dc.contributor.author | Berg, Kristin Sandal | |
dc.contributor.author | Seines, Ellisiv | |
dc.contributor.author | Gál, Peter | |
dc.contributor.author | Løberg-Emanuelsen, Lise | |
dc.contributor.author | Stubhaug, Audun | |
dc.contributor.author | Nielsen, Erik Waage | |
dc.contributor.author | Spigset, Olav | |
dc.date.accessioned | 2024-05-24T10:57:03Z | |
dc.date.available | 2024-05-24T10:57:03Z | |
dc.date.created | 2024-04-26T09:54:14Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Pharmacology Research & Perspectives. 2024, 12 (2), . | en_US |
dc.identifier.issn | 2052-1707 | |
dc.identifier.uri | https://hdl.handle.net/11250/3131342 | |
dc.description.abstract | No previous studies have investigated the systemic absorption of bupivacaine when used topically for posttonsillectomy pain. The present study was undertaken to investigate the pharmacokinetics of bupivacaine after administration by a swab in the tonsillar fossae over 4 min after tonsillectomy. Eleven adult patients undergoing elective tonsillectomy were recruited. After removal of both tonsils, each of the two tonsillar fossae was covered with a swab moistened with 2 mL of bupivacaine 5 mg/mL, that is, a total of 20 mg bupivacaine. Blood samples were drawn after 0, 5, 10, 20, 30, 45, and 60 min. Bupivacaine was analyzed with an ultra-high-performance liquid chromatography–tandem mass spectrometry method. The highest single measured bupivacaine serum concentration was 23.2 ng/mL and took place 10 min after drug administration. Mean (±SD) Cmax was 11.4 ± 6.0 ng/mL and mean tmax was 11.3 ± 4.7 min. Mean t1/2 was 31.6 ± 9.3 min. As the toxic concentration threshold has been reported to be in the interval 1500–4500 ng/mL, the concentrations measured were well below 2% of the lowest cited toxic threshold. In conclusion, this study shows that applying 4 mL of bupivacaine 5 mg/mL by a swab in the tonsillar fossae posttonsillectomy yields very low plasma concentrations, suggesting its safe application without any risk of systemic toxic effects. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Absorption and pharmacokinetics of bupivacaine after bilateral topical administration in tonsillar fossae for posttonsillectomy pain relief | en_US |
dc.title.alternative | Absorption and pharmacokinetics of bupivacaine after bilateral topical administration in tonsillar fossae for posttonsillectomy pain relief | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 1-5 | en_US |
dc.source.volume | 12 | en_US |
dc.source.journal | Pharmacology Research & Perspectives | en_US |
dc.source.issue | 2 | en_US |
dc.identifier.doi | 10.1002/prp2.1196 | |
dc.identifier.cristin | 2264771 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |