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Development of the Entorhinal Cortex Occurs via Parallel Lamination During Neurogenesis
(Peer reviewed; Journal article, 2021)The entorhinal cortex (EC) is the spatial processing center of the brain and structurally is an interface between the three layered paleocortex and six layered neocortex, known as the periarchicortex. Limited studies ... -
Exploring the diagnostic potential of adding T2 dependence in diffusion-weighted MR imaging of the prostate
(Peer reviewed; Journal article, 2021)Background: Magnetic resonance imaging (MRI) is essential in the detection and staging of prostate cancer. However, improved tools to distinguish between low-risk and high-risk cancer are needed in order to select the ... -
Experiential seizures related to the hippocampal-parahippocampal spatial representation system
(Peer reviewed; Journal article, 2020)Ictal visual hallucinations may have occipital as well as temporal lobe origin. We report a patient with clustering of focal aware seizures with visual hallucinations. Ictal EEG findings and seizure semiology with alternating ... -
Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy
(Peer reviewed; Journal article, 2021)The entorhinal-hippocampal system contains distinct networks subserving declarative memory. This system is selectively vulnerable to changes of ageing and pathological processes. The entorhinal cortex (EC) is a pivotal ... -
Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
(Peer reviewed; Journal article, 2021)The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a ... -
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium
(Peer reviewed; Journal article, 2020)Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body. ... -
Sex differences in oncogenic mutational processes
(Peer reviewed; Journal article, 2020)Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features ... -
A Machine Learning Approach to Investigate Fronto-Parietal Neural Ensemble Dynamics During Complex
(Chapter, 2020)Brain circuits exhibit very complex dynamics, where individual neurons fire action potentials determining coordinated activity patterns. During behavior, a multitude of brain areas are engaged in planning and execution. A ... -
Perineuronal nets stabilize the grid cell network
(Peer reviewed; Journal article, 2021)Grid cells are part of a widespread network which supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) ... -
Stimulus-specific behavioral responses of zebrafish to a large range of odors exhibit individual variability
(Peer reviewed; Journal article, 2020)Background Odor-driven behaviors such as feeding, mating, and predator avoidance are crucial for animal survival. The neural pathways processing these behaviors have been well characterized in a number of species, and ... -
A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
(Peer reviewed; Journal article, 2020)Locomotion activates an array of sensory inputs that may help build the self-position map of the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to dynamically update representations of the ... -
Densities and numbers of calbindin andparvalbumin positive neurons across the rat and mouse brain
(Peer reviewed; Journal article, 2020)The calcium-binding proteins parvalbumin and calbindin are expressed in neuronal populations regulating brain networks involved in spatial navigation, memory processes, and social interactions. Information about the numbers ... -
The role of hippocampal spatial representations in contextualization and generalization of fear: Fear memory contextualization
(Peer reviewed; Journal article, 2020)Using contextual information to predict aversive events is a critical ability that protects from generalizing fear responses to safe contexts. Animal models have demonstrated the importance of spatial context representations ... -
Studying neuronal circuits during seizure generation
(Doctoral theses at NTNU;2020:279, Doctoral thesis, 2020) -
Developmental mechanisms of spontaneous and sensory evoked activity in the zebrafish habenula
(Doctoral theses at NTNU;2020:306, Doctoral thesis, 2020)Utviklingsmekanismer for spontan- og sensorisk vekket aktivitet i habenula i sebrafisk For å kunne utføre fleksible endringer i vår atferd må vi kunne samle inn og evaluere informasjon som kommer fra både interne kilder ... -
Knowledge Across Reference Frames: Cognitive Maps and Image Spaces
(Peer reviewed; Journal article, 2020)In human and non-human animals, conceptual knowledge is partially organized according to low-dimensional geometries that rely on brain structures and computations involved in spatial representations. Recently, two separate ... -
Allocentric vector coding in the medial entorhinal cortex
(Doctoral theses at NTNU;2020:145, Doctoral thesis, 2020)Samandrag Evna til å dynamisk tolke og navigere omgivnaden er naudsynt for overleving og ligg til grunn for mange kognitive prosessar slik som episodisk minne. I pattedyr-hjernen finn ein spesialiserte nettverk i hippocampus ... -
Functional properties of habenular neurons are determined by developmental stage and sequential neurogenesis
(Peer reviewed; Journal article, 2020)The developing brain undergoes drastic alterations. Here, we investigated developmental changes in the habenula, a brain region that mediates behavioral flexibility during learning, social interactions, and aversive ... -
Behavior-dependent directional tuning in the human visual-navigation network
(Peer reviewed; Journal article, 2020)The brain derives cognitive maps from sensory experience that guide memory formation and behavior. Despite extensive efforts, it still remains unclear how the underlying population activity unfolds during spatial navigation ... -
Associations between the number of children, age at childbirths and prevalence of chronic low back pain: the Nord- Trøndelag Health Study
(Peer reviewed; Journal article, 2020)Background Associations between childbirths and subsequent risk of low back pain (LBP) have not been clarified. Changes in sex hormone levels or lumbar posture during pregnancy may have an impact on LBP later in life. ...
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