Kavliinstitutt for nevrovitenskap
Recent Submissions
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The thalamic midline nucleus reuniens: potential relevance for schizophrenia and epilepsy
(Peer reviewed; Journal article, 2020)In this review we summarize the connectivity of the nucleus reuniens of the thalamus with the hippocampal region and the prefrontal cortex. Using data from animal studies, complemented with sparse data obtained in humans, ... -
An immersive first-person navigation task for abstract knowledge acquisition
(Peer reviewed; Journal article, 2021)Advances in virtual reality (VR) technology have greatly benefited spatial navigation research. By presenting space in a controlled manner, changing aspects of the environment one at a time or manipulating the gain from ... -
Deforming the metric of cognitive maps distorts memory
(Journal article, 2019)Environmental boundaries anchor cognitive maps that support memory. However, trapezoidal boundary geometry distorts the regular firing patterns of entorhinal grid cells, proposedly providing a metric for cognitive maps. ... -
The Hippocampus Maps Concept Space, Not Feature Space
(Peer reviewed; Journal article, 2020)The hippocampal formation encodes maps of space and a key question in neuroscience is whether its spatial coding principles also provide a universal metric for the organization of nonspatial, conceptual information. Previous ... -
Sequence Memory in the Hippocampal–Entorhinal Region
(Peer reviewed; Journal article, 2020)Episodic memories are constructed from sequences of events. When recalling such a memory, we not only recall individual events, but we also retrieve information about how the sequence of events unfolded. Here, we focus on ... -
A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus
(Peer reviewed; Journal article, 2021)Adult neurogenesis in the dentate gyrus plays a role in adaptive brain functions such as memory formation. Adding new neurons to a specific locus of a neural circuit with functional needs is an efficient way to achieve ... -
Development of the Entorhinal Cortex Occurs via Parallel Lamination During Neurogenesis
(Peer reviewed; Journal article, 2021)The entorhinal cortex (EC) is the spatial processing center of the brain and structurally is an interface between the three layered paleocortex and six layered neocortex, known as the periarchicortex. Limited studies ... -
Exploring the diagnostic potential of adding T2 dependence in diffusion-weighted MR imaging of the prostate
(Peer reviewed; Journal article, 2021)Background: Magnetic resonance imaging (MRI) is essential in the detection and staging of prostate cancer. However, improved tools to distinguish between low-risk and high-risk cancer are needed in order to select the ... -
Experiential seizures related to the hippocampal-parahippocampal spatial representation system
(Peer reviewed; Journal article, 2020)Ictal visual hallucinations may have occipital as well as temporal lobe origin. We report a patient with clustering of focal aware seizures with visual hallucinations. Ictal EEG findings and seizure semiology with alternating ... -
Re-emphasizing early Alzheimer's disease pathology starting in select entorhinal neurons, with a special focus on mitophagy
(Peer reviewed; Journal article, 2021)The entorhinal-hippocampal system contains distinct networks subserving declarative memory. This system is selectively vulnerable to changes of ageing and pathological processes. The entorhinal cortex (EC) is a pivotal ... -
Local projections of layer Vb-to-Va are more prominent in lateral than in medial entorhinal cortex
(Peer reviewed; Journal article, 2021)The entorhinal cortex, in particular neurons in layer V, allegedly mediate transfer of information from the hippocampus to the neocortex, underlying long-term memory. Recently, this circuit has been shown to comprise a ... -
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium
(Peer reviewed; Journal article, 2020)Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body. ... -
Sex differences in oncogenic mutational processes
(Peer reviewed; Journal article, 2020)Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features ... -
A Machine Learning Approach to Investigate Fronto-Parietal Neural Ensemble Dynamics During Complex
(Chapter, 2020)Brain circuits exhibit very complex dynamics, where individual neurons fire action potentials determining coordinated activity patterns. During behavior, a multitude of brain areas are engaged in planning and execution. A ... -
Perineuronal nets stabilize the grid cell network
(Peer reviewed; Journal article, 2021)Grid cells are part of a widespread network which supports navigation and spatial memory. Stable grid patterns appear late in development, in concert with extracellular matrix aggregates termed perineuronal nets (PNNs) ... -
Stimulus-specific behavioral responses of zebrafish to a large range of odors exhibit individual variability
(Peer reviewed; Journal article, 2020)Background Odor-driven behaviors such as feeding, mating, and predator avoidance are crucial for animal survival. The neural pathways processing these behaviors have been well characterized in a number of species, and ... -
A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
(Peer reviewed; Journal article, 2020)Locomotion activates an array of sensory inputs that may help build the self-position map of the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to dynamically update representations of the ... -
Densities and numbers of calbindin andparvalbumin positive neurons across the rat and mouse brain
(Peer reviewed; Journal article, 2020)The calcium-binding proteins parvalbumin and calbindin are expressed in neuronal populations regulating brain networks involved in spatial navigation, memory processes, and social interactions. Information about the numbers ... -
The role of hippocampal spatial representations in contextualization and generalization of fear: Fear memory contextualization
(Peer reviewed; Journal article, 2020)Using contextual information to predict aversive events is a critical ability that protects from generalizing fear responses to safe contexts. Animal models have demonstrated the importance of spatial context representations ... -
Studying neuronal circuits during seizure generation
(Doctoral theses at NTNU;2020:279, Doctoral thesis, 2020)
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