dc.contributor.author | Jarholm, Jonas Alexander | |
dc.contributor.author | Bjørnerud, Atle | |
dc.contributor.author | Dalaker, Turi Olene | |
dc.contributor.author | Akhavi, Mehdi Sadat | |
dc.contributor.author | Kirsebom, Bjørn-Eivind | |
dc.contributor.author | Pålhaugen, Lene | |
dc.contributor.author | Nordengen, Kaja | |
dc.contributor.author | Grøntvedt, Gøril Rolfseng | |
dc.contributor.author | Nakling, Arne Exner | |
dc.contributor.author | Kalheim, Lisa Flem | |
dc.contributor.author | Almdahl, Ina Selseth | |
dc.contributor.author | Teceläo, Sandra Raquel Ramos | |
dc.contributor.author | Fladby, Tormod | |
dc.contributor.author | Selnes, Per | |
dc.date.accessioned | 2024-02-20T15:40:36Z | |
dc.date.available | 2024-02-20T15:40:36Z | |
dc.date.created | 2023-08-25T09:24:13Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Journal of Alzheimer's Disease. 2023, 94 (1), 259-279. | en_US |
dc.identifier.issn | 1387-2877 | |
dc.identifier.uri | https://hdl.handle.net/11250/3118748 | |
dc.description.abstract | Background: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer’s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical utility of automated volumetry in a cognitively well-defined and biomarker-classified multi-center longitudinal predementia cohort. Methods: We used Automatic Segmentation of Hippocampal Subfields (ASHS) to determine MTL morphometry from MRI. We harmonized scanner effects using the recently developed longitudinal ComBat. Subjects were classified according to the A/T/N system, and as normal controls (NC), subjective cognitive decline (SCD), or mild cognitive impairment (MCI). Positive or negative values of A, T, and N were determined by cerebrospinal fluid measurements of the Aβ42/40 ratio, phosphorylated and total tau. From 406 included subjects, longitudinal data was available for 206 subjects by stage, and 212 subjects by A/T/N. Results: Compared to A–/T–/N– at baseline, the entorhinal cortex, anterior and posterior hippocampus were smaller in A+/T+orN+. Compared to NC A– at baseline, these subregions were also smaller in MCI A+. Longitudinally, SCD A+ and MCI A+, and A+/T–/N– and A+/T+orN+, had significantly greater atrophy compared to controls in both anterior and posterior hippocampus. In the entorhinal and parahippocampal cortices, longitudinal atrophy was observed only in MCI A+ compared to NC A–, and in A+/T–/N– and A+/T+orN+ compared to A–/T–/N–. Conclusion: We found MTL neurodegeneration largely consistent with existing models, suggesting that harmonized MRI volumetry may be used under conditions that are common in clinical multi-center cohorts. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | IOS Press | en_US |
dc.rights | Navngivelse-Ikkekommersiell 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/deed.no | * |
dc.title | Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort | en_US |
dc.title.alternative | Medial Temporal Lobe Atrophy in Predementia Alzheimer's Disease: A Longitudinal Multi-Site Study Comparing Staging and A/T/N in a Clinical Research Cohort | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 259-279 | en_US |
dc.source.volume | 94 | en_US |
dc.source.journal | Journal of Alzheimer's Disease | en_US |
dc.source.issue | 1 | en_US |
dc.identifier.doi | 10.3233/JAD-221274 | |
dc.identifier.cristin | 2169519 | |
dc.relation.project | Norges forskningsråd: 333157 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |