Kavliinstitutt for nevrovitenskap
Recent Submissions
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The role of hippocampal spatial representations in contextualization and generalization of fear
(Journal article; Peer reviewed, 2019)Using contextual information to predict aversive events is a critical ability that protects from generalizing fear responses to safe contexts. Animal models have demonstrated the importance of spatial context representations ... -
Neural coding of behavior in the rodent associative cortices
(Doctoral theses at NTNU;2019:357, Doctoral thesis, 2019) -
A Novel Mechanism of Hippocampal Remapping
(Doctoral theses at NTNU;2019:248, Doctoral thesis, 2019) -
Postnatal Development of Functional Projections from Parasubiculum and Presubiculum to Medial Entorhinal Cortex in the Rat
(Journal article; Peer reviewed, 2019)Neurons in parasubiculum (PaS), presubiculum (PrS), and medial entorhinal cortex (MEC) code for place (grid cells) and head direction. Directional input has been shown to be important for stable grid cell properties in ... -
The Hippocampus Encodes Distances in Multidimensional Feature Space
(Journal article; Peer reviewed, 2019)The hippocampal formation encodes maps of the physical environment [1, 2, 3, 4, 5]. A key question in neuroscience is whether its spatial coding principles also provide a universal metric for the organization of non-spatial ... -
Navigating cognition: Spatial codes for human thinking
(Journal article; Peer reviewed, 2018)Ever since Tolman's proposal of cognitive maps in the 1940s, the question of how spatial representations support flexible behavior has been a contentious topic. Bellmund et al. review and combine concepts from cognitive ... -
How the Brain's Navigation System Shapes Our Visual Experience
(Journal article; Peer reviewed, 2018)We explore the environment not only by navigating, but also by viewing our surroundings with our eyes. Here we review growing evidence that the mammalian hippocampal formation, extensively studied in the context of navigation ... -
Hexadirectional Modulation of High-Frequency Electrophysiological Activity in the Human Anterior Medial Temporal Lobe Maps Visual Space
(Journal article; Peer reviewed, 2018)Grid cells are one of the core building blocks of spatial navigation [1]. Single-cell recordings of grid cells in the rodent entorhinal cortex revealed hexagonal coding of the local environment during spatial navigation ... -
Hexadirectional coding of visual space in human entorhinal cortex
(Journal article; Peer reviewed, 2018)Entorhinal grid cells map the local environment, but their involvement beyond spatial navigation remains elusive. We examined human functional MRI responses during a highly controlled visual tracking task and show that ... -
The role of mental maps in decision-making
(Journal article; Peer reviewed, 2017)A growing body of work is investigating the use of mental maps during decision-making. Here we discuss how decision-making organizes experiences according to an internal model of the current task, thereby structuring memory. ... -
Plasticity of hippocampal memories in humans
(Journal article; Peer reviewed, 2017)The human hippocampus is a brain region that supports episodic and spatial memory. Recent experiments have drawn on animal research and computational modelling to reveal how the unique computations and representations of ... -
Mapping sequence structure in the human lateral entorhinal cortex
(Journal article; Peer reviewed, 2019)Remembering event sequences is central to episodic memory and presumably supported by the hippocampal-entorhinal region. We previously demonstrated that the hippocampus maps spatial and temporal distances between events ... -
Hippocampal spike‐time correlations and place field overlaps during open field foraging
(Journal article; Peer reviewed, 2019)Phase precessing place cells encode spatial information on fine timescales via the timing of their spikes. This phase code has been extensively studied on linear tracks and for short runs in the open field. However, less ... -
Neuronal chemo‐architecture of the entorhinal cortex: A comparative review
(Journal article; Peer reviewed, 2019)The identification of neuronal markers, that is, molecules selectively present in subsets of neurons, contributes to our understanding of brain areas and the networks within them. Specifically, recognizing the distribution ... -
Organization of Posterior Parietal–Frontal Connections in the Rat
(Journal article; Peer reviewed, 2019)Recent investigations of the rat posterior parietal cortex (PPC) suggest that this region plays a central role in action control together with the frontal cortical areas. Posterior parietal-frontal cortical connections ... -
Visual and tactile representation of social interactions in mouse secondary motor and anterior cingulate cortices
(Master thesis, 2019)Secondary motor (M2) and anterior cingulate (ACC) cortices are frontal association areas in the rodent brain that receive substantial information from several primary and associative areas, including visual and posterior ... -
Place Cell Rate Remapping by CA3 Recurrent Collaterals
(Journal article; Peer reviewed, 2014)Episodic-like memory is thought to be supported by attractor dynamics in the hippocampus. A possible neural substrate for this memory mechanism is rate remapping, in which the spatial map of place cells encodes contextual ... -
Development and topographical organization of projections from the hippocampus and parahippocampus to the retrosplenial cortex
(Journal article; Peer reviewed, 2019)The rat hippocampal formation (HF), parahippocampal region (PHR), and retrosplenial cortex (RSC) play critical roles in spatial processing. These regions are interconnected, and functionally dependent. The neuronal networks ... -
Convergent projections from perirhinal and postrhinal cortices suggest a multisensory nature of lateral but not medial entorhinal cortex
(Journal article; Peer reviewed, 2019)The current model of the organization of the medial temporal lobe (MTL) episodic memory system assumes that two functionally different “where” and “what” pathways enter MTL as parallel parahippocampal cortex (PHC)-medial ... -
Neurons and networks in the entorhinal cortex: A reappraisal of the lateral and medial entorhinal subdivisions mediating parallel cortical pathways
(Journal article; Peer reviewed, 2019)In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The concept of two entorhinal areas, ...
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