Blar i Institutt for klinisk og molekylær medisin på forfatter "Dale, Ola"
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Cancer pain – clinical studies on prevalence and treatment with nasal fentanyl
Thronæs, Morten (Doctoral thesis at NTNU;2016:81, Doctoral thesis, 2016)Summary in English: Pain is one of the most feared symptoms among cancer patients. Studies show that about 50% of all cancer patients experience pain and these numbers are increasing for patients with advanced disease. ... -
Development and course of chronic pain over 4 years in the general population: The HUNT pain study
Landmark, Tormod; Dale, Ola; Romundstad, Pål Richard; Woodhouse, Astrid; Kaasa, Stein; Borchgrevink, Petter Chr. (Journal article; Peer reviewed, 2018)Background Epidemiological studies of chronic pain frequently report high prevalence estimates. However, there is little information about the development and natural course of chronic pain. Methods We followed a ... -
Development of non-injectable naloxone for pre-hospital reversal of opioid overdoses: A Norwegian project and a review of international status
Glende, Øyvind Danielsson (Master thesis, 2016)Background and aims: Per year, overdoses kill 69.000 users of illicit and prescription opioids in epidemic pattern worldwide. Among them, 250 people in Norway. Naloxone is an effective antidote for opioid overdose reversal, ... -
Innate immune signalling genetics of pain, cognitive dysfunction and sickness symptoms in cancer pain patients treated with transdermal fentanyl
Barratt, Daniel T.; Klepstad, Pål; Dale, Ola; Kaasa, Stein; Somogyi, Andrew A. (Peer reviewed; Journal article, 2015)Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment. Innate immune activation has been implicated ... -
Longitudinal Associations between Exercise and Pain in the General Population - The HUNT Pain Study
Landmark, Tormod; Romundstad, Pål Richard; Borchgrevink, Petter Chr.; Kaasa, Stein; Dale, Ola (Journal article; Peer reviewed, 2013)Background: Population-based studies have reported conflicting findings on the relationship between physical activity and pain, and most studies reporting a relationship are cross sectional. Temporal relationships are ... -
Quantification of doxorubicin in mouse serum and tumor tissue by liquid chromatography tandem mass spectrometry: An application in an in vivo study with murine prostate cancer xenograft tumor and ultrasound-sensitive liposomal doxorubicin
Shrestha, Rinu (Master thesis, 2013)Non-specificity and systemic toxicity are major challenges with cancer chemotherapy. This situation is further complicated by abnormality of tumor microenvironment that presents potential barriers to drug delivery. These ... -
The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses
Skorpen, Frank; von Hofacker, Sebastian; Bjørngaard, Mads; Skogholt, Anne Heidi; Dale, Ola; Kaasa, Stein; Klepstad, Pål (Journal article; Peer reviewed, 2016)BACKGROUND: Genetic variability contributes to variable clinical response to opioids. This study emerged from the observation of three Norwegian patients who showed no or extraordinary poor response to very high doses of ...