• Sensing soluble uric acid by Naip1-Nlrp3 platform 

      Braga, Tarcio Teodoro; Davanso, Mariana Rodrigues; Mendes, Davi; de Souza, Tiago Antonio; de Brito, Anderson Fernandes; Cruz, Mario Costa; Hiyane, Meire Ioshie; de Lima, Dhemerson Souza; Nunes, Vinicius; de Fátima Giarola, Juliana; Souto, Denio Emanuel Pires; Próchnicki, Tomasz; Lauterbach, Mario A.R.; Biscaia, Stellee Marcela Petris; de Freitas, Rilton Alves; Curi, Rui; Pontillo, Alessandra; Latz, Eicke; Camara, Niels Olsen Saraiva (Peer reviewed; Journal article, 2021)
      Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. ...
    • Soluble Uric Acid Activates the NLRP3 Inflammasome 

      Braga, Tarcio Teodoro; Forni, Maria Fernanda; Correa-Costa, Matheus; Ramos, Rodrigo Nalio; Barbuto, Jose Alexandre; Branco, Paola; Castoldi, Angela; Hiyane, Meire Ioshie; Davanso, Mariana Rodrigues; Latz, Eicke; Franklin, Bernardo S.; Kowaltowski, Alicia J.; Camara, Niels Olsen Saraiva (Journal article; Peer reviewed, 2017)
      Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome. Soluble uric acid (sUA) is found in high ...