins, Catia (Peer reviewed; Journal article, 2019)
      Background Diet-induced weight loss (WL) is usually accompanied by increased appetite, a response that seems to be absent when ketogenic diets are used. It remains unknown if sex modulates the appetite suppressant effect ...

    • Investigation to identify individual socioeconomic and health determinants of suicidal ideation using responses to a cross-sectional, community-based public health survey 

      Mulholland, Helen; McIntyre, Jason C.; Haines, Alina; Whittington, Richard; Comerford, Terence; Corcoran, Rhiannon (Peer reviewed; Journal article, 2021)
      Abstract Objectives To address a gap in knowledge by simultaneously assessing a broad spectrum of individual socioeconomic and potential health determinants of suicidal ideation (SI) using validated measures in a large UK ...

    • Ipilimumab in a real-world population: A prospective Phase IV trial with long-term follow-up 

      Aamdal, Elin; Jacobsen, Kari Dolven; Straume, Oddbjørn; Kersten, Christian; Herlofsen, Oluf; Karlsen, Jarle; Hussain, Israr; Amundsen, Anita; Dalhaug, Astrid; Nyakas, Marta Sølvi; Schuster, Cornelia; Hagene, Kirsten Thorin; Holmsen, Kjersti; Russnes, Hege Elisabeth Giercksky; Skovlund, Eva; Kaasa, Stein; Aamdal, Steinar; Kyte, Jon A.; Guren, Tormod Kyrre (Peer reviewed; Journal article, 2021)
      Ipilimumab was the first treatment that improved survival in advanced melanoma. Efficacy and toxicity in a real-world setting may differ from clinical trials, due to more liberal eligibility criteria and less intensive ...

    • Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament 

      Yang, Yang; Pullisaar, Helen; Stunes, Astrid Kamilla; Parreiras Nogueira, Liebert; Syversen, Unni; Reseland, Janne Elin (Peer reviewed; Journal article, 2023)
      Objectives Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in ...

    • Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study 

      Mohus, Randi Marie; Flatby, Helene Marie; Liyanarachi, Kristin Vardheim; DeWan, Andrew T.; Solligård, Erik; Damås, Jan Kristian; Åsvold, Bjørn Olav; Gustad, Lise Tuset; Rogne, Tormod (Journal article; Peer reviewed, 2022)

    • Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

      Anderson, Emma L.; Richmond, Rebecca C.; Jones, Samuel E.; Hemani, Gibran; Wade, Kaitlin H; Dashti, Hassan S.; Lane, Jaqueline; Wang, Heming; Saxena, Richa; Brumpton, Ben Michael; Korologou-Linden, Roxanna; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Abecasis, Goncalo; Coulthard, Elizabeth; Kyle, Simon D.; Beaumont, Robin N.; Tyrell, Jessica; Frayling, Timothy M; Munafo, Marcus R; Wood, Andrew R; Ben-Shlomo, Yoav; Howe, Laura D; Lawlor, Deborah A.; Weedon, Michael N; Smith, George Davey (Peer reviewed; Journal article, 2020)
      Background It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...

    • Is foot deformity associated with developmental dysplasia of the hip? 

      Håberg, Øyvind; Foss, Olav A.; Lian, Øystein Bjerkestrand; Holen, Ketil Jarl (Peer reviewed; Journal article, 2020)
      Aims: To assess if congenital foot deformity is a risk factor for developmental dysplasia of the hip (DDH). Methods: Between 1996 and 2012, 60,844 children were born in Sør-Trøndelag county in Norway. In this cohort study, ...

    • Is Frailty Index a better predictor than pre-stroke modified Rankin Scale for neurocognitive outcomes 3-months post-stroke? 

      Munthe-Kaas, Ragnhild; Aam, Stina; Saltvedt, Ingvild; Wyller, Torgeir Bruun; Pendlebury, Sarah T.; Lydersen, Stian; Hagberg, Guri; SCHELLHORN, TILL; Rostoft, Siri; Ihle-Hansen, Hege (Peer reviewed; Journal article, 2022)
      Background The prognostic value of frailty measures for post-stroke neurocognitive disorder (NCD) remains to be evaluated. Aims The aim of this study was to compare the predictive value of pre-stroke FI with pre-stroke ...

    • Is intracranial volume a risk factor for IDH-mutant low-grade glioma? A case-control study 

      Sagberg, Lisa Millgård; Fyllingen, Even Hovig; Hansen, Tor Ivar; Strand, Per Sveino; Håvik, Aril Løge; Sundstrøm, Terje; Corell, Alba; Jakola, Asgeir Store; Salvesen, Øyvind; Solheim, Ole (Peer reviewed; Journal article, 2022)
      Purpose Risk of cancer has been associated with body or organ size in several studies. We sought to investigate the relationship between intracranial volume (ICV) (as a proxy for lifetime maximum brain size) and risk of ...

    • Is long-bout sedentary behaviour associated with long-Term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study 

      Alme, Katinka Nordheim; Knapskog, Anne Brita; Næss, Halvor; Naik, Mala; Beyer, Mona K.; Ellekjær, Hanne; English, Coralie; Ihle-Hansen, Hege; Kummeneje, Camilla S.; Munthe-Kaas, Ragnhild; Saltvedt, Ingvild; Seljeseth, Yngve Müller; Tan, Xiang chun; Thingstad, Pernille; Askim, Torunn (Peer reviewed; Journal article, 2020)
      Background and purpose Sedentary behaviour is a risk factor for vascular disease and stroke patients are more sedentary than their age-matched peers. The association with glucose levels, as a potential mediator, is unclear, ...

    • Is pituitary MRI screening necessary in cluster headache? 

      Grangeon, Lou; OConnor, Emer; Danno, Daisuke; Ngoc, Thanh Mai Pham; Cheema, Sanjay; Tronvik, Erling Andreas; Davagnanam, Indran; Matharu, Manjit (Peer reviewed; Journal article, 2021)
      Objective To determine the prevalence and clinical predictors of pituitary adenomas in cluster headache patients, in order to determine the necessity of performing dedicated pituitary magnetic resonance imaging in patients ...

    • Is police investigation of rape biased by characteristics of victims? 

      Vik, Bjarte Frode; Rasmussen, Kirsten; Schei, Berit; Hagemann, Cecilie Therese (Peer reviewed; Journal article, 2020)
      Aim To explore differences in police investigations between cases of rape against women with and without vulnerability factors. Methods Retrospective, descriptive study of cases of rape against women ≥16 years of age. ...

    • Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis? 

      Skjulsvik, Anne Jarstein; Bø, Hans Kristian; Jakola, Asgeir S; Berntsen, Erik Magnus; Bø, Lars Eirik; Reinertsen, Ingerid; Myrmel, Kristin Smistad; Sjåvik, Kristin; Åberg, Kristin; Berg, Thomas; Hong, Yan Dai; Kloster, Roar; Torp, Sverre Helge; Solheim, Ole (Peer reviewed; Journal article, 2020)
      Introduction According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) ...

    • Is there a causal relationship between stress and migraine? Current evidence and implications for management 

      Stubberud, Anker; Buse, Dawn C.; Kristoffersen, Espen Saxhaug; Linde, Mattias; Tronvik, Erling Andreas (Peer reviewed; Journal article, 2021)
      Background The purpose of this narrative review is to examine the literature investigating a causal relationship between stress and migraine and evaluate its implications for managing migraine. Methods PubMed, PsycINFO and ...