Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
Castela, Inês; Morais, Juliana; Barreiros-Mota, Inês; Silvestre, Marta P.; Marques, Cláudia; Rodrigues, Catarina; Ismael, Shámila; Araújo, João R; Ângelo-Dias, Miguel; Martins, Catarina; Borrego, Luís Miguel; Monteiro, Rosário; dos Santos Ribeiro F. Coutinho, Silvia; Calhau, Conceição; Alho Letra Martins, Catia Patricia; Faria, Ana; Pestana, Diogo; Teixeira, Diana
Journal article, Peer reviewed
Accepted version
Date
2023Metadata
Show full item recordCollections
- Institutt for klinisk og molekylær medisin [3587]
- Publikasjoner fra CRIStin - NTNU [38679]
- St. Olavs hospital [2579]
Original version
American Journal of Physiology. Endocrinology and Metabolism. 2023, 324 (2), E115-E119. 10.1152/ajpendo.00273.2022Abstract
Adiponectin/leptin ratio, triacylglycerols, and waist-to-hip ratio explained almost half of HOMA-IR variance in the context of obesity. This study provides evidence to support adipose tissue dysfunction as a central feature of the pathophysiology of obesity and insulin resistance. Early identification of individuals at higher risk of developing metabolic complications through adipose tissue dysfunction assessment and the staging of obesity and its transient phenotypes can contribute to improve therapeutic decision-making.