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Centralizing a national pancreatoduodenectomy service: striking the right balance
(Peer reviewed; Journal article, 2020)Background Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher‐volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus ... -
Cerebellar mutism syndrome in children with brain tumours of the posterior fossa
(Peer reviewed; Journal article, 2017)Background: Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of posterior ... -
Cerebral cortical dimensions in headache sufferers aged 50-66 years: a population-based imaging study in the Nord-Trondelag Health Study (HUNT-MRI)
(Journal article; Peer reviewed, 2019)Based on previous clinic-based magnetic resonance imaging studies showing regional differences in the cerebral cortex between those with and without headache, we hypothesized that headache sufferers have a decrease in ... -
Cerebrospinal fluid catecholamines in Alzheimer's disease patients with and without biological disease
(Journal article; Peer reviewed, 2022)Noradrenergic and dopaminergic neurons are involved in cognitive functions, relate to behavioral and psychological symptoms in dementia and are affected in Alzheimer’s disease (AD). Amyloid plaques (A), neurofibrillary ... -
Cerebrospinal Fluid Concentration of Key Autophagy Protein Lamp2 Changes Little During Normal Aging
(Peer reviewed; Journal article, 2018)Autophagy removes both functional and damaged intracellular macromolecules from cells via lysosomal degradation. Three autophagic mechanisms, namely macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy, ... -
Cerebrospinal fluid cytokines in geriatric patients with depressive disorders: A retrospective case-control study
(Peer reviewed; Journal article, 2022)Central nervous system inflammation might play a role in patients with depressive disorders. This hypothesis is supported by studies reporting increased cerebrospinal fluid levels of the inflammatory markers interleukin ... -
Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults
(Peer reviewed; Journal article, 2023)Multiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a ... -
Cerebrospinal fluid sTREM2 in Alzheimer’s disease: comparisons between clinical presentation and AT classification
(Peer reviewed; Journal article, 2020)Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor expressed by microglia. Its cleaved fragments, soluble TREM2 (sTREM2), can be measured in the cerebrospinal fluid (CSF). Previous studies ... -
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
(Peer reviewed; Journal article, 2023)Background - The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological treatments with ... -
The challenges of selective fertility and carryover effects in within-sibship analyses: the effect of assisted reproductive technology on perinatal mortality as an example
(Peer reviewed; Journal article, 2023)Background Within-sibship analyses show lower perinatal mortality after assisted reproductive technology (ART) compared with natural conception (NC), a finding that appears biologically unlikely. We investigated whether ... -
Challenges with benchmarking of MDMA-assisted psychotherapy
(Peer reviewed; Journal article, 2021)To represent a treatment breakthrough, 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder (PTSD) should be evaluated against first-line psychological interventions or for ... -
Change in cardiovascular risk factors in patients who develop psoriatic arthritis: longitudinal data from the Nord-Trøndelag Health Study (HUNT)
(Journal article; Peer reviewed, 2018)Objectives The aim of this population-based study was to compare changes in cardiovascular (CV) risk factors over a decade-long period in patients who developed psoriatic arthritis (PsA) and the background population. Methods ... -
Change in Headache Suffering and Predictors of Headache after Mild Traumatic Brain Injury: A Population-Based, Controlled, Longitudinal Study with Twelve-Month Follow-Up
(Journal article; Peer reviewed, 2019)Headache attributed to traumatic injury to the head (HAIH) is claimed to be the most common sequela following mild traumatic brain injury (MTBI), but epidemiological evidence is scarce. We explored whether patients with ... -
Change in interpersonal problems and metacognitive beliefs as predictors of improvement in patients with generalized anxiety disorder
(Peer reviewed; Journal article, 2023)Introduction Generalized anxiety disorder (GAD) is characterized by persistent worry and anxiety, often with a chronic course. We tested the role of two suggested underlying factors in GAD, interpersonal problems and ... -
Change in physical activity and systolic blood pressure trajectories throughout mid-life and the development of dementia in older age: the HUNT study
(Peer reviewed; Journal article, 2023)Background There is lack of research on combinations of possible modifiable risk factors for dementia in a life-time perspective. Dementia has currently no cure, and therefore new knowledge of preventive factors is ... -
Change in quality of life and self-esteem in a randomized controlled CBT study for anxious and sad children: can targeting anxious and depressive symptoms improve functional domains in schoolchildren?
(Peer reviewed; Journal article, 2021)Background: Quality of life and self-esteem are functional domains that may suffer when having mental problems. In this study, we examined the change in quality of life and self-esteem when targeting anxious and depressive ... -
Change in Self-Reported Cognitive Symptoms After Mild Traumatic Brain Injury Is Associated With Changes in Emotional and Somatic Symptoms and Not Changes in Cognitive Performance
(Peer reviewed; Journal article, 2020)Objective: To investigate (a) whether self-reported cognitive symptoms after mild traumatic brain injury (MTBI) are associated with cognitive test performances, and (b) whether improvement in self-reported symptoms from 2 ... -
Changes in and predictors of pain and mortality in patients with chronic obstructive pulmonary disease
(Peer reviewed; Journal article, 2020)This longitudinal study of patients with chronic obstructive pulmonary disease (COPD) aimed to investigate changes in pain characteristics (i.e., occurrence, intensity, and interference) and covariates associated with pain ... -
Changes in C-reactive protein, neopterin and lactoferrin differ after conservative and surgical weight loss in individuals with morbid obesity
(Journal article; Peer reviewed, 2019)C-reactive protein, neopterin and lactoferrin are biomarkers of atherosclerotic disease. We aimed to assess changes in these biomarkers after conservative and surgical weight loss interventions in individuals with morbid ... -
Changes in cardiopulmonary exercise capacity and limitations 3 to 12 months after COVID-19
(Journal article; Peer reviewed, 2022)