Browsing Institutt for klinisk og molekylær medisin by Journals "Cell Reports Medicine"
Now showing items 1-3 of 3
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Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation
(Peer reviewed; Journal article, 2023)During differentiation, neutrophils undergo a spontaneous pro-inflammatory program that is hypothesized here to be under caspase-8 control. In mice, intraperitoneal administration of the caspase-8 inhibitor z-IETD-fmk is ... -
Epitope-resolved profiling of the SARS-CoV-2 antibody response identifies cross-reactivity with endemic human coronaviruses
(Peer reviewed; Journal article, 2021)The SARS-CoV-2 proteome shares regions of conservation with endemic human coronaviruses (CoVs), but it remains unknown to what extent these may be cross-recognized by the antibody response. Here, we study cross-reactivity ... -
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities
(Peer reviewed; Journal article, 2021)Essential E3 ubiquitin ligase HUWE1 (HECT, UBA, and WWE domain containing 1) regulates key factors, such as p53. Although mutations in HUWE1 cause heterogenous neurodevelopmental X-linked intellectual disabilities (XLIDs), ...