Blar i Institutt for klinisk og molekylær medisin på tidsskrift "DNA Repair"
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8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
(Journal article; Peer reviewed, 2018)Mitochondrial DNA (mtDNA) resides in close proximity to metabolic reactions, and is maintained by the 8-oxoguanine DNA glycosylase (Ogg1) and other members of the base excision repair pathway. Here, we tested the hypothesis ... -
AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature
(Journal article; Peer reviewed, 2014)tThe most common mutations in cancer are C to T transitions, but their origin has remained elusive.Recently, mutational signatures of APOBEC-family cytosine deaminases were identified in many com-mon cancers, suggesting ... -
Diverse functions of DNA glycosylases processing oxidative base lesions in brain
(Peer reviewed; Journal article, 2019)Endogenous and exogenous oxidative agents continuously damage genomic DNA, with the brain being particularly vulnerable. Thus, preserving genomic integrity is key for brain health and neuronal function. Accumulation of DNA ... -
RNA in DNA repair
(Peer reviewed; Journal article, 2020)Our genome is constantly subject to damage from exogenous and endogenous sources, and cells respond to such damage by initiating a DNA damage response (DDR). Failure to induce an adequate DDR can result in increased mutation ... -
Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53
(Journal article; Peer reviewed, 2019)Non-homologous end joining (NHEJ) is a DNA repair pathway that senses, processes and ligates DNA double-strand breaks (DSBs) throughout the cell cycle. During NHEJ, core Ku70 and Ku80 subunits bind DSBs as a heterodimer ... -
Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70
(Journal article; Peer reviewed, 2017)DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds ...