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dc.contributor.authorHemminghyth, Mathilde Suhr
dc.contributor.authorChwiszczuk, Luiza
dc.contributor.authorBreitve, Monica Haraldseid
dc.contributor.authorGisladottir, Berglind
dc.contributor.authorGrøntvedt, Gøril Rolfseng
dc.contributor.authorNakling, Arne Exner
dc.contributor.authorRongve, Arvid
dc.contributor.authorFladby, Tormod
dc.contributor.authorKirsebom, Bjørn-Eivind Seljelid
dc.description.abstractMultiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a marker of neuronal body injury) and neurofilament light chain (NfL, a marker of axonal injury) show age-related increases in normal aging. In the current study, we aimed to investigate whether the age-effect within different cognitive domains was mediated by age-associated CSF markers for neurodegenerative changes. We fitted 10 mediation models using structural equation modeling to investigate this in a cohort of 137 healthy adults, aged 40–80 years, from the Norwegian Dementia Disease Initiation (DDI) study. Here, t-tau and NfL were defined as mediators between age and different cognitive tests. The models showed that NfL mediated the age-effect for CERAD learning and memory recall (learning: β = −0.395, p < 0.05; recall: β = −0.261, p < 0.01). No such effect was found in the other models. Our findings suggest that the age-related lower performance in verbal learning and memory may be linked to NfL-associated neurodegenerative changes in cognitively healthy adults.en_US
dc.publisherElsevier B. V.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleCerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adultsen_US
dc.title.alternativeCerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adultsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.source.journalNeurobiology of Agingen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal