• The long-term stability of new hippocampal place fields requires new protein synthesis. 

      Agnihotri, Naveen; Hawkins, Robert; Kandel, ER; Kentros, Clifford (Journal article; Peer reviewed, 2004)
      The hippocampus is critical for formation of spatial memories. Hippocampal pyramidal neurons in freely behaving animals exhibit spatially selective firing patterns, which taken together form an internal representation of ...
    • What is remembered? Role of attention on the encoding and retrieval of hippocampal representations 

      Muzzio, Isabel; Kentros, Clifford; Kandel, ER (Journal article; Peer reviewed, 2009)
      The hippocampus is critically involved in storing explicit memory such as memory for space. A defining feature of explicit memory storage is that it requires attention both for encoding and retrieval. Whereas, a great deal ...
    • The retrosplenial cortex: intrinsic connectiviuty and connections with the (para)hippocampal region in the rat. An interactive connectome 

      Sugar, Jørgen Larsen; Witter, Menno; van Strien, Niels; Cappaert, Natalie L.M. (Journal article; Peer reviewed, 2011)
      A connectome is an indispensable tool for brain researchers, since it quickly provides comprehensive knowledge of the brain’s anatomical connections. Such knowledge lies at the basis of understanding network functions. Our ...
    • Trans-Synaptic Spread of Tau Pathology In Vivo 

      Liu, L; Drouet, V; Wu, JW; Witter, Menno; Small, Scott A; Clelland, C; Duff, K (Journal article; Peer reviewed, 2012)
      Tauopathy in the brain of patients with Alzheimer’s disease starts in the entorhinal cortex (EC) and spreads anatomically in a defined pattern. To test whether pathology initiating in the EC spreads through the brain along ...
    • The Time Window for Generation of Dendritic Spikes by Coincidence of Action Potentials and EPSPs is Layer Specific in Somatosensory Cortex 

      Ledergerber, Debora; Larkum, Matthew Evan (Journal article; Peer reviewed, 2012)
      The precise timing of events in the brain has consequences for intracellular processes, synaptic plasticity, integration and network behaviour. Pyramidal neurons, the most widespread excitatory neuron of the neocortex have ...
    • Head direction maps remain stable despite grid map fragmentation 

      Whitlock, Jonathan Robert; Derdikman, Dori Moshe (Journal article; Peer reviewed, 2012)
      Areas encoding space in the brain contain both representations of position (place cells and grid cells) and representations of azimuth (head direction cells). Previous studies have already suggested that although grid cells ...
    • Increasing levels of wild-type CREB up-regulates several activity-regulated inhibitor of death (AID) genes and promotes neuronal survival 

      Tan, YW; Zhang, Sheng Jia; Hoffmann, T.; Bading, H (Journal article; Peer reviewed, 2012)
      Background CREB (cAMP-response element binding protein) is the prototypical signal-regulated transcription factor. In neurons, it is the target of the synaptic activity-induced nuclear calcium-calcium/calmodulin dependent ...
    • Organization of multisynaptic inputs to the dorsal and ventral dentate gyrus: retrograde trans-synaptic tracing with rabies virus vector in the rat 

      Ohara, S; Sato, S; Tsutsui, K; Witter, Menno; Iijima, Toshio (Journal article; Peer reviewed, 2013)
      Behavioral, anatomical, and gene expression studies have shown functional dissociations between the dorsal and ventral hippocampus with regard to their involvement in spatial cognition, emotion, and stress. In this study ...
    • The spatial representations acquired in CA3 by self-organizing recurrent connections 

      Cerasti, Erika; Treves, Alessandro (Journal article; Peer reviewed, 2013)
      Neural computation models have hypothesized that the dentate gyrus (DG) drives the storage in the CA3 network of new memories including, e.g., in rodents, spatial memories. Can recurrent CA3 connections self-organize, ...
    • Spatial Coding in the Hippocampal Region 

      Boccara, Charlotte (Doktoravhandlinger ved NTNU, 1503-8181; 2014:99, Doctoral thesis, 2014)
    • Coherence among Head Direction Cells before Eye Opening in Rat Pups 

      Bjerknes, Tale L.; Langston, Rosamund Fay; Kruge, Ingvild Ulsaker; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      Mammalian navigation is thought to depend on an internal map of space consisting of functionally specialized cells in the hippocampus and the surrounding parahippocampal cortices [1–7]. Basic properties of this map are ...
    • Navigating actions through the rodent parietal cortex 

      Whitlock, Jonathan (Journal article, 2014)
      The posterior parietal cortex (PPC) participates in a manifold of cognitive functions, including visual attention, working memory, spatial processing, and movement planning. Given the vast interconnectivity of PPC with ...
    • Grid cells and cortical representation 

      Moser, Edvard Ingjald; Roudi, Yasser; Witter, Menno; Kentros, Clifford; Bonhoeffer, Tobias; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      One of the grand challenges in neuroscience is to comprehend neural computation in the association cortices, the parts of the cortex that have shown the largest expansion and differentiation during mammalian evolution and ...
    • Architecture of spatial circuits in the hippocampal region 

      Witter, Menno; Canto, Cathrin Barbara; Couey, Jonathan Jay; Koganezawa, Noriko; O'Reilly, Kally (Journal article; Peer reviewed, 2014)
      The hippocampal region contains several principal neuron types, some of which show distinct spatial firing patterns. The region is also known for its diversity in neural circuits and many have attempted to causally relate ...
    • Functional diversity along the transverse axis of hippocampal area CA1 

      Igarashi, Kei M; Ito, Hiroshi; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      Decades of neuroscience research have shed lights on the hippocampus as a key structure for the formation of episodic memory. The hippocampus is divided into distinct subfields – CA1, CA2 and CA3. Whereas accumulating ...
    • Coordination of entorhinal-hippocampal ensemble activity during associative learning 

      Igarashi, Kei M; Lu, Li; Colgin, Laura Lee; Moser, May-Britt; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2014)
      Accumulating evidence points to cortical oscillations as a mechanism for mediating interactions among functionally specialized neurons in distributed brain circuits1, 2, 3, 4, 5, 6. A brain function that may use such ...
    • Functional organization of the hippocampal longitudinal axis 

      Strange, B; Witter, Menno; Lein, Ed S.; Moser, Edvard Ingjald (Journal article; Peer reviewed, 2014)
      The precise functional role of the hippocampus remains a topic of much debate. The dominant view is that the dorsal (or posterior) hippocampus is implicated in memory and spatial navigation and the ventral (or anterior) ...
    • Place cells in the hippocampus: Eleven maps for eleven rooms 

      Alme, Charlotte; Miao, Chenglin; Jezek, Karel; Treves, Alessandro; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      The contribution of hippocampal circuits to high-capacity episodic memory is often attributed to the large number of orthogonal activity patterns that may be stored in these networks. Evidence for high-capacity storage in ...
    • Representation of geometric borders in the developing rat 

      Bjerknes, Tale Litlere; Moser, Edvard Ingjald; Moser, May-Britt (Journal article; Peer reviewed, 2014)
      Local space is represented by a number of functionally specific cell types, including place cells in the hippocampus and grid cells, head direction cells, and border cells in the medial entorhinal cortex (MEC). These cells ...
    • Place Cell Rate Remapping by CA3 Recurrent Collaterals 

      Solstad, Trygve; Yousif, HN; Sejnowski, TJ (Journal article; Peer reviewed, 2014)
      Episodic-like memory is thought to be supported by attractor dynamics in the hippocampus. A possible neural substrate for this memory mechanism is rate remapping, in which the spatial map of place cells encodes contextual ...