Blar i Institutt for klinisk og molekylær medisin på tidsskrift "Scientific Reports"
Viser treff 21-40 av 79
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Explaining sex differences in risk of bloodstream infections using mediation analysis in the population-based HUNT study in Norway
(Peer reviewed; Journal article, 2022)Previous studies indicate sex differences in incidence and severity of bloodstream infections (BSI). We examined the effect of sex on risk of BSI, BSI mortality, and BSI caused by the most common infecting bacteria. Using ... -
The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers
(Peer reviewed; Journal article, 2020)The long non-coding RNA NEAT1 locus is transcribed into two overlapping isoforms, NEAT1_1 and NEAT1_2, of which the latter is essential for the assembly of nuclear paraspeckles. NEAT1 is abnormally expressed in a wide ... -
A fast, low-cost, robust and high-throughput method for viral nucleic acid isolation based on NAxtra magnetic nanoparticles
(Peer reviewed; Journal article, 2023)The year of 2020 was profoundly marked by a global pandemic caused by a strain of coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19). ... -
Ficolins do not alter host immune responses to lipopolysaccharide-induced inflammation in vivo
(Journal article; Peer reviewed, 2017)Ficolins are a family of pattern recognition molecules that are capable of activating the lectin pathway of complement. A limited number of reports have demonstrated a protective role of ficolins in animal models of ... -
Gene expression in blood reflects smoking exposure among cancer-free women in the Norwegian Women and Cancer (NOWAC) postgenome cohort
(Journal article; Peer reviewed, 2021)Active smoking has been linked to modulated gene expression in blood. However, there is a need for a more thorough understanding of how quantitative measures of smoking exposure relate to differentially expressed genes ... -
Genetic risk score associations for myocardial infarction are comparable in persons with and without rheumatoid arthritis: the population-based HUNT study
(Peer reviewed; Journal article, 2020)Persons with rheumatoid arthritis (RA) have increased risk of myocardial infarction (MI). Overlapping associations with MI of weighted genetic risk scores (wGRS) for coronary artery disease (CAD) and RA is unknown in a ... -
Genome-wide microRNA screening in Nile tilapia reveals pervasive isomiRs’ transcription, sex-biased arm switching and increasing complexity of expression throughout development
(Journal article; Peer reviewed, 2018)MicroRNAs (miRNAs) are key regulators of gene expression in multicellular organisms. The elucidation of miRNA function and evolution depends on the identification and characterization of miRNA repertoire of strategic ... -
Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness
(Journal article; Peer reviewed, 2019)Iron is vital for nearly all living organisms, but during infection, not readily available to pathogens. Infectious bacteria therefore depend on specialized mechanisms to survive when iron is limited. These mechanisms make ... -
High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells
(Peer reviewed; Journal article, 2023)Endoglin (ENG) is a single-pass transmembrane protein highly expressed on vascular endothelial cells, although low expression levels can be detected in many other cell types. Its extracellular domain can be found in ... -
High-throughput screening reveals higher synergistic effect of MEK inhibitor combinations in colon cancer spheroids
(Peer reviewed; Journal article, 2020)Drug combinations have been proposed to combat drug resistance, but putative treatments are challenged by low bench-to-bed translational efficiency. To explore the effect of cell culture format and readout methods on ... -
Higher hemoglobin levels are an independent risk factor for gestational diabetes
(Peer reviewed; Journal article, 2022)Incidence of gestational diabetes (GDM) has increased rapidly. It poses significant risks for both mother and fetus affecting also negatively their longer-term metabolic heath. We asked whether early pregnancy maternal ... -
Identification of genetic polymorphisms modulating nausea and vomiting in two series of opioid-treated cancer patients
(Peer reviewed; Journal article, 2020)Nausea and vomiting are often associated with opioid analgesia in cancer patients; however, only a subset of patients develop such side effects. Here, we tested the hypothesis that the occurrence of nausea and vomiting is ... -
Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency
(Journal article; Peer reviewed, 2019)Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients ... -
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
(Journal article; Peer reviewed, 2017)Mutations in the HECT, UBA and WWE domain-containing 1 (HUWE1) E3 ubiquitin ligase cause neurodevelopmental disorder X-linked intellectual disability (XLID). HUWE1 regulates essential processes such as genome integrity ... -
In Vitro and In Vivo Biocompatibility Evaluation of Polyallylamine and Macromolecular Heparin Conjugates Modified Alginate Microbeads
(Journal article; Peer reviewed, 2017)Host reactivity to biocompatible immunoisolation devices is a major challenge for cellular therapies, and a human screening model would be of great value. We designed new types of surface modified barium alginate microspheres, ... -
Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis
(Peer reviewed; Journal article, 2023)Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of ... -
Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19
(Peer reviewed; Journal article, 2020)In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and ... -
Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients
(Journal article; Peer reviewed, 2018)Huntington’s disease (HD) is a progressive neurodegenerative disorder primarily affecting the basal ganglia and is caused by expanded CAG repeats in the huntingtin gene. Except for CAG sizing, mitochondrial and nuclear DNA ... -
Inflammation mediates approximately one quarter of excess relative all-cause mortality in persons with rheumatoid arthritis: the Trøndelag Health Study
(Peer reviewed; Journal article, 2022)Inflammation may contribute to excess mortality in rheumatoid arthritis (RA) patients. We investigated associations to all-cause mortality of the inflammation markers high-sensitivity C-reactive protein (CRP), lactoferrin ... -
Inflammatory markers and risk of cardiovascular mortality in relation to diabetes status in the HUNT study
(Peer reviewed; Journal article, 2021)Inflammatory markers have been associated with increased risk of cardiovascular mortality in general populations. We assessed whether these associations differ by diabetes status. From a population-based cohort study ...