Blar i St. Olavs hospital på tittel

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    • Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin 

      Trouva, Anastasia; Alvarsson, Michael; Calissendorff, Jan; Åsvold, Bjørn Olav; Vanky, Eszter; Hirschberg, Angelica Lindén (Peer reviewed; Journal article, 2022)
      Objective: Polycystic ovary syndrome (PCOS) and hypothyroidism are related conditions, and both are associated with adverse pregnancy outcomes. Knowledge is lacking about the complex interaction between thyroid status and ...

    • Time to classify tumours of the stomach and the kidneys according to cell of origin 

      Waldum, Helge; Mjønes, Patricia (Peer reviewed; Journal article, 2021)
      Abstract: Malignant tumours are traditionally classified according to their organ of origin and whether they are of epithelial (carcinomas) or mesenchymal (sarcomas) origin. By histological appearance the site of origin ...

    • Time to diagnosis in young onset alzheimer's disease: A population-based study from central Norway 

      Kvello-Alme, Marte; Bråthen, Geir; White, Linda Rosemary; Sando, Sigrid Botne (Peer reviewed; Journal article, 2021)
      Background: Young onset dementia is associated with a longer time to diagnosis compared to late onset dementia. Earlier publications have indicated that atypical presentation is a key contributing factor to the diagnostic ...

    • Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL-1ra and IL-1 beta is associated with progressive disease 

      Hals, Ingrid Kathrin; Björklund, Anneli; Fleiner, Hanne Fiskvik; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2022)
      Background Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been ...

    • Time-dependent effects on circulating cytokines in patients with LADA: A decrease in IL1-ra and IL-1 beta is associated with progressive disease 

      Hals, Ingrid Kathrin; Björklund, Anneli; Fleiner, Hanne Fiskvik; Grill, Valdemar Erik Robert (Peer reviewed; Journal article, 2022)
      Background - Cytokines and chemokines participate in autoimmune processes at cellular targets which include insulin-producing beta cells. To which extent such participation is reflected in the circulation has not been ...

    • Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial 

      La Haganes, Kamilla; Silva Ruiz, Catalina Paz; Eyjolfsdottir, Svala Kristfridur; Steen, Sandra; Grindberg, Martine; Lydersen, Stian; Hawley, John A; Moholdt, Trine Tegdan (Peer reviewed; Journal article, 2022)
      Summary Diet modification and exercise training are primary lifestyle strategies for obesity management, but poor adherence rates limit their effectiveness. Time-restricted eating (TRE) and high-intensity interval training ...

    • Timing of severe toxicity from chemotherapy in patients with lung cancer 

      Sjøgren, Kristina; Jacobsen, Kristian Aalberg; Grønberg, Bjørn Henning; Halvorsen, Tarje Onsøien (Journal article; Peer reviewed, 2020)
      Background/Aim: The aim of this study was to investigate the timing of severe toxicity in lung cancer patients receiving chemotherapy. Patients and Methods: Patients with advanced non-small cell lung cancer or limited ...

    • Tinder use and romantic relationship formations: A large-scale longitudinal sStudy 

      Erevik, Eilin K.; Kristensen, Joakim Hellumbråten; Torsheim, Torbjørn; Vedaa, Øystein; Pallesen, Ståle (Peer reviewed; Journal article, 2020)
      The current paper aims to investigate if Tinder use predicts romantic relationship formation 1 year later and to identify demographic, personality, mental health, and substance use covariates in the relationship between ...

    • TIRAP/Mal Positively Regulates TLR8‐Mediated Signaling via IRF5 in Human Cells 

      Nilsen, Kaja Elisabeth; Skjesol, Astrid; Kojen, June Frengen; Espevik, Terje; Stenvik, Jørgen; Yurchenko, Mariya (Peer reviewed; Journal article, 2022)
      Toll-like receptor 8 (TLR8) recognizes single-stranded RNA of viral and bacterial origin as well as mediates the secretion of pro-inflammatory cytokines and type I interferons by human monocytes and macrophages. TLR8, as ...

    • Tissue microstructure is linked to MRI parameters and metabolite levels in prostate cancer 

      Selnæs, Kirsten Margrete; Vettukattil, Muhammad Riyas; Bertilsson, Helena; Wright, Alan J.; Heerschap, Arend; Angelsen, Anders; Tessem, May-Britt; Bathen, Tone Frost (Peer reviewed; Journal article, 2016)
      Introduction: Magnetic resonance imaging (MRI) can portray spatial variations in tumor heterogeneity, architecture, and its microenvironment in a non-destructive way. The objective of this study was to assess the relationship ...

    • TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies 

      Gierman, Lobke; Silva, Gabriela; Pervaiz, Zahra; Rakner, Johanne Johnsen; Mundal, Siv Boon; Thaning, Astrid J.; Nervik, Ingunn; Elschot, Mattijs; Mathew, Seema; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2020)
      Inflammation and oxidative stress at the maternal‐fetal interface characterize the placental dysfunction that underlies the pregnancy disorder preeclampsia. Specialized fetal trophoblasts directly interact with leukocytes ...

    • The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2 

      Skjesol, Astrid; Yurchenko, Mariya; Bösl, Korbinian; Gravastrand, Caroline S.; Nilsen, Kaja Elisabeth; Grøvdal, Lene Melsæther; Agliano, Federica; Patane, Francesco; Lentini, Germana; Kim, Hera; Teti, Giuseppe; Sharma, Aditya Kumar; Kandasamy, Richard Kumaran; Sporsheim, Bjørnar; Starheim, Kristian K.; Golenbock, Douglas T.; Stenmark, Harald; McCaffrey, Mary; Espevik, Terje; Husebye, Harald (Peer reviewed; Journal article, 2019)
      Phagocytosis is a complex process that eliminates microbes and is performed by specialised cells such as macrophages. Toll-like receptor 4 (TLR4) is expressed on the surface of macrophages and recognizes Gram-negative ...

    • Tocilizumab increases citrullinated histone 3 in non-ST segment elevation myocardial infarction 

      Helseth, Ragnhild; Kleveland, Ola; Ueland, Thor; Wiseth, Rune; Damås, Jan Kristian; Broch, Kaspar; Michelsen, Annika Elisabet; Bendz, Bjørn; Gullestad, Lars; Aukrust, Pål; Seljeflot, Ingebjørg (Peer reviewed; Journal article, 2021)
      Objective Beyond reducing inflammation and troponin T (TnT) release, the interleukin-6 receptor antagonist tocilizumab reduces neutrophil counts in patients with non-ST segment elevation myocardial infarction (NSTEMI). It ...

    • Tofacitinib Downregulates TNF and Poly(I:C)-Dependent MHC-II Expression in the Colonic Epithelium 

      Gopalakrishnan, Shreya; Hansen, Marianne Dore; Skovdahl, Helene Kolstad; Roseth, Ingrid Aass; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2022)
      Major Histocompatibility Complex (MHC)-I and -II genes are upregulated in intestinal epithelial cells (IECs) during active inflammatory bowel diseases (IBD), but little is known about how IBD-relevant pro-inflammatory ...

    • Toileting difficulties in older people with and without dementia receiving formal in-home care-A longitudinal study 

      Grimsland, Frida; Seim, Arnfinn; Borza, Tom; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2019)
      Aim To estimate the prevalence of toileting difficulties over time among older people (≥70 years) with and without dementia receiving formal in‐home care at baseline and to explore whether dementia at baseline was ...

    • Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants 

      Eap, C.B.; Gründer, Gerhard; Baumann, P.; Ansermot, N.; Conca, A.; Corruble, E.; Crettol, S.; Dahl, Marja-Liisa; de Leon, Leon; Greiner, C.; Howes, Oliver D.; Kim, E.; Lanzenberger, R.; Meyer, J.H.; Moessner, R.; Mulder, H.; Müller, Daniel J.; Reis, Margareta; Riederer, P.; Ruhe, H.G.; Spigset, Olav; Spina, E.; Stegman, B.; Steimer, W.; Stingl, J.; Suzen, S.; Uchida, H.; Unterecker, S.; Vandenberghe, F.; Hiemke, C. (Peer reviewed; Journal article, 2021)
      Objectives: More than 40 drugs are available to treat affective disorders. Individual selection of the optimal drug and dose is required to attain the highest possible efficacy and acceptable tolerability for every patient. ...

    • Top Ten Tips Palliative Care Clinicians Should Know About Cachexia 

      Blum, David; Vagnildhaug, Ola Magne; Stene, Guro Birgitte; Maddocks, Matthew; Sørensen, Jonas; Laird, Barry J; Prado, Carla M.; Solheim, Tora S; Arends, Jann; Hopkinson, Jane; Jones, Christopher A.; Schlögl, Mathias (Peer reviewed; Journal article, 2023)
      Cachexia is a multifactorial syndrome that is common in cancer and chronic disease. It is often underdiagnosed and therefore goes untreated or undertreated. Cachexia causes suffering across biopsychosocial domains and ...

    • Total late effect burden in long-term lymphoma survivors after high-dose therapy with autologous stem-cell transplant and its effect on health-related quality of life 

      Smeland, Knut Bjøro; Holte, Harald; Fagerli, Unn-Merete; Bersvendsen, Hanne Skjerven; Hjermstad, Marianne Jensen; Loge, Jon Håvard; Murbræch, Klaus; Linnsund, Marianne Dahl; Fluge, Øystein; Stenehjem, Jo Steinson; Samersaw-Lund, May Brit; Kvaløy, Stein Olav; Kiserud, Cecilie E. (Peer reviewed; Journal article, 2022)
      Lymphoma survivors after high-dose therapy with autologous stem-cell transplant (HDT-ASCT) are at risk of several late effects, which might impair their health-related quality of life (HRQoL). We assessed the total late ...

    • Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group 

      Olsen, Alexander; Babikian, Talin; Bigler, Erin D.; Caeyenberghs, Karen; Conde, Virginia; Dams-O’Connor, Kristen; Dobryakova, Ekaterina; Genova, Helen; Grafman, Jordan; Håberg, Asta; Heggland, Ingrid; Hellstrøm, Torgeir; Hodges, Cooper B.; Irimia, Andrei; Jha, Ruchira M.; Johnson, Paula K.; Koliatsos, Vassilis E.; Levin, Harvey; Li, Lucia M.; Lindsey, Hannah M.; Livny, Abigail; Løvstad, Marianne; Medaglia, John; Menon, David; Mondello, Stefania; Monti, Martin M.; Newcombe, Virginia F.J.; Petroni, Agustin; Ponsford, Jennie; Sharp, David; Spitz, Gershon; Westlye, Lars Tjelta; Thompson, Paul M.; Dennis, Emily L.; Tate, David; Wilde, Elisabeth A.; Hillary, Frank G. (Peer reviewed; Journal article, 2020)
      The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major ...

    • Towards human-level performance on automatic pose estimation of infant spontaneous movements 

      Groos, Daniel; Adde, Lars; Støen, Ragnhild; Ramampiaro, Heri; Ihlen, Espen Alexander F. (Peer reviewed; Journal article, 2021)
      Assessment of spontaneous movements can predict the long-term developmental disorders in high-risk infants. In order to develop algorithms for automated prediction of later disorders, highly precise localization of segments ...