Browsing St. Olavs hospital by Title
Now showing items 1519-1538 of 2530
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Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries
(Peer reviewed; Journal article, 2023)Stroke is the second leading cause of death and disability worldwide. Stroke prevalence varies by sex and ancestry, possibly due to genetic heterogeneity between subgroups. We performed a genome-wide meta-analysis of 16 ... -
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
(Peer reviewed; Journal article, 2022)A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ... -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
(Journal article; Peer reviewed, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ... -
Multi-timescale microscopy methods for the characterization of fluorescently-labeled microbubbles for ultrasound-triggered drug release
(Peer reviewed; Journal article, 2021)Microbubble contrast agents hold great promise for drug delivery applications with ultrasound. Encapsulating drugs in nanoparticles reduces systemic toxicity and increases circulation time of the drugs. In a novel approach ... -
Multifactorial assessment of Parkinson’s disease course and outcomes using trajectory modeling in a multiethnic, multisite cohort – extension of the LONG-PD study
(Peer reviewed; Journal article, 2023)Background: The severity, progression, and outcomes of motor and non-motor symptoms in Parkinson’s disease (PD) are quite variable. Following PD cohorts holds promise for identifying predictors of disease severity and ... -
Multimodal Analysis of Secondary Cerebellar Alterations After Pediatric Traumatic Brain Injury
(Peer reviewed; Journal article, 2023)IMPORTANCE: Traumatic brain injury (TBI) is known to cause widespread neural disruption in the cerebrum. However, less is known about the association of TBI with cerebellar structure and how such changes may alter executive ... -
Multimodal individualised intervention to prevent functional decline after stroke: protocol of a randomised controlled trial on long-term follow-up after stroke (LAST-long)
(Peer reviewed; Journal article, 2023)Introduction Multimodal interventions have emerged as new approaches to provide more targeted intervention to reduce functional decline after stroke. Still, the evidence is contradictory. The main objective of the Life ... -
A multiomics disease progression signature of low-risk ccRCC
(Peer reviewed; Journal article, 2022)Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer. Identification of ccRCC likely to progress, despite an apparent low risk at the time of surgery, represents a key clinical issue. From a cohort of ... -
Multiparametric Prostate MRI in Biopsy-Naïve Men: A Prospective Evaluation of Performance and Biopsy Strategies
(Peer reviewed; Journal article, 2021)Objectives: This study aims to prospectively estimate the diagnostic performance of multiparametric prostate MRI (mpMRI) and compare the detection rates of prostate cancer using cognitive targeted transrectal ultrasound ... -
Multiple psychological senses of community and community influences on personal recovery processes from substance use problems in later life: a collaborative and deductive reflexive thematic analysis
(Peer reviewed; Journal article, 2023)Purpose There is a pressing need for substance use services to know more about how to promote recovery from substance use problems, particularly in later life. Psychological sense of community (PSOC) is an important ... -
Multiple senses of community and recovery processes. A pilot study for a national evaluation of the experiences of persons with substance use problems receiving help and services from Norwegian municipalities
(Peer reviewed; Journal article, 2019)Aims This pilot study uses a multifaceted concept of sense of community (SOC)—multiple senses of community (MPSOC)—to understand how the multiple communities of persons with substance use problems, including those with a ... -
Multiple-echo steady-state (MESS): Extending DESS for joint T2 mapping and chemical-shift corrected water-fat separation
(Peer reviewed; Journal article, 2021)Purpose - To extend the double echo steady-state (DESS) sequence to enable chemical-shift corrected water-fat separation. Methods - This study proposes multiple-echo steady-state (MESS), a sequence that modifies the ... -
Multippel erythema migrans, borrelialymfocytom og nevroborreliose hos eit barn
(Peer reviewed; Journal article, 2023) -
Mutasjonstesting ved ikke-småcellet lungekreft
(Peer reviewed; Journal article, 2012)BAKGRUNN. Epidermal vekstfaktor-reseptor (EGFR) tyrosinkinasehemmere (EGFR-TKI) er en relativt ny klasse legemidler til behandling av ikke-småcellet lungekreft. Den nasjonale faggruppen for lungekreft, Norsk Lunge Cancer ... -
Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced astroenteropancreatic Neuroendocrine Carcinoma
(Peer reviewed; Journal article, 2023)Purpose Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are rare and have a poor prognosis. Most GEP-NEC are diagnosed with metastatic disease, with only minor biopsies available for molecular diagnostics. We ... -
Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines
(Peer reviewed; Journal article, 2022)Introduction: Multiple myeloma (MM) is a heterogeneous disease where cancer-driver mutations and aberrant signaling may lead to disease progression and drug resistance. Drug responses vary greatly, and there is an unmet ... -
Mutational signature analysis reveals NTHL1 deficiency to cause a multi-tumor phenotype
(Peer reviewed; Journal article, 2019)Biallelic germline mutations affecting NTHL1 predispose carriers to adenomatous polyposis and colorectal cancer, but the complete phenotype is unknown. We describe 29 individuals carrying biallelic germline NTHL1 mutations ... -
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool
(Peer reviewed; Journal article, 2020)MutT homologue 1 (MTH1) removes oxidized nucleotides from the nucleotide pool and thereby prevents their incorporation into the genome and thereby reduces genotoxicity. We previously reported that MTH1 is an efficient ...