dc.contributor.author | Hemminghyth, Mathilde Suhr | |
dc.contributor.author | Chwiszczuk, Luiza | |
dc.contributor.author | Breitve, Monica Haraldseid | |
dc.contributor.author | Gisladottir, Berglind | |
dc.contributor.author | Grøntvedt, Gøril Rolfseng | |
dc.contributor.author | Nakling, Arne Exner | |
dc.contributor.author | Rongve, Arvid | |
dc.contributor.author | Fladby, Tormod | |
dc.contributor.author | Kirsebom, Bjørn-Eivind Seljelid | |
dc.date.accessioned | 2024-03-01T11:57:49Z | |
dc.date.available | 2024-03-01T11:57:49Z | |
dc.date.created | 2024-01-17T16:50:44Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 0197-4580 | |
dc.identifier.uri | https://hdl.handle.net/11250/3120653 | |
dc.description.abstract | Multiple cognitive domains, including learning, memory, and psychomotor speed, show significant reductions with age. Likewise, several cerebrospinal fluid (CSF) neurodegenerative biomarkers, including total tau (t-tau, a marker of neuronal body injury) and neurofilament light chain (NfL, a marker of axonal injury) show age-related increases in normal aging. In the current study, we aimed to investigate whether the age-effect within different cognitive domains was mediated by age-associated CSF markers for neurodegenerative changes. We fitted 10 mediation models using structural equation modeling to investigate this in a cohort of 137 healthy adults, aged 40–80 years, from the Norwegian Dementia Disease Initiation (DDI) study. Here, t-tau and NfL were defined as mediators between age and different cognitive tests. The models showed that NfL mediated the age-effect for CERAD learning and memory recall (learning: β = −0.395, p < 0.05; recall: β = −0.261, p < 0.01). No such effect was found in the other models. Our findings suggest that the age-related lower performance in verbal learning and memory may be linked to NfL-associated neurodegenerative changes in cognitively healthy adults. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier B. V. | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults | en_US |
dc.title.alternative | Cerebrospinal fluid neurofilament light chain mediates age-associated lower learning and memory in healthy adults | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 39-47 | en_US |
dc.source.volume | 135 | en_US |
dc.source.journal | Neurobiology of Aging | en_US |
dc.identifier.doi | 10.1016/j.neurobiolaging.2023.12.005 | |
dc.identifier.cristin | 2228906 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |