• Low C-peptide together with a high glutamic acid decarboxylase autoantibody level predicts progression to insulin dependence in latent autoimmune diabetes in adults: The HUNT study 

      Sørgjerd, Elin P.; Åsvold, Bjørn O.; Grill, Valdemar (Journal article; Peer reviewed, 2021)
      Aim: To search for risk factors that could predict progression in latent autoimmune diabetes in adults (LADA) and compare them with those for type 2 diabetes. Materials and Methods: This study included 175 participants ...
    • Low dose apixaban as secondary prophylaxis of venous thromboembolism in cancer patients – 30 months follow-up 

      Larsen, Trine-Lise; Garresori, Herish; Brekke, Jorunn; Enden, Tone Rønnaug; Frøen, Hege; Jacobsen, Eva-Marie; Quist-Paulsen, Petter; Porojnicu, Alina Carmen; Ree, Anne Hansen; Torfoss, Dag; Velle, Elin Osvik; Wik, Hilde Skuterud; Ghanima, Waleed; Sandset, Per Morten; Dahm, Anders Erik A (Peer reviewed; Journal article, 2022)
      Background - There are no data on the effect of low‐dose anticoagulation as secondary prophylaxis for venous thromboembolism (VTE) in cancer patients. We assessed the efficacy and safety of low‐dose apixaban for 30 months, ...
    • Low frequency cerebral arterial and venous flow oscillations in healthy neonates measured by NeoDoppler 

      Ødegård, Siv Steinsmo; Torp, Hans; Follestad, Turid; Leth-Olsen, Martin; Støen, Ragnhild; Nyrnes, Siri Ann (Peer reviewed; Journal article, 2022)
      Background: A cerebroprotective effect of low frequency oscillations (LFO) in cerebral blood flow (CBF) has been suggested in adults, but its significance in neonates is not known. This observational study evaluates normal ...
    • Low serum lipocalin-2 in pregnant women with systemic lupus erythematosus 

      Pedersen, Tina Therese; Fenstad, Mona H.; Wallenius, Marianne; Hetlelid, Elisabeth; Follestad, Turid; Langaas, Mette; Haug, Markus (Peer reviewed; Journal article, 2023)
      OBJECTIVES: Systemic lupus erythematosus (SLE) pregnancies are considered high-risk due to risk of disease flare and pregnancy complications. A more in-depth understanding of the immunological alterations in SLE patients ...
    • Low thyroid function is not associated with an accelerated deterioration in renal function 

      Meuwese, Christiaan L.; van Diepen, Merel; Cappola, Anne R.; Sarnak, Mark J.; Shlipak, Michael G.; Bauer, Douglas C.; Fried, Linda P.; Iacoviello, Massimo; Vaes, Bert; Degryse, Jean; Khaw, Kay-Tee; Luben, Robert N.; Åsvold, Bjørn Olav; Bjøro, Trine; Vatten, Lars Johan; de Craen, Anton J.M.; Trompet, Stella; Iervasi, Giorgio; Molinaro, Sabrina; Ceresini, Graziano; Ferrucci, Luigi; Dullaart, Robin P.F.; Bakker, Stephan J.L.; Jukema, J. Wouter; Kearney, Patricia M.; Stott, David J.; Peeters, Robin P.; Franco, Oscar H.; Völzke, Henry; Walsh, John P.; Bremner, Alexandra; Sgarbi, José A.; Maciel, Rui M.B.; Imaizumi, Misa; Ohishi, Waka; Dekker, Friedo W.; Rodondi, Nicolas; Gussekloo, Jacobijn; den Elzen, Wendy P.J. (Peer reviewed; Journal article, 2019)
      Background Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the ...
    • Low vitamin D, but not tobacco use or high BMI, is associated with long-term disability progression in multiple sclerosis 

      Wesnes, Kristin; Myhr, Kjell-Morten; Riise, Trond; Stokke, Silje Agnethe; Torkildsen, Øivind; Wergeland, Stig; Holmøy, Trygve; Midgard, Rune; Bru, Alla Nikolajevna S; Edland, Astrid; Eikeland, Randi; Gosal, Sonia; Harbo, Hanne Flinstad; Kleveland, Grethe; Sørenes, Yvonne; Øksendal, Nina; Bjørnevik, Kjetil Lauvland (Peer reviewed; Journal article, 2021)
      Background: Low vitamin D levels, tobacco use and high body mass index (BMI) have been linked to adverse disease outcomes in multiple sclerosis (MS), but their influence on long-term disability progression remains unclear. ...
    • Low-voltage electrical accidents, immediate reactions and acute health care associated with self-reported general health 4 years later 

      Goffeng, Lars Ole; Skare, Øivind; Brinchmann, Bendik Christian; Bjørnsen, Lars Petter Bache-Wiig; Veiersted, Kaj Bo (Journal article; Peer reviewed, 2022)
      Background and aims Electricians frequently experience low-voltage electrical accidents. Some such accidents involve long-term negative health consequences. Early identification of victims at risk for long-term injury may ...
    • Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness 

      Andreou, Dimitrios; Steen, Nils Eiel; Jørgensen, Kjetil Nordbø; Smelror, Runar Elle; Wedervang-Resell, Kirsten; Nerland, Stener; Westlye, Lars Tjelta; Nærland, Terje; Myhre, Anne Margrethe; Joa, Inge; Reitan, Solveig Merete Klæbo; Vaaler, Arne; Morken, Gunnar; Bøen, Erlend; Elvsåshagen, Torbjørn; Boye, Birgitte; Malt, Ulrik Fredrik; Aukrust, Pål; Skrede, Silje; Kroken, Rune Andreas; Johnsen, Erik; Djurovic, Srdjan; Andreassen, Ole; Ueland, Thor; Agartz, Ingrid (Peer reviewed; Journal article, 2021)
      Background Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal ...
    • Lower Extremity Intermittent Negative Pressure for Intermittent Claudication. Follow-Up after 24 Weeks of Treatment 

      Hoel, Henrik; Pettersen, Erik Mulder; Høiseth, Lars Øivind; Mathiesen, Iacob; Seternes, Arne; Hisdal, Jonny (Peer reviewed; Journal article, 2021)
      Background Treatment with lower extremity intermittent negative pressure (INP) of -40 mm Hg for one hour twice daily for 12 weeks, increases walking capacity in patients with intermittent claudication (IC). However, the ...
    • Lower-Grade Gliomas: An Epidemiological Voxel-Based Analysis of Location and Proximity to Eloquent Regions 

      Gómez Vecchio, Tomás; Neimantaite, Alice; Corell, Alba; Bartek, Jiri; Jensdottir, Margret; Reinertsen, Ingerid; Solheim, Ole; Jakola, Asgeir S. (Peer reviewed; Journal article, 2021)
      Background: Glioma is the most common intra-axial tumor, and its location relative to critical areas of the brain is important for treatment decision-making. Studies often report tumor location based on anatomical taxonomy ...
    • Lower-Limb Lymphedema after Sentinel Lymph Node Biopsy in Cervical Cancer Patients 

      Cibula, David; Borcinova, Martina; Marnitz, Simone; Jarkovsky, Jiri; Klat, Jaroslav; Pilka, Radovan; Torne, Aureli; Zapardiel, Ignacio; Petiz, Almerinda; Lay, Laura; Sehnal, Borek; Ponce, Jordi; Felsinger, Michal; Arencibia-Sánchez, Octavio; Kascak, Peter; Zalewski, Kamil; Presl, Jiri; Palop-Moscardo, Alicia; Tingulstad, Solveig Kristi; Vergote, Ignace; Redecha, Mikulas; Fruhauf, Filip; Kohler, Christhardt; Kocian, Roman (Peer reviewed; Journal article, 2021)
      Background: To prospectively assess LLL incidence among cervical cancer patients treated by uterine surgery complemented by SLN biopsy, without PLND. Methods: A prospective study in 150 patients with stage IA1–IB2 cervical ...
    • Lung cancer biomarker testing: perspective from Europe 

      Thunnissen, Erik; Weynand, Birgit; Udovicic-Gagula, Dalma; Brcic, Luka; Szolkowska5, Malgorzata; Hofman, Paul; Smojver-Ježek, Silvana; Anttila, Sisko; Calabrese, Fiorella; Kern, Isidor; Skov, Birgit; Perner, Sven; Dale, Vibeke Grotnes; Eri, Zivka; Haragan, Alex; Leonte, Diana; Carvallo, Lina; Prince, Spasenja Savic; Nicholson, Siobhan; Sansano, Irene; Ryska, Ales (Peer reviewed; Journal article, 2020)
      A questionnaire on biomarker testing previously used in central European countries was extended and distributed in Western and Central European countries to the pathologists participating at the Pulmonary Pathology Society ...
    • Lung function and peak oxygen uptake in chronic obstructive pulmonary disease phenotypes with and without emphysema 

      Rasch-Halvorsen, Øystein; Steinshamn, Sigurd Loe; Langhammer, Arnulf; Hassel, Erlend; Brumpton, Ben Michael; Jenssen, Haldor; Spruit, Martijn A. (Journal article; Peer reviewed, 2021)
      Previous studies of associations of forced expiratory lung volume in one second (FEV1) with peak oxygen uptake (VO2peak) in chronic obstructive pulmonary disease (COPD) have not taken sex, age and height related variance ...
    • Lynch syndrome mutation spectrum in New South Wales, Australia, including 55 novel mutations 

      Sjursen, Wenche; McPhillips, Mary; Scott, Rodney J.; Talseth-Palmer, Bente (Peer reviewed; Journal article, 2016)
      Background Lynch syndrome, the most frequent hereditary colorectal cancer syndrome, is caused by defects in mismatch repair genes. Genetic testing is important in order to identify mutation carriers who can benefit from ...
    • M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis 

      Brix, Ninna; Glerup, Mia; Thiel, Steffen; Mistegaard, Clara Elbæk; Skals, Regitze Gyldenholm; Berntson, Lillemor; Fasth, Anders; Nielsen, Susan Mary; Nordal, Ellen Berit; Rygg, Marite; Hasle, Henrik; Albertsen, Birgitte Klug; Herlin, Troels (Peer reviewed; Journal article, 2021)
      Objective: Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALLarthropathy) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of ...
    • Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury 

      Gravesteijn, BY; Nieboer, Daan; Ercole, Ari; Lingsma, Hester F; Nelson, David; Van Calster, Ben; Steyerberg, Ewout W; Andelic, Nada; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Peer reviewed; Journal article, 2020)
      Objective We aimed to explore the added value of common machine learning (ML) algorithms for prediction of outcome for moderate and severe traumatic brain injury. Study Design and Setting We performed logistic regression ...
    • Machine learning augmented reduced-order models for FFR-prediction 

      Fossan, Fredrik Eikeland; Müller, Lucas O.; Sturdy, Jacob; Bråten, Anders Tjellaug; Jørgensen, Arve; Wiseth, Rune; Hellevik, Leif Rune (Peer reviewed; Journal article, 2021)
      Computational predictions in cardiovascular medicine have largely relied on explicit models derived from physical and physiological principles. Recently, the application of artificial intelligence in cardiovascular medicine ...
    • Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial 

      Rakaee, Mehrdad; Andersen, S.; Giannikou, K.; Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Berg, Thomas; Richardsen, Elin; Lombardi, Ana Paola; Adib, E.; Pedersen, Mona Irene; Tafavvoghi, Masoud; Wahl, Sissel Gyrid Freim; Petersen, R.H.; Bondgaard, A.L.; Yde, C.W.; Baudet, C.; Licht, P.; Lund-Iversen, Marius; Grønberg, Bjørn Henning; Fjellbirkeland, Lars; Helland, Åslaug; Pøhl, M.; Kwiatkowski, D.J.; Dønnem, Tom (Peer reviewed; Journal article, 2023)
      Background We aim to implement an immune cell score model in routine clinical practice for resected non-small-cell lung cancer (NSCLC) patients (NCT03299478 ). Molecular and genomic features associated with immune ...
    • Machine prescription for chronic migraine 

      Stubberud, Anker; Gray, Robert; Tronvik, Erling Andreas; Matharu, Manjit Singh; Nachev, Parashkev (Peer reviewed; Journal article, 2022)
      Responsive to treatment individually, chronic migraine remains strikingly resistant collectively, incurring the second-highest population burden of disability worldwide. A heterogeneity of responsiveness, requiring ...
    • Macroscopic appearance of the major duodenal papilla influences bile duct cannulation: a prospective multicenter study by the Scandinavian Association for Digestive Endoscopy Study Group for ERCP 

      Haraldsson, Erik; Kylanpää, Leena; Grönroos, Juha; Saarela, Arto; Toth, Ervin; Qvigstad, Gunnar; Hult, Mari; Lindström, Outi; Laine, Simo; Karjula, Heikki; Hauge, Truls; Sadik, Riadh; Arnelo, Urban (Journal article, 2019)
      Background and Aims: Certain appearances of the major duodenal papilla have been claimed to make cannulation more difficult during ERCP. This study uses a validated classification of the endoscopic appearance of the major ...