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Metabolic profiles of brain metastases

Sjøbakk, Torill Eidhammer; Vettukattil, Riyas M; Gulati, Michel; Gulati, Sasha; Lundgren, Steinar; Gribbestad, Ingrid S; Torp, Sverre Helge; Bathen, Tone Frost
Journal article, Peer reviewed
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ijms-14-02104.pdf (2.202Mb)
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http://hdl.handle.net/11250/2357214
Utgivelsesdato
2013
Metadata
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  • Institutt for klinisk og molekylær medisin [2067]
  • Institutt for nevromedisin og bevegelsesvitenskap [1709]
  • Institutt for sirkulasjon og bildediagnostikk [1048]
  • Publikasjoner fra CRIStin - NTNU [20842]
Originalversjon
International Journal of Molecular Sciences 2013, 14(1):2104-2118   10.3390/ijms14012104
Sammendrag
Metastasis to the brain is a feared complication of systemic cancer, associated

with significant morbidity and poor prognosis. A better understanding of the tumor

metabolism might help us meet the challenges in controlling brain metastases. The study

aims to characterize the metabolic profile of brain metastases of different origin using high

resolution magic angle spinning (HR-MAS) magnetic resonance spectroscopy (MRS) to

correlate the metabolic profiles to clinical and pathological information. Biopsy samples of

human brain metastases (n = 49) were investigated. A significant correlation between lipid

signals and necrosis in brain metastases was observed (p < 0.01), irrespective of their primary origin. The principal component analysis (PCA) showed that brain metastases

from malignant melanomas cluster together, while lung carcinomas were metabolically

heterogeneous and overlap with other subtypes. Metastatic melanomas have higher

amounts of glycerophosphocholine than other brain metastases. A significant correlation

between microscopically visible lipid droplets estimated by Nile Red staining and MR visible

lipid signals was observed in metastatic lung carcinomas (p = 0.01), indicating that the proton

MR visible lipid signals arise from cytoplasmic lipid droplets. MRS-based metabolomic

profiling is a useful tool for exploring the metabolic profiles of metastatic brain tumors.
Utgiver
MDPI
Tidsskrift
International Journal of Molecular Sciences

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