Kavliinstitutt for nevrovitenskap
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Volatile Relationships Signal interactions of CO2 and plant odorants in the primary olfactory processing center of the moth Helicoverpa armigera
(Master thesis, 2024)Karbondioksid er kjent for å være et viktig molekyl i mange insekters sanseverden, og møllen H. armigera er intet unntak. Denne studien undersøker signalinteraksjonene mellom CO2 og plantelukt-stoffer i en distinkt populasjon ... -
Molecular characterization of dexamethasone-induced protein-DEXI, encoded by a multiple sclerosis susceptibility gene
(Master thesis, 2024)Multippel sklerose er en nevrologisk autoimmune sykdom som påvirker det sentrale nervesystemet ved demyelinisering og tap av nevroner. Den underliggende årsaken er ukjent, men det er antatt å være et samspill mellom genetikk ... -
A novel approach to study the impact of reduced brain noradrenergic neuromodulation on transcriptome changes of cortical neurons and astrocytes
(Master thesis, 2024)Noradrenalin (NA) er eit viktig stoff som bidreg til å oppretthalde normal hjernefunksjon. NA er involvert i eit vidt spekter av funksjoner, mellom anna overgangar mellom ulike nivå av aktivitet i hjernen. Den viktigaste ... -
Dissection and culturing of adult lateral entorhinal cortex layer II neurons from APP/PS1 Alzheimer model mice
(Peer reviewed; Journal article, 2023)Background Primary neuronal cultures enable cell-biological studies of Alzheimer’s disease (AD), albeit typically non-neuron-specific. The first cortical neurons affected in AD reside in layer II of the lateralmost part ... -
Establishing a Radial Arm Maze Task to Investigate the Role of TDG in Hippocampus-Dependent Memory
(Master thesis, 2024)Identifiseringen av hippocampus (HPC) som sentrum for både eksplisitt hukommelse og romlig navigasjon har tilrettelagt for målrettede eksperimenter for å forstå mekanismene bak dannelsen av hukommelse. En bredt akseptert ... -
Cajal-Retzius cells and their influence on the neurotrophin signaling pathway in the hippocampal microcircuit
(Master thesis, 2024)Cajal Retzius (CR) celler er en midlertidig populasjon av nevroner hovedsakelig lokalisert i kortikale hjerneområder, inkludert hippocampus, avgjørende for kortikal utvikling. Til tross for deres vedvarende tilstedeværelse ... -
A longitudinal EEG study of visual motion perception in full-term and preterm infants and children
(Master thesis, 2024)High-density electroencephalogram (EEG) was utilized longitudinally to study brain electrical activity in 10 full-term and 10 preterm participants at 4 months, 12 months, and 6 years of age, by investigating visual motion ... -
Proteomic Study on Dentate Gyrus-Specific Growth Cones
(Master thesis, 2024)Vekstkjegler (VK) er dynamiske og svært tilpasningsdyktige strukturer lokalisert på tuppen av ethvert akson under utvikling. Mens de utforsker miljøet rundt, påvirkes atferden av kjemotaksis samtidig som de dirigerer aksonet ... -
Implementing a new method to study the connection of stellate cells to CA3 and Dentate Gyrus
(Master thesis, 2024)Entorhinal cortex ansees for å være et knutepunkt for informasjon som går inn og ut av hippocampus. Lag II og III av entorhinal cortex formidler informasjon fra cortex til hippocampus, mens lag V og VI formidler informasjon ... -
Population codes for space in the medial entorhinal cortex and hippocampus
(Doctoral theses at NTNU;2024:132, Doctoral thesis, 2024)Navigation and the ability to orient oneself in the external environment is fundamental for humans and other animals. The hippocampus and the medial entorhinal cortex (MEC) contain cells that are believed to support spatial ... -
Memory in the lab versus memory in the wild: How effectively do mechanisms generalize across contexts?
(Doctoral theses at NTNU;2024:162, Doctoral thesis, 2024)English summary A large portion of human interactions with the environment depends on the accurate estimation of spatial and temporal magnitudes in the order of seconds to minutes. Through these dynamic interactions, ... -
Association cortical areas in the mouse contain a large population of fast-spiking GABAergic neurons that do not express parvalbumin
(Journal article; Peer reviewed, 2024)GABAergic neurons represent 10–15% of the neuronal population of the cortex but exert a powerful control over information flow in cortical circuits. The largest GABAergic class in the neocortex is represented by the ... -
Functional properties of entorhinal-hippocampal circuits - A spacetime odyssey
(Doctoral theses at NTNU;2024:123, Doctoral thesis, 2024) -
Intracellular Amyloid-β in the Normal Rat Brain and Human Subjects and Its relevance for Alzheimer's Disease
(Journal article; Peer reviewed, 2023) -
Adaptive spike threshold dynamics associated with sparse spiking of hilar mossy cells are captured by a simple model
(Peer reviewed; Journal article, 2023)Hilar mossy cells (hMCs) in the dentate gyrus (DG) receive inputs from DG granule cells (GCs), CA3 pyramidal cells and inhibitory interneurons, and provide feedback input to GCs. Behavioural and in vivo recording experiments ... -
Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain
(Peer reviewed; Journal article, 2023)Background Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer's disease (AD). These beneficial effects may be partly mediated by blood-borne factors. ... -
Connecting the Dots: Integrating Visual Projections, Observational Learning, and Behavior Representation in Rodent Prefrontal Cortices
(Doctoral theses at NTNU;2024:17, Doctoral thesis, 2024)The medial prefrontal cortex (mPFC) has been studied extensively across species, across functions and across experimental paradigms. Despite this, we still have not fully elucidated what this brain area truly does and how, ... -
Multisensory input modulates memory-guided spatial navigation in humans
(Peer reviewed; Journal article, 2023)Efficient navigation is supported by a cognitive map of space. The hippocampus plays a key role for this map by linking multimodal sensory information with spatial memory representations. However, in human navigation ... -
Mental search of concepts is supported by egocentric vector representations and restructured grid maps
(Peer reviewed; Journal article, 2023)The human hippocampal-entorhinal system is known to represent both spatial locations and abstract concepts in memory in the form of allocentric cognitive maps. Using fMRI, we show that the human parietal cortex evokes ... -
Klotho and GPLD-1: Predictive Biomarkers for Development of Alzheimer's Disease in Older Adults
(Master thesis, 2023)Bakgrunn: Alzheimers sykdom (AD) er en nevrodegenerativ sykdom og den vanligste formen for demens. I 2023 påvirker demens over 55 millioner mennesker globalt, og det er forventet å øke til 152 millioner innen 2050. Likevel ...