dc.contributor.author | Paulsen, Julie | |
dc.contributor.author | Askim, Åsa Susanne | |
dc.contributor.author | Mohus, Randi Marie | |
dc.contributor.author | Mehl, Arne | |
dc.contributor.author | Dewan, Andrew | |
dc.contributor.author | Solligård, Erik | |
dc.contributor.author | Damås, Jan Kristian | |
dc.contributor.author | Åsvold, Bjørn Olav | |
dc.date.accessioned | 2017-07-03T07:29:07Z | |
dc.date.available | 2017-07-03T07:29:07Z | |
dc.date.created | 2017-06-30T09:44:53Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0300-5771 | |
dc.identifier.uri | http://hdl.handle.net/11250/2447553 | |
dc.description.abstract | Background: Bloodstream infections (BSI) cause considerable morbidity and mortality, and primary prevention should be a priority. Lifestyle factors are of particular interest since they represent a modifiable target.
Methods: We conducted a prospective cohort study among participants in the population-based Norwegian HUNT2 Survey, where 64 027 participants were followed from 1995–97 through 2011 by linkage to prospectively recorded information on BSI at local and regional hospitals. The exposures were: baseline body mass index (BMI) measurements; and self-reported smoking habits, leisure time physical activity and alcohol intake. The outcomes were hazard ratios (HR) of BSI and BSI mortality.
Results: During 810 453 person-years and median follow-up of 14.8 years, 1844 (2.9%) participants experienced at least one BSI and 396 (0.62%) died from BSI. Compared with normal weight participants (BMI 18.5–24.9 kg/m2), the age- and sex-adjusted risk of a first-time BSI was 31% [95% confidence interval (CI) 14–51%] higher at BMI 30.0–34.9 kg/m2, 87% (95% CI 50–135%) higher at BMI 35.0–39.9 kg/m2 and 210% (95% CI 117–341%) higher at BMI ≥ 40.0 kg/m2. The risk of BSI mortality was similarly increased. Compared with never-smokers, current smokers had 51% (95% CI 34–70%) and 75% (95% CI 34–129%) higher risks of BSI and BSI mortality, respectively. Physically inactive participants had 71% (95% CI 42–107%) and 108% (95% CI 37–216%) higher risks of BSI and BSI mortality, respectively, compared with the most physically active. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Oxford University Press | nb_NO |
dc.relation.uri | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ije/PAP/10.1093_ije_dyx091/2/dyx091.pdf?Expires=1498902211&Signature=TbF47XuzY3YkFB2cbIx1M6kjR7~itLSw9xPW7c2h2e4OfF62QzqGmjtEkKtNQ3s | |
dc.title | Associations of obesity and lifestyle with the risk and mortality of bloodstream infection in a general population: a 15-year follow-up of 64 027 individuals in the HUNT Study | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | acceptedVersion | nb_NO |
dc.source.volume | 1 | nb_NO |
dc.source.journal | International Journal of Epidemiology | nb_NO |
dc.source.issue | 9 | nb_NO |
dc.identifier.doi | 10.1093/ije/dyx091 | |
dc.identifier.cristin | 1480049 | |
dc.relation.project | Norges forskningsråd: 223255 | nb_NO |
dc.description.localcode | © The Author 2017; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association. This is the authors' accepted and refereed manuscript to the article. Locked until 15 June 2018 due to copyright restrictions | nb_NO |
cristin.unitcode | 194,65,15,0 | |
cristin.unitcode | 194,65,15,30 | |
cristin.unitcode | 194,65,25,0 | |
cristin.unitcode | 194,65,20,0 | |
cristin.unitcode | 194,65,20,15 | |
cristin.unitname | Institutt for kreftforskning og molekylær medisin | |
cristin.unitname | Centre of Molecular Inflammation Research (SFF-CEMIR) | |
cristin.unitname | Institutt for sirkulasjon og bildediagnostikk | |
cristin.unitname | Institutt for samfunnsmedisin | |
cristin.unitname | Helseundersøkelsen i Nord-Trøndelag | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |