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dc.contributor.authorHowe, Laurence J.
dc.contributor.authorBrumpton, Ben Michael
dc.contributor.authorRasheed, Humaira
dc.contributor.authorÅsvold, Bjørn Olav
dc.contributor.authorDavey Smith, George
dc.contributor.authorDavies, Neil Martin
dc.date.accessioned2023-03-06T12:30:23Z
dc.date.available2023-03-06T12:30:23Z
dc.date.created2022-05-03T17:12:38Z
dc.date.issued2022
dc.identifier.citationeLIFE. 2022, 11 e72984.en_US
dc.identifier.issn2050-084X
dc.identifier.urihttps://hdl.handle.net/11250/3056045
dc.description.abstractBackground: Taller people have a lower risk of coronary heart disease but a higher risk of many cancers. Mendelian randomization (MR) studies in unrelated individuals (population MR) have suggested that these relationships are potentially causal. However, population MR studies are sensitive to demography (population stratification, assortative mating) and familial (indirect genetic) effects. Methods: In this study, we performed within-sibship MR analyses using 78,988 siblings, a design robust against demography and indirect genetic effects of parents. For comparison, we also applied population MR and estimated associations with measured height. Results: Within-sibship MR estimated that 1 SD taller height lowers the odds of coronary heart disease by 14% (95% CI: 3–23%) but increases the odds of cancer by 18% (95% CI: 3–34%), highly consistent with population MR and height-disease association estimates. There was some evidence that taller height reduces systolic blood pressure and low-density lipoprotein cholesterol, which may mediate some of the protective effects of taller height on coronary heart disease risk. Conclusions: For the first time, we have demonstrated that the purported effects of height on adulthood disease risk are unlikely to be explained by demographic or familial factors, and so likely reflect an individual-level causal effect. Disentangling the mechanisms via which height affects disease risk may improve the understanding of the etiologies of atherosclerosis and carcinogenesis. Funding: This project was conducted by researchers at the MRC Integrative Epidemiology Unit (MC_UU_00011/1) and also supported by a Norwegian Research Council Grant number 295989.en_US
dc.language.isoengen_US
dc.publishereLifeen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectGenetisk epidemiologien_US
dc.subjectGenetic Epidemiologyen_US
dc.subjectEpidemiologi medisinsken_US
dc.subjectEpidemiologyen_US
dc.titleTaller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization studyen_US
dc.title.alternativeTaller height and risk of coronary heart disease and cancer: A within-sibship Mendelian randomization studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.subject.nsiVDP::Medisinske fag: 700en_US
dc.subject.nsiVDP::Midical sciences: 700en_US
dc.source.pagenumbere72984-?en_US
dc.source.volume11en_US
dc.source.journaleLIFEen_US
dc.identifier.doi10.7554/eLife.72984
dc.identifier.cristin2021165
dc.relation.projectNorges forskningsråd: 295989en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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