Blar i Institutt for klinisk og molekylær medisin på tidsskrift "Journal of Leukocyte Biology"
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Bacterial secretion systems and regulation of inflammasome activation
(Journal article, 2017)Innate immunity is critical for host defenses against pathogens, but many bacteria display complex ways of interacting with innate immune signaling, as they may both activate and evade certain pathways. Gram‐negative ... -
Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets
(Journal article; Peer reviewed, 2016)The host is protected by pattern recognition systems, including complement and TLRs, which are closely cross-talking. If improperly activated, these systems might induce tissue damage and disease. Inhibition of single ... -
TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies
(Peer reviewed; Journal article, 2020)Inflammation and oxidative stress at the maternal‐fetal interface characterize the placental dysfunction that underlies the pregnancy disorder preeclampsia. Specialized fetal trophoblasts directly interact with leukocytes ... -
TLR8 and complement C5 induce cytokine release and thrombin activation in human whole blood challenged with Gram-positive bacteria
(Journal article; Peer reviewed, 2020)We recently showed that TLR8 is critical for the detection of Gram‐positive bacteria by human monocytes. Here, we hypothesized that TLR8 and complement together regulate antibacterial responses in human blood. Anticoagulated ...