Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, Stavroula; Graham, Sarah E.; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; Zhu, Xiang; Clarke, Shoa L.; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J M; Wu, Kuan-Han H; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chikashi; Kanai, Masahiro; Zhou, Wei; Brumpton, Ben Michael; Rasheed, Humaira; Havulinna, Aki S.; Veturi, Yogasudha; Pacheco, Jennifer Allen; Rosenthal, Elisabeth A.; Lingren, Todd; Feng, QiPing; Kullo, Iftikhar J.; Narita, Akira; Takayama, Jun; Martin, Hilary C.; Hunt, Karen A.; Trivedi, Bhavi; Haessler, Jeffrey; Giulianini, Franco; Bradford, Yuki; Miller, Jason E.; Campbell, Archie; Lin, Kuang; Millwood, Iona Y.; Rasheed, Asif; Hindy, George; Faul, Jessica D.; Zhao, Wei; Weir, David R.; Turman, Constance; Huang, Hongyan; Graff, Mariaelisa; Choudhury, Ananyo; Sengupta, Dhriti; Mahajan, Anubha; Brown, Michael R.; Zhang, Weihua; Yu, Ketian; Schmidt, Ellen M.; Pandit, Anita; Gustafsson, Stefan; Yin, Xianyong; Luan, Jian'an; Zhao, Jing-Hua; Matsuda, Fumihiko; Jang, Hye-Mi; Yoon, Kyungheon; Medina-Gomez, Carolina; Pitsillides, Achilleas; Hottenga, Jouke Jan; Wood, Andrew R.; Ji, Yingji; Gao, Zishan; Haworth, Simon; Yousri, Noha A.; Mitchell, Ruth E.; Chai, Jin Fang; Aadahl, Mette; Bjerregaard, Anne A.; Yao, Jie; Manichaikul, Ani; Hwu, Chii-Min; Hung, Yi-Jen; Warren, Helen R.; Ramirez, Julia; Bork-Jensen, Jette; Kårhus, Line L.; Goel, Anuj; Sabater-Lleal, Maria; Noordam, Raymond; Mauro, Pala; Matteo, Floris; McDaid, Aaron F.; Marques-Vidal, Pedro; Wielscher, Matthias; Trompet, Stella; Sattar, Naveed; Møllehave, Line T.; Munz, Matthias; Zeng, Lingyao; Huang, Jianfeng; Yang, Bin; Poveda, Alaitz; Kurbasic, Azra; Lamina, Claudia; Forer, Lukas; Scholz, Markus; Galesloot, Tessel E.; Bradfield, Jonathan P.; Ruotsalainen, Sanni E.; Daw, EWarwick; Zmuda, Joseph M.; Mitchell, Jonathan S.; Fuchsberger, Christian; Christensen, Henry; Brody, Jennifer A.; Vazquez-Moreno, Miguel; Feitosa, Mary F.; Wojczynski, Mary K.; Wang, Zhe; Preuss, Michael H.; Mangino, Massimo; Christofidou, Paraskevi; Verweij, Niek; Benjamins, Jan W.; Engmann, Jorgen; Tsao, Noah L.; Verma, Anurag; Slieker, Roderick C.; Lo, Ken Sin; Zilhao, Nuno R.; Le, Phuong; Kleber, Marcus E.; Delgado, Graciela E.; Huo, Shaofeng; Ikeda, Daisuke D.; Iha, Hiroyuki; Yang, Jian; Liu, Jun; Demirkan, Ayşe; Leonard, Hampton L.; Marten, Jonathan; Frank, Mirjam; Schmidt, Börge; Smyth, Laura J.; Cañadas-Garre, Marisa; Wang, Chaolong; Nakatochi, Masahiro; Wong, Andrew; Hutri-Kähönen, Nina; Sim, Xueling; Xia, Rui; Huerta-Chagoya, Alicia; Fernandez-Lopez, Juan Carlos; Lyssenko, Valeriya; Nongmaithem, Suraj S.; Bayyana, Swati; Stringham, Heather M.; Irvin, Marguerite R.; Oldmeadow, Christopher; Kim, Han-Na; Ryu, Seungho; Timmers, Paul R H J; Arbeeva, Liubov; Dorajoo, Rajkumar; Lange, Leslie A.; Prasad, Gauri; Lorés-Motta, Laura; Pauper, Marc; Long, Jirong; Li, Xiaohui; Theusch, Elizabeth; Takeuchi, Fumihiko; Spracklen, Cassandra N.; Loukola, Anu; Bollepalli, Sailalitha; Warner, Sophie C.; Wang, Ya Xing; Wei, Wen B.; Nutile, Teresa; Ruggiero, Daniela; Sung, Yun Ju; Chen, Shufeng; Liu, Fangchao; Yang, Jingyun; Kentistou, Katherine A.; Banas, Bernhard; Nardone, Giuseppe Giovanni; Meidtner, Karina; Bielak, Lawrence F.; Smith, Jennifer A.; Hebbar, Prashantha; Farmaki, Aliki-Eleni; Hofer, Edith; Lin, Maoxuan; Concas, Maria Pina; Vaccargiu, Simona; van der Most, Peter J.; Pitkänen, Niina; Cade, Brian E.; van der Laan, Sander W.; Chitrala, Kumaraswamy Naidu; Weiss, Stefan; Bentley, Amy R.; Doumatey, Ayo P.; Adeyemo, Adebowale A.; Lee, Jong Young; Petersen, Eva R B; Nielsen, Aneta A.; Choi, Hyeok Sun; Nethander, Maria; Freitag-Wolf, Sandra; Southam, Lorraine; Rayner, Nigel W.; Wang, Carol A.; Lin, Shih-Yi; Wang, Jun-Sing; Couture, Christian; Lyytikäinen, Leo-Pekka; Nikus, Kjell; Cuellar-Partida, Gabriel; Vestergaard, Henrik; Hidalgo, Bertha; Giannakopoulou, Olga; Cai, Qiuyin; Obura, Morgan O.; van Setten, Jessica; Li, Xiaoyin; Liang, Jingjing; Tang, Hua; Terzikhan, Natalie; Shin, Jae Hun; Jackson, Rebecca D.; Reiner, Alexander P.; Martin, Lisa Warsinger; Chen, Zhengming; Li, Liming; Kawaguchi, Takahisa; Thiery, Joachim; Bis, Joshua C.; Launer, Lenore J.; Li, Huaixing; Nalls, Mike A.; Raitakari, Olli T.; Ichihara, Sahoko; Wild, Sarah H.; Nelson, Christopher P.; Campbell, Harry; Jäger, Susanne; Nabika, Toru; Al-Mulla, Fahd; Niinikoski, Harri; Braund, Peter S.; Kolcic, Ivana; Kovacs, Peter; Giardoglou, Tota; Katsuya, Tomohiro; de Kleijn, Dominique; de Borst, Gert J.; Kim, Eung Kweon; Adams, Hieab H H; Ikram, M Arfan; Zhu, Xiaofeng; Asselbergs, Folkert W.; Kraaijeveld, Adriaan O.; Beulens, Joline W J; Shu, Xiao-Ou; Rallidis, Loukianos S.; Pedersen, Oluf; Hansen, Torben; Mitchell, Paul; Hewitt, Alex W.; Kähönen, Mika; Pérusse, Louis; Bouchard, Claude; Tönjes, Anke; Chen, Yii-Der Ida; Pennell, Craig E.; Mori, Trevor A.; Lieb, Wolfgang; Franke, Andre; Ohlsson, Claes; Mellström, Dan; Cho, Yoon Shin; Lee, Hyejin; Yuan, Jian-Min; Koh, Woon-Puay; Rhee, Sang Youl; Woo, Jeong-Taek; Heid, Iris M.; Stark, Klaus J.; Zimmermann, Martina E.; Völzke, Henry; Homuth, Georg; Evans, Michele K.; Zonderman, Alan B.; Polasek, Ozren; Pasterkamp, Gerard; Hoefer, Imo E.; Redline, Susan; Pahkala, Katja; Oldehinkel, Albertine J.; Snieder, Harold; Biino, Ginevra; Schmidt, Reinhold; Schmidt, Helena; Bandinelli, Stefania; Dedoussis, George; Thanaraj, Thangavel Alphonse; Kardia, Sharon L R; Peyser, Patricia A.; Kato, Norihiro; Schulze, Matthias B.; Girotto, Giorgia; Böger, Carsten A.; Jung, Bettina; Joshi, Peter K.; Bennett, David A.; De Jager, Philip L.; Lu, Xiangfeng; Mamakou, Vasiliki; Brown, Morris; Caulfield, Mark J.; Munroe, Patricia B.; Guo, Xiuqing; Ciullo, Marina; Jonas, Jost B.; Samani, Nilesh J.; Kaprio, Jaakko; Pajukanta, Päivi; Tusié-Luna, Teresa; Aguilar-Salinas, Carlos A.; Adair, Linda S.; Bechayda, Sonny Augustin; de Silva, H Janaka; Wickremasinghe, Ananda R.; Krauss, Ronald M.; Wu, Jer-Yuarn; Zheng, Wei; Hollander, Anneke Iden; Bharadwaj, Dwaipayan; Correa, Adolfo; Wilson, James G.; Lind, Lars; Heng, Chew-Kiat; Nelson, Amanda E.; Golightly, Yvonne M.; Wilson, James F.; Penninx, Brenda; Kim, Hyung-Lae; Attia, John; Scott, Rodney J.; Rao, D.C.; Arnett, Donna K.; Hunt, Steven C.; Walker, Mark; Koistinen, Heikki A.; Chandak, Giriraj R.; Mercader, Josep M.; Costanzo, Maria C.; Jang, Dongkeun; Burtt, Noël P; Villalpando, Clicerio Gonzalez; Orozco, Lorena; Fornage, Myriam; Tai, EShyong; van Dam, Rob M.; Lehtimäki, Terho; Chaturvedi, Nish; Yokota, Mitsuhiro; Liu, Jianjun; Reilly, Dermot F.; McKnight, Amy Jayne; Kee, Frank; Jöckel, Karl-Heinz; McCarthy, Mark I.; Palmer, Colin N A; Vitart, Veronique; Hayward, Caroline; Simonsick, Eleanor; van Duijn, Cornelia M.; Jin, Zi-Bing; Qu, Jia; Hishigaki, Haretsugu; Lin, Xu; März, Winfried; Gudnason, Vilmundur; Tardif, Jean-Claude; Lettre, Guillaume; Hart, Leen M 't; Elders, Petra J M; Damrauer, Scott M.; Kumari, Meena; Kivimaki, Mika; van der Harst, Pim; Spector, Tim D.; Loos, Ruth J F; Province, Michael A.; Parra, Esteban J.; Cruz, Miguel; Psaty, Bruce M.; Brandslund, Ivan; Pramstaller, Peter P.; Rotimi, Charles N.; Christensen, Kaare; Ripatti, Samuli; Widén, Elisabeth; Hakonarson, Hakon; Grant, Struan F A; Kiemeney, Lambertus A L M; de Graaf, Jacqueline; Loeffler, Markus; Kronenberg, Florian; Gu, Dongfeng; Erdmann, Jeanette; Schunkert, Heribert; Franks, Paul W.; Linneberg, Allan; Jukema, J Wouter; Khera, Amit V.; Männikkö, Minna; Jarvelin, Marjo-Riitta; Kutalik, Zoltan; Francesco, Cucca; Mook-Kanamori, Dennis O.; van Dijk, Ko Willems; Watkins, Hugh; Strachan, David P.; Grarup, Niels; Sever, Peter; Poulter, Neil; Chuang, Lee-Ming; Rotter, Jerome I.; Dantoft, Thomas M.; Karpe, Fredrik; Neville, Matt J.; Timpson, Nicholas J.; Cheng, Ching-Yu; Wong, Tien-Yin; Khor, Chiea Chuen; Li, Hengtong; Sabanayagam, Charumathi; Peters, Annette; Gieger, Christian; Hattersley, Andrew T.; Pedersen, Nancy L.; Magnusson, Patrik K E; Boomsma, Dorret I.; Willemsen, Allegonda H M; Cupples, LAdrienne; van Meurs, Joyce B J; Ghanbari, Mohsen; Gordon-Larsen, Penny; Huang, Wei; Kim, Young Jin; Tabara, Yasuharu; Wareham, Nicholas J.; Langenberg, Claudia; Zeggini, Eleftheria; Kuusisto, Johanna; Laakso, Markku; Ingelsson, Erik; Abecasis, Goncalo; Chambers, John C.; Kooner, Jaspal S.; de Vries, Paul S.; Morrison, Alanna C.; Hazelhurst, Scott; Ramsay, Michèle; North, Kari E.; Daviglus, Martha; Kraft, Peter; Martin, Nicholas G.; Whitfield, John B.; Abbas, Shahid; Saleheen, Danish; Walters, Robin G.; Holmes, Michael V.; Black, Corri; Smith, Blair H.; Baras, Aris; Justice, Anne E.; Buring, Julie E.; Ridker, Paul M.; Chasman, Daniel I.; Kooperberg, Charles; Tamiya, Gen; Yamamoto, Masayuki; van Heel, David A.; Trembath, Richard C.; Wei, Wei-Qi; Jarvik, Gail P.; Namjou, Bahram; Hayes, M Geoffrey; Ritchie, Marylyn D.; Jousilahti, Pekka; Salomaa, Veikko; Hveem, Kristian; Åsvold, Bjørn Olav; Kubo, Michiaki; Kamatani, Yoichiro; Okada, Yukinori; Murakami, Yoshinori; Kim, Bong-Jo; Thorsteinsdottir, Unnur; Stefansson, Kari; Zhang, Jifeng; Chen, YEugene; Ho, Yuk-Lam; Lynch, Julie A.; Rader, Daniel J.; Tsao, Philip S.; Chang, Kyong-Mi; Cho, Kelly; O'Donnell, Christopher J.; Gaziano, John M.; Wilson, Peter W F; Frayling, Timothy M.; Hirschhorn, Joel N.; Kathiresan, Sekar; Mohlke, Karen L.; Sun, Yan V.; Morris, Andrew P.; Boehnke, Michael; Brown, Christopher D.; Natarajan, Pradeep; Deloukas, Panos; Willer, Cristen J.; Assimes, Themistocles L.; Peloso, Gina M.
Peer reviewed, Journal article
Published version
Permanent lenke
https://hdl.handle.net/11250/3051754Utgivelsesdato
2022Metadata
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Sammendrag
Background
Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.
Results
To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.
Conclusions
Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
Utgiver
BMCTidsskrift
Genome BiologyBeslektede innførsler
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E.; Marcus, Gregory M.; Vidal, Pedro Marques; Martin, Nicholas G.; März, Winfried; Matsuda, Fumihiko; McGarrah, Robert W.; McGue, Matt; McKnight, Amy Jayne; Medland, Sarah E.; Mellström, Dan; Metspalu, Andres; Mitchell, Braxton D.; Mitchell, Paul; Mook-Kanamori, Dennis O.; Morris, Andrew D.; Mucci, Lorelei A.; Munroe, Patricia B.; Nalls, Mike A.; Nazarian, Saman; Nelson, Amanda E.; Neville, Matt J.; Newton-Cheh, Christopher; Nielsen, Christopher Sivert; Nöthen, Markus M.; Ohlsson, Claes; Oldehinkel, Albertine J.; Orozco, Lorena; Pahkala, Katja; Pajukanta, Päivi; Palmer, Colin N. A.; Parra, Esteban J.; Pattaro, Cristian; Pedersen, Oluf; Pennell, Craig E.; Penninx, Brenda W. J. 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Y.; O’Donnell, Christopher J.; Rivadeneira, Fernando; Thorsteinsdottir, Unnur; Sun, Yan V.; Tai, E. Shyong; Boehnke, Michael; Deloukas, Panos; Justice, Anne E.; Lindgren, Cecilia M.; Loos, Ruth J. F.; Mohlke, Karen L.; North, Kari E.; Stefansson, Kari; Walters, Robin G.; Winkler, Thomas W.; Young, Kristin L.; Loh, Po-Ru; Yang, Jian; Esko, Tõnu; Assimes, Themistocles L.; Auton, Adam; Abecasis, Goncalo R.; Willer, Cristen J.; Locke, Adam E.; Berndt, Sonja I.; Lettre, Guillaume; Frayling, Timothy M.; Okada, Yukinori; Wood, Andrew R.; Visscher, Peter M.; Hirschhorn, Joel N. (Peer reviewed; Journal article, 2022)Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40–50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. ... -
Diminishing benefits of urban living for children and adolescents’ growth and development
Mishra, Anu; Zhou, Bin; Rodriguez-Martinez, Andrea; Bixby, Honor; Singleton, Rosie K.; Carrillo-Larco, Rodrigo M.; Sheffer, Kate E.; Paciorek, Christopher J.; Bennett, James E.; Lhoste, Victor; Iurilli, Maria L. 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L.; Kiechl-Kohlendorfer, Ursula; Kiechl, Sophia J.; Kiechl, Stefan; Killewo, Japhet; Kim, Hyeon Chang; Kim, Jeongseon; Kindblom, Jenny M.; Kingston, Andrew; Klakk, Heidi; Klimek, Magdalena; Klimont, Jeannette; Klumbiene, Jurate; Knoflach, Michael; Koirala, Bhawesh; Kolle, Elin; Kolsteren, Patrick; König, Jürgen; Korpelainen, Raija; Korrovits, Paul; Korzycka, Magdalena; Kos, Jelena; Koskinen, Seppo; Kouda, Katsuyasu; Kovács, Éva; Kovacs, Viktoria Anna; Kovalskys, Irina; Kowlessur, Sudhir; Koziel, Slawomir; Kratenova, Jana; Kratzer, Wolfgang; Kriaucioniene, Vilma; Kriemler, Susi; Kristensen, Peter Lund; Krizan, Helena; Kroker-Lobos, Maria F.; Krokstad, Steinar; Kromhout, Daan; Kruger, Herculina S.; Kruger, Ruan; Kryst, Łukasz; Kubinova, Ruzena; Kuciene, Renata; Kujala, Urho M.; Kujundzic, Enisa; Kulaga, Zbigniew; Kulimbet, Mukhtar; Kumar, R. Krishna; Kunešová, Marie; Kurjata, Pawel; Kusuma, Yadlapalli S.; Kutsenko, Vladimir; Kuulasmaa, Kari; Kyobutungi, Catherine; La, Quang Ngoc; Laamiri, Fatima Zahra; Lachat, Carl; Lackner, Karl J.; Laid, Youcef; Lall, Lachmie; Lam, Tai Hing; Jimenez, Maritza Landaeta; Landais, Edwige; Lanska, Vera; Lappas, Georg; Larijani, Bagher; Larissa, Simo Pone; Latt, Tint Swe; Laurenzi, Martino; Lauria, Laura; Lazo-Porras, Maria; Le Coroller, Gwenaëlle; Le Nguyen Bao, Khanh; Le Port, Agnès; Le, Tuyen D.; Lee, Jeannette; Lee, Jeonghee; Lee, Paul H.; Lehmann, Nils; Lehtimäki, Terho; Lemogoum, Daniel; Leskošek, Branimir; Leszczak, Justyna; Leth-Møller, Katja B.; Leung, Gabriel M.; Levitt, Naomi S.; Li, Yanping; Liivak, Merike; Lilly, Christa L.; Lim, Charlie; Lim, Wei-Yen; Lima-Costa, M. Fernanda; Lin, Hsien-Ho; Lin, Xu; Lin, Yi-Ting; Lind, Lars; Lingam, Vijaya; Linkohr, Birgit; Linneberg, Allan; Lissner, Lauren; Litwin, Mieczyslaw; Liu, Jing; Liu, Lijuan; Lo, Wei-Cheng; Loit, Helle-Mai; Long, Khuong Quynh; Abril, Guadalupe Longo; Lopes, Luis; Lopes, Marcus V. V.; Lopes, Oscar; Lopez-Garcia, Esther; Lopez, Tania; Lotufo, Paulo A.; Lozano, José Eugenio; Lukrafka, Janice L.; Luksiene, Dalia; Lundqvist, Annamari; Lunet, Nuno; Lunogelo, Charles; Lustigová, Michala; Łuszczki, Edyta; M’Buyamba-Kabangu, Jean-René; Ma, Guansheng; Ma, Xu; Machado-Coelho, George L. L.; Machado-Rodrigues, Aristides M.; Macia, Enguerran; Macieira, Luisa M.; Madar, Ahmed Ali; Madsen, Anja L.; Maestre, Gladys E.; Maggi, Stefania; Magliano, Dianna J.; Magnacca, Sara; Magriplis, Emmanuella; Mahasampath, Gowri; Maire, Bernard; Majer, Marjeta; Makdisse, Marcia; Mäki, Päivi; Malekzadeh, Fatemeh; Malekzadeh, Reza; Malhotra, Rahul; Rao, Kodavanti Mallikharjuna; Malyutina, Sofia K.; Maniego, Lynell V.; Manios, Yannis; Manix, Masimango Imani; Mann, Jim I.; Mansour-Ghanaei, Fariborz; Manyanga, Taru; Manzato, Enzo; Marcil, Anie; Margozzini, Paula; Mariño, Joany; Markaki, Anastasia; Markey, Oonagh; Ioannidou, Eliza Markidou; Marques-Vidal, Pedro; Marques, Larissa Pruner; Marrugat, Jaume; Martin-Prevel, Yves; Martin, Rosemarie; Martorell, Reynaldo; Martos, Eva; Maruszczak, Katharina; Marventano, Stefano; Masala, Giovanna; Mascarenhas, Luis P.; Masoodi, Shariq R.; Mathiesen, Ellisiv B.; Mathur, Prashant; Matijasevich, Alicia; Matłosz, Piotr; Matsha, Tandi E.; Matsudo, Victor; Mavrogianni, Christina; Mazur, Artur; Mbanya, Jean Claude N.; McFarlane, Shelly R.; McGarvey, Stephen T.; McKee, Martin; McLachlan, Stela; McLean, Rachael M.; McLean, Scott B.; McNairy, Margaret L.; McNulty, Breige A.; Benchekor, Sounnia Mediene; Medzioniene, Jurate; Mehdipour, Parinaz; Mehlig, Kirsten; Mehrparvar, Amir Houshang; Meirhaeghe, Aline; Meisfjord, Jørgen Rajan; Meisinger, Christa; Melgarejo, Jesus D.; Melkumova, Marina; Mello, João; Méndez, Fabián; Mendivil, Carlos O.; Menezes, Ana Maria B.; Menon, Geetha R.; Mensink, Gert B. M.; Menzano, Maria Teresa; Meshram, Indrapal I.; Meto, Diane T.; Mi, Jie; Michaelsen, Kim F.; Michels, Nathalie; Mikkel, Kairit; Miłkowska, Karolina; Miller, Jody C.; Milushkina, Olga; Minderico, Cláudia S.; Mini, G.K.; Miquel, Juan Francisco; Miranda, J. Jaime; Mirjalili, Mohammad Reza; Mirkopoulou, Daphne; Mirrakhimov, Erkin; Mišigoj-Duraković, Marjeta; Mistretta, Antonio; Mocanu, Veronica; Modesti, Pietro A.; Moghaddam, Sahar Saeedi; Mohajer, Bahram; Mohamed, Mostafa K.; Mohamed, Shukri F.; Mohammad, Kazem; Mohammadi, Mohammad Reza; Mohammadi, Zahra; Mohammadifard, Noushin; Mohammadpourhodki, Reza; Mohan, Viswanathan; Mohanna, Salim; Yusoff, Muhammad Fadhli Mohd; Mohebbi, Iraj; Mohebi, Farnam; Moitry, Marie; Møllehave, Line T.; Møller, Niels C.; Molnár, Dénes; Momenan, Amirabbas; Mondo, Charles K.; Montenegro Mendoza, Roger A.; Monterrubio-Flores, Eric; Monyeki, Kotsedi Daniel K.; Moon, Jin Soo; Moosazadeh, Mahmood; Mopa, Hermine T.; Moradpour, Farhad; Moreira, Leila B.; Morejon, Alain; Moreno, Luis A.; Morey, Francis; Morgan, Karen; Morin, Suzanne N.; Mortensen, Erik Lykke; Moschonis, George; Moslem, Alireza; Mossakowska, Malgorzata; Mostafa, Aya; Mostafavi, Seyed-Ali; Mota-Pinto, Anabela; Mota, Jorge; Motlagh, Mohammad Esmaeel; Motta, Jorge; Moura-dos-Santos, Marcos André; Movsesyan, Yeva; Msyamboza, Kelias P.; Mu, Thet Thet; Muc, Magdalena; Muca, Florian; Mugoša, Boban; Muiesan, Maria L.; Müller-Nurasyid, Martina; Münzel, Thomas; Mursu, Jaakko; Murtagh, Elaine M.; Musa, Kamarul Imran; Milanović, Sanja Musić; Musil, Vera; Musinguzi, Geofrey; Muyer, Muel Telo M. C.; Nabipour, Iraj; Naderimagham, Shohreh; Nagel, Gabriele; Najafi, Farid; Nakamura, Harunobu; Nalecz, Hanna; Námešná, Jana; Nang, Ei Ei K.; Nangia, Vinay B.; Nankap, Martin; Narake, Sameer; Nardone, Paola; Naseri, Take; Nauck, Matthias; Neal, William A.; Nejatizadeh, Azim; Nekkantti, Chandini; Nelis, Keiu; Nenko, Ilona; Neovius, Martin; Nervi, Flavio; Ng, Tze Pin; Nguyen, Chung T.; Nguyen, Nguyen D.; Nguyen, Quang Ngoc; Ni, Michael Y.; Nicolescu, Rodica; Nie, Peng; Nieto-Martínez, Ramfis E.; Nikitin, Yury P.; Ning, Guang; Ninomiya, Toshiharu; Nishi, Nobuo; Nishtar, Sania; Noale, Marianna; Noboa, Oscar A.; Nogueira, Helena; Nordendahl, Maria; Nordestgaard, Børge G.; Noto, Davide; Nowak-Szczepanska, Natalia; Nsour, Mohannad Al; Nuhoğlu, Irfan; Nunes, Baltazar; Nurk, Eha; Nuwaha, Fred; Nyirenda, Moffat; O’Neill, Terence W.; O’Reilly, Dermot; Obreja, Galina; Ochimana, Caleb; Ochoa-Avilés, Angélica M.; Oda, Eiji; Odili, Augustine N.; Oh, Kyungwon; Ohara, Kumiko; Ohlsson, Claes; Ohtsuka, Ryutaro; Olafsson, Örn; Olinto, Maria Teresa A.; Oliveira, Isabel O.; Omar, Mohd Azahadi; Omar, Saeed M.; Onat, Altan; Ong, Sok King; Onland-Moret, N. Charlotte; Ono, Lariane M.; Ordunez, Pedro; Ornelas, Rui; Ortiz, Ana P.; Ortiz, Pedro J.; Osler, Merete; Osmond, Clive; Ostojic, Sergej; Ostovar, Afshin; Otero, Johanna A.; Overvad, Kim; Owusu-Dabo, Ellis; Paccaud, Fred Michel; Pagkalos, Ioannis; Pahomova, Elena; de Paiva, Karina Mary; Pająk, Andrzej; Palloni, Alberto; Palmieri, Luigi; Pan, Wen-Harn; Panda-Jonas, Songhomitra; Pandey, Arvind; Panza, Francesco; Paoli, Mariela; Papadopoulou, Sousana K.; Papandreou, Dimitrios; Pareja, Rossina G.; Park, Soon-Woo; Park, Suyeon; Parnell, Winsome R.; Parsaeian, Mahboubeh; Pascanu, Ionela M.; Pasquet, Patrick; Patel, Nikhil D.; Pattussi, Marcos; Pavlyshyn, Halyna; Pechlaner, Raimund; Pećin, Ivan; Pednekar, Mangesh S.; Pedro, João M.; Peer, Nasheeta; Peixoto, Sergio Viana; Peltonen, Markku; Pereira, Alexandre C.; Peres, Marco A.; Pérez, Cynthia M.; Peterkova, Valentina; Peters, Annette; Petersmann, Astrid; Petkeviciene, Janina; Petrauskiene, Ausra; Kovtun, Olga Petrovna; Pettenuzzo, Emanuela; Peykari, Niloofar; Pfeiffer, Norbert; Phall, Modou Cheyassin; Pham, Son Thai; Pichardo, Rafael N.; Pierannunzio, Daniela; Pigeot, Iris; Pikhart, Hynek; Pilav, Aida; Pilotto, Lorenza; Pistelli, Francesco; Pitakaka, Freda; Piwonska, Aleksandra; Pizarro, Andreia N.; Plans-Rubió, Pedro; Platonova, Alina G.; Poh, Bee Koon; Pohlabeln, Hermann; Polka, Nadija S.; Pop, Raluca M.; Popovic, Stevo R.; Porta, Miquel; Posch, Georg; Poudyal, Anil; Poulimeneas, Dimitrios; Pouraram, Hamed; Pourfarzi, Farhad; Pourshams, Akram; Poustchi, Hossein; Pradeepa, Rajendra; Price, Alison J.; Price, Jacqueline F.; Prista, Antonio; Providencia, Rui; Puder, Jardena J.; Pudule, Iveta; Puiu, Maria; Punab, Margus; Qadir, Muhammed S.; Qasrawi, Radwan F.; Qorbani, Mostafa; Quintana, Hedley K.; Quiroga-Padilla, Pedro J.; Bao, Tran Quoc; Rach, Stefan; Radic, Ivana; Radisauskas, Ricardas; Rahimikazerooni, Salar; Rahman, Mahfuzar; Rahman, Mahmudur; Raitakari, Olli; Raj, Manu; Rajabov, Tamerlan; Rakhmatulloev, Sherali; Rakovac, Ivo; Rao, Sudha Ramachandra; Ramachandran, Ambady; Ramadan, Otim P. C.; Ramires, Virgílio V.; Ramke, Jacqueline; Ramos, Elisabete; Ramos, Rafel; Rampal, Lekhraj; Rampal, Sanjay; Rangelova, Lalka S.; Rarra, Vayia; Rascon-Pacheco, Ramon A.; Rech, Cassiano Ricardo; Redon, Josep; Reganit, Paul Ferdinand M.; Regecová, Valéria; Renner, Jane D. P.; Repasy, Judit A.; Reuter, Cézane P.; Revilla, Luis; Rezaianzadeh, Abbas; Rho, Yeunsook; Ribas-Barba, Lourdes; Ribeiro, Robespierre; Riboli, Elio; Richter, Adrian; Rigo, Fernando; Rigotti, Attilio; Rinaldo, Natascia; Rinke de Wit, Tobias F.; Rito, Ana I.; Ritti-Dias, Raphael M.; Rivera, Juan A.; Roa, Reina G.; Robinson, Louise; Robitaille, Cynthia; Roccaldo, Romana; Rodrigues, Daniela; Rodríguez-Artalejo, Fernando; del Cristo Rodriguez-Perez, María; Rodríguez-Villamizar, Laura A.; Rodríguez, Andrea Y.; Roggenbuck, Ulla; Rohloff, Peter; Rohner, Fabian; Rojas-Martinez, Rosalba; Rojroongwasinkul, Nipa; Romaguera, Dora; Romeo, Elisabetta L.; Rosario, Rafaela V.; Rosengren, Annika; Rouse, Ian; Rouzier, Vanessa; Roy, Joel G. R.; Ruano, Maira H.; Rubinstein, Adolfo; Rühli, Frank J.; Ruidavets, Jean-Bernard; Ruiz-Betancourt, Blanca Sandra; Ruiz-Castell, Maria; Moreno, Emma Ruiz; Rusakova, Iuliia A.; Jonsson, Kenisha Russell; Russo, Paola; Rust, Petra; Rutkowski, Marcin; Saamel, Marge; Sabanayagam, Charumathi; Sabbaghi, Hamideh; Sacchini, Elena; Sachdev, Harshpal S.; Sadjadi, Alireza; Safarpour, Ali Reza; Safi, Sare; Safiri, Saeid; Saghi, Mohammad Hossien; Saidi, Olfa; Saki, Nader; Šalaj, Sanja; Salanave, Benoit; Martinez, Eduardo Salazar; Saleva, Calogero; Salmerón, Diego; Salomaa, Veikko; Salonen, Jukka T.; Salvetti, Massimo; Samoutian, Margarita; Sánchez-Abanto, Jose; Rodríguez, Inés Sánchez; Sandjaja, NN; Sans, Susana; Marina, Loreto Santa; Santacruz, Ethel; Santos, Diana A.; Santos, Ina S.; Santos, Lèlita C.; Santos, Maria Paula; Santos, Osvaldo; Santos, Rute; Santos, Tamara R.; Saramies, Jouko L.; Sardinha, Luis B.; Sarrafzadegan, Nizal; Sathish, Thirunavukkarasu; Saum, Kai-Uwe; Savva, Savvas; Savy, Mathilde; Sawada, Norie; Sbaraini, Mariana; Scazufca, Marcia; Schaan, Beatriz D.; Rosario, Angelika Schaffrath; Schargrodsky, Herman; Schienkiewitz, Anja; Schindler, Karin; Schipf, Sabine; Schmidt, Carsten O.; Schmidt, Ida Maria; Schneider, Andrea; Schnohr, Peter; Schöttker, Ben; Schramm, Sara; Schramm, Stine; Schröder, Helmut; Schultsz, Constance; Schulze, Matthias B.; Schutte, Aletta E.; Sebert, Sylvain; Sedaghattalab, Moslem; Selamat, Rusidah; Sember, Vedrana; Sen, Abhijit; Senbanjo, Idowu O.; Sepanlou, Sadaf G.; Sequera, Guillermo; Serra-Majem, Luis; Servais, Jennifer; Ševčíková, Ľudmila; Shalnova, Svetlana; Shamah-Levy, Teresa; Shamshirgaran, Seyed Morteza; Shanthirani, Coimbatore Subramaniam; Sharafkhah, Maryam; Sharma, Sanjib K.; Shaw, Jonathan E.; Shayanrad, Amaneh; Shayesteh, Ali Akbar; Shengelia, Lela; Shi, Zumin; Shibuya, Kenji; Shimizu-Furusawa, Hana; Shimony, Tal; Shiri, Rahman; Shrestha, Namuna; Si-Ramlee, Khairil; Siani, Alfonso; Siantar, Rosalynn; Sibai, Abla M.; Sidossis, Labros S.; Silitrari, Natalia; Silva, Antonio M.; de Moura Silva, Caroline Ramos; Silva, Diego Augusto Santos; Silva, Kelly S.; Sim, Xueling; Simon, Mary; Simons, Judith; Simons, Leon A.; Sjöberg, Agneta; Sjöström, Michael; Skoblina, Natalia A.; Skodje, Gry Irene; Slazhnyova, Tatyana; Slowikowska-Hilczer, Jolanta; Slusarczyk, Przemysław; Smeeth, Liam; So, Hung-Kwan; Soares, Fernanda Cunha; Sobek, Grzegorz; Sobngwi, Eugène; Sodemann, Morten; Söderberg, Stefan; Soekatri, Moesijanti Y. E.; Soemantri, Agustinus; Sofat, Reecha; Solfrizzi, Vincenzo; Somi, Mohammad Hossein; Sonestedt, Emily; Song, Yi; Soofi, Sajid; Sørensen, Thorkild I. A.; Sørgjerd, Elin Pettersen; Jérome, Charles Sossa; Soto-Rojas, Victoria E.; Soumaré, Aïcha; Sousa-Poza, Alfonso; Sovic, Slavica; Sparboe-Nilsen, Bente; Sparrenberger, Karen; Spencer, Phoebe R.; Spinelli, Angela; Spiroski, Igor; Staessen, Jan A.; Stamm, Hanspeter; Staub, Kaspar; Stavreski, Bill; Steene-Johannessen, Jostein; Stehle, Peter; Stein, Aryeh D.; Stergiou, George S.; Stessman, Jochanan; Stevanović, Ranko; Stieber, Jutta; Stöckl, Doris; Stokwiszewski, Jakub; Stoyanova, Ekaterina; Stratton, Gareth; Stronks, Karien; Strufaldi, Maria Wany; Sturua, Lela; Suárez-Medina, Ramón; Suka, Machi; Sun, Chien-An; Sun, Liang; Sundström, Johan; Sung, Yn-Tz; Sunyer, Jordi; Suriyawongpaisal, Paibul; Sweis, Nabil William G.; Swinburn, Boyd A.; Sy, Rody G.; Sylva, René Charles; Szklo, Moyses; Szponar, Lucjan; Tabone, Lorraine; Tai, E. Shyong; Tambalis, Konstantinos D.; Tammesoo, Mari-Liis; Tamosiunas, Abdonas; Tan, Eng Joo; Tang, Xun; Tanrygulyyeva, Maya; Tanser, Frank; Tao, Yong; Tarawneh, Mohammed Rasoul; Tarp, Jakob; Tarqui-Mamani, Carolina B.; Braunerová, Radka Taxová; Taylor, Anne; Taylor, Julie; Tchibindat, Félicité; te Velde, Saskia J.; Tebar, William R.; Tell, Grethe S.; Tello, Tania; Tham, Yih Chung; Thankappan, K.R.; Theobald, Holger; Theodoridis, Xenophon; Thomas, Nihal; Thorand, Barbara; Thuesen, Betina H.; Tichá, Ľubica; Timmermans, Erik J.; Tjandrarini, Dwi H.; Tjonneland, Anne; Tolonen, Hanna K.; Tolstrup, Janne S.; Topbas, Murat; Topór-Mądry, Roman; Torheim, Liv Elin; Tormo, María José; Tornaritis, Michael J.; Torrent, Maties; Torres-Collado, Laura; Toselli, Stefania; Touloumi, Giota; Traissac, Pierre; Tran, Thi Tuyet-Hanh; Tremblay, Mark S.; Triantafyllou, Areti; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Trinh, Oanh T. H.; Trivedi, Atul; Tsao, Yu-Hsiang; Tshepo, Lechaba; Tsigga, Maria; Tsintavis, Panagiotis; Tsugane, Shoichiro; Tuitele, John; Tuliakova, Azaliia M.; Tulloch-Reid, Marshall K.; Tullu, Fikru; Tuomainen, Tomi-Pekka; Tuomilehto, Jaakko; Turley, Maria L.; Twig, Gilad; Tynelius, Per; Tzala, Evangelia; Tzotzas, Themistoklis; Tzourio, Christophe; Ueda, Peter; Ugel, Eunice; Ukoli, Flora A. M.; Ulmer, Hanno; Unal, Belgin; Usupova, Zhamyila; Uusitalo, Hannu M. T.; Uysal, Nalan; Vaitkeviciute, Justina; Valdivia, Gonzalo; Vale, Susana; Valvi, Damaskini; van Dam, Rob M.; van den Born, Bert-Jan; Van der Heyden, Johan; van der Schouw, Yvonne T.; Van Herck, Koen; Van Lippevelde, Wendy; Van Minh, Hoang; Van Schoor, Natasja M.; van Valkengoed, Irene G. M.; Vanderschueren, Dirk; Vanuzzo, Diego; Varbo, Anette; Varela-Moreiras, Gregorio; Vargas, Luz Nayibe; Varona-Pérez, Patricia; Vasan, Senthil K.; Vasques, Daniel G.; Vega, Tomas; Veidebaum, Toomas; Velasquez-Melendez, Gustavo; Velika, Biruta; Verloigne, Maïté; Veronesi, Giovanni; Verschuren, W. M. Monique; Victora, Cesar G.; Viegi, Giovanni; Viet, Lucie; Vik, Frøydis Nordgård; Vilar, Monica; Villalpando, Salvador; Vioque, Jesus; Virtanen, Jyrki K.; Visvikis-Siest, Sophie; Viswanathan, Bharathi; Vladulescu, Mihaela; Vlasoff, Tiina; Vocanec, Dorja; Vollenweider, Peter; Völzke, Henry; Voutilainen, Ari; Vrijheid, Martine; Vrijkotte, Tanja G. M.; Wade, Alisha N.; Waldhör, Thomas; Walton, Janette; Wambiya, Elvis O. A.; Bebakar, Wan Mohamad Wan; Mohamud, Wan Nazaimoon Wan; de Souza Wanderley Júnior, Rildo; Wang, Ming-Dong; Wang, Ningli; Wang, Qian; Wang, Xiangjun; Wang, Ya Xing; Wang, Ying-Wei; Wannamethee, S. Goya; Wareham, Nicholas; Weber, Adelheid; Webster-Kerr, Karen; Wedderkopp, Niels; Weghuber, Daniel; Wei, Wenbin; Weres, Aneta; Werner, Bo; Westbury, Leo D.; Whincup, Peter H.; Wickramasinghe, Kremlin; Widhalm, Kurt; Widyahening, Indah S.; Więcek, Andrzej; Wild, Philipp S.; Wilks, Rainford J.; Willeit, Johann; Willeit, Peter; Williams, Julianne; Wilsgaard, Tom; Wojciech, Rusek; Wojtyniak, Bogdan; Wolf, Kathrin; Wong-McClure, Roy A.; Wong, Andrew; Wong, Emily B.; Wong, Jyh Eiin; Wong, Tien Yin; Woo, Jean; Woodward, Mark; Wu, Frederick C.; Wu, Hon-Yen; Wu, Jianfeng; Wu, Li Juan; Wu, Shouling; Wyszyńska, Justyna; Xu, Haiquan; Xu, Liang; Yaacob, Nor Azwany; Yamborisut, Uruwan; Yan, Weili; Yang, Ling; Yang, Xiaoguang; Yang, Yang; Yardim, Nazan; Yasuharu, Tabara; García, Martha Yépez; Yiallouros, Panayiotis K.; Yngve, Agneta; Yoosefi, Moein; Yoshihara, Akihiro; You, Qi Sheng; You, San-Lin; Younger-Coleman, Novie O.; Yu, Yu-Ling; Yu, Yunjiang; Yusof, Safiah Md; Yusoff, Ahmad Faudzi; Zaccagni, Luciana; Zafiropulos, Vassilis; Zainuddin, Ahmad A.; Zakavi, Seyed Rasoul; Zamani, Farhad; Zambon, Sabina; Zampelas, Antonis; Zamrazilová, Hana; Zapata, Maria Elisa; Zargar, Abdul Hamid; Zaw, Ko Ko; Zayed, Ayman A.; Zdrojewski, Tomasz; Żegleń, Magdalena; Zejglicova, Kristyna; Vrkic, Tajana Zeljkovic; Zeng, Yi; Zhang, Luxia; Zhang, Zhen-Yu; Zhao, Dong; Zhao, Ming-Hui; Zhao, Wenhua; Zhecheva, Yanitsa V.; Zhen, Shiqi; Zheng, Wei; Zheng, Yingfeng; Zholdin, Bekbolat; Zhou, Maigeng; Zhu, Dan; Zins, Marie; Zitt, Emanuel; Zocalo, Yanina; Zoghlami, Nada; Cisneros, Julio Zuñiga; Zuziak, Monika; Bhutta, Zulfiqar A.; Black, Robert E.; Ezzati, Majid (Peer reviewed; Journal article, 2023)Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1,2,3,4,5,6. Here we used data from 2,325 population-based studies, with measurements of height and weight from ... -
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, Stavroula; Graham, Sarah E.; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; Zhu, Xiang; Clarke, Shoa L.; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J M; Wu, Kuan-Han H; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chikashi; Kanai, Masahiro; Zhou, Wei; Brumpton, Ben Michael; Rasheed, Humaira; Havulinna, Aki S.; Veturi, Yogasudha; Pacheco, Jennifer Allen; Rosenthal, Elisabeth A.; Lingren, Todd; Feng, QiPing; Kullo, Iftikhar J.; Narita, Akira; Takayama, Jun; Martin, Hilary C.; Hunt, Karen A.; Trivedi, Bhavi; Haessler, Jeffrey; Giulianini, Franco; Bradford, Yuki; Miller, Jason E.; Campbell, Archie; Lin, Kuang; Millwood, Iona Y.; Rasheed, Asif; Hindy, George; Faul, Jessica D.; Zhao, Wei; Weir, David R.; Turman, Constance; 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Ruotsalainen, Sanni E.; Daw, EWarwick; Zmuda, Joseph M.; Mitchell, Jonathan S.; Fuchsberger, Christian; Christensen, Henry; Brody, Jennifer A.; Vazquez-Moreno, Miguel; Feitosa, Mary F.; Wojczynski, Mary K.; Wang, Zhe; Preuss, Michael H.; Mangino, Massimo; Christofidou, Paraskevi; Verweij, Niek; Benjamins, Jan W.; Engmann, Jorgen; Tsao, Noah L.; Verma, Anurag; Slieker, Roderick C.; Lo, Ken Sin; Zilhao, Nuno R.; Le, Phuong; Kleber, Marcus E.; Delgado, Graciela E.; Huo, Shaofeng; Ikeda, Daisuke D.; Iha, Hiroyuki; Yang, Jian; Liu, Jun; Demirkan, Ayşe; Leonard, Hampton L.; Marten, Jonathan; Frank, Mirjam; Schmidt, Börge; Smyth, Laura J.; Cañadas-Garre, Marisa; Wang, Chaolong; Nakatochi, Masahiro; Wong, Andrew; Hutri-Kähönen, Nina; Sim, Xueling; Xia, Rui; Huerta-Chagoya, Alicia; Fernandez-Lopez, Juan Carlos; Lyssenko, Valeriya; Nongmaithem, Suraj S.; Bayyana, Swati; Stringham, Heather M.; Irvin, Marguerite R.; Oldmeadow, Christopher; Kim, Han-Na; Ryu, Seungho; Timmers, Paul R H J; Arbeeva, Liubov; 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(Peer reviewed; Journal article, 2022)Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding ...