Blar i Institutt for klinisk og molekylær medisin på tidsskrift "Cancers"
Viser treff 1-19 av 19
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Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions
(Peer reviewed; Journal article, 2021)Lung cancer is the leading cause of cancer-related death worldwide, accounting for nearly one-fifth of all cancer-related deaths. Immunotherapy with immune checkpoint inhibitors has become one of the most promising approaches ... -
Antibiotic Therapy in Integrated Oncology and Palliative Cancer Care: An Observational Study
(Peer reviewed; Journal article, 2022)Simple Summary Approximately one-quarter of the patients with advanced cancer acutely admitted to the Palliative Care Unit at St. Olav’s University Hospital received intravenous antibiotics. We observed that physiological ... -
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma
(Peer reviewed; Journal article, 2022)Cell proliferation requires the orchestrated actions of a myriad of proteins regulating DNA replication, DNA repair and damage tolerance, and cell cycle. Proliferating cell nuclear antigen (PCNA) is a master regulator which ... -
Chemical, Physical and Biological Triggers of Evolutionary Sonserved Bcl-xL-Mediated Apoptosis
(Journal article; Peer reviewed, 2020)Background: The evidence that pan-Bcl-2 or Bcl-xL-specific inhibitors prematurely kill virus-infected or RNA/DNA-transfected cells provides rationale for investigating these apoptotic inducers further. We hypothesized that ... -
A Comparative Analysis of Orthotopic and Subcutaneous Pancreatic Tumour Models: Tumour Microenvironment and Drug Delivery
(Peer reviewed; Journal article, 2023)Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy, mainly due to its resistance to chemotherapy and its complex tumour microenvironment characterised by stromal desmoplasia. There is a need for new ... -
Deterioration in Muscle Mass and Physical Function Differs According to Weight loss History in Cancer Cachexia
(Journal article; Peer reviewed, 2019)Background: Muscle mass and physical function (PF) are common co-primary endpoints in cancer cachexia trials, but there is a lack of data on how these outcomes interact over time. The aim of this secondary analysis of data ... -
Divulging a Pleiotropic Role of Succinate Receptor SUCNR1 in Renal Cell Carcinoma Microenvironment
(Peer reviewed; Journal article, 2022)The succinate receptor, SUCNR1, has been attributed to tumor progression, metastasis, and immune response modulation upon its activation via the oncometabolite succinate. Nonetheless, little is known about the prognostic ... -
Gastric Cancers Missed at Upper Endoscopy in Central Norway 2007 to 2016—a Population-Based Study
(Peer reviewed; Journal article, 2021)Simple summary: Stomach cancer may be missed during upper endoscopy. We have examined how often this occurs and identified factors associated with missed cancers. Among 730 patients with gastric cancer, 67 (9.2%) were ... -
Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System
(Peer reviewed; Journal article, 2021)Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ... -
Nephronectin as a matrix effector in cancer
(Peer reviewed; Journal article, 2021)The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five ... -
The prognostic effect of KRAS mutations in non-small cell lung carcinoma revisited: A norwegian multicentre study
(Peer reviewed; Journal article, 2021)Background: due to emerging therapeutics targeting KRAS G12C and previous reports with conflicting results regarding the prognostic impact of KRAS and KRAS G12C in non-small cell lung cancer (NSCLC), we aimed to investigate ... -
The prognostic value of methylation signatures and NF2 mutations in atypical meningiomas
(Peer reviewed; Journal article, 2021)Background: Due to the solely subjective histopathological assessment, the WHO 2016 classification of human meningiomas is subject to interobserver variation. Consequently, the need for more reliable and objective markers ... -
Quality of life in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy—the randomized nordic9-study
(Peer reviewed; Journal article, 2021)Bowel cancer is one of the leading cancer-types in both sexes worldwide. Despite that most new cases and deaths occur in people aged 70 years or older, few clinical trials have investigated the best way to administer ... -
Response Evaluation after Neoadjuvant Chemotherapy for Resectable Gastric Cancer
(Peer reviewed; Journal article, 2023)Background: The method of response evaluation following neoadjuvant chemotherapy (NAC) in resectable gastric cancer has been widely debated. An essential prerequisite is the ability to stratify patients into subsets of ... -
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis
(Peer reviewed; Journal article, 2020)Extracorporeal photopheresis (ECP), a modality that exposes isolated leukocytes to the photosensitizer 8-methoxypsoralen (8-MOP) and ultraviolet-A (UV-A) light, is used to treat conditions such as cutaneous T-cell lymphoma ... -
Survival and disease recurrence in patients with duodenal neuroendocrine tumours—a single centre cohort
(Journal article; Peer reviewed, 2021)Background: Duodenal neuroendocrine tumours (D-NETs) are rare but increasingly diagnosed. This study aimed to assess the overall survival and recurrence rate among patients treated for D-NETs. Methods: Patients with D-NETs ... -
Survival Trends in Patients with Small Intestinal Neuroendocrine Tumours—A Cohort Study in Central Norway
(Peer reviewed; Journal article, 2023)Improved surgical resection and oncological treatment, or an earlier diagnosis may increase survival in small intestinal neuroendocrine tumours (SI-NETs), but only few studies have examined survival trends. We aimed to ... -
Towards understanding of gastric cancer based upon physiological role of gastrin and ECL cells
(Peer reviewed; Journal article, 2020)The stomach is an ideal organ to study because the gastric juice kills most of the swallowed microbes and, thus, creates rather similar milieu among individuals. Combined with a rather easy access to gastric juice, gastric ... -
Tumor classification should be based on biology and not consensus: Re-defining tumors based on biology may accelerate progress, an experience of gastric cancer
(Journal article; Peer reviewed, 2021)Abstract: Malignant tumors are a consequence of genetic changes mainly occurring during cell division, sometimes with a congenital component. Therefore, accelerated cell divisions will necessarily predispose individuals, ...