dc.contributor.author | Gorski, Mathias | |
dc.contributor.author | Rasheed, Humaira | |
dc.contributor.author | Teumer, Alexander | |
dc.contributor.author | Thomas, Laurent | |
dc.contributor.author | Graham, Sarah E. | |
dc.contributor.author | Sveinbjornsson, Gardar | |
dc.contributor.author | Winkler, Thomas W. | |
dc.contributor.author | Günther, Felix | |
dc.contributor.author | Stark, Klaus J. | |
dc.contributor.author | Chai, Jin-Fang | |
dc.contributor.author | Tayo, Bamidele O. | |
dc.contributor.author | Wuttke, Matthias | |
dc.contributor.author | Li, Yong | |
dc.contributor.author | Tin, Adrienne | |
dc.contributor.author | Ahluwalia, Tarunveer S. | |
dc.contributor.author | Ärnlöv, Johan | |
dc.contributor.author | Åsvold, Bjørn Olav | |
dc.contributor.author | Bakker, Stephan J.L. | |
dc.contributor.author | Banas, Bernhard | |
dc.contributor.author | Bansal, Nisha | |
dc.contributor.author | Biggs, Mary L. | |
dc.contributor.author | Biino, Ginevra | |
dc.contributor.author | Böhnke, Michael | |
dc.contributor.author | Boerwinkle, Eric | |
dc.contributor.author | Bottinger, Erwin P. | |
dc.contributor.author | Brenner, Hermann | |
dc.contributor.author | Brumpton, Ben Michael | |
dc.contributor.author | Carroll, Robert J. | |
dc.contributor.author | Chaker, Layal | |
dc.contributor.author | Chalmers, John | |
dc.contributor.author | Chee, Miao-Li | |
dc.contributor.author | Chee, Miao-Ling | |
dc.contributor.author | Cheng, Ching-Yu | |
dc.contributor.author | Chu, Audrey Y. | |
dc.contributor.author | Ciullo, Marina | |
dc.contributor.author | Cocca, Massimiliano | |
dc.contributor.author | Cook, James P. | |
dc.contributor.author | Coresh, Josef | |
dc.contributor.author | Cusi, Daniele | |
dc.contributor.author | de Borst, Martin H. | |
dc.contributor.author | Degenhardt, Frauke | |
dc.contributor.author | Eckardt, Kai-Uwe | |
dc.contributor.author | Endlich, Karlhans | |
dc.contributor.author | Evans, Michele K. | |
dc.contributor.author | Feitosa, Mary F. | |
dc.contributor.author | Franke, Andre | |
dc.contributor.author | Freitag-Wolf, Sandra | |
dc.contributor.author | Fuchsberger, Christian | |
dc.contributor.author | Gampawar, Piyush | |
dc.contributor.author | Gansevoort, Ron T. | |
dc.contributor.author | Ghanbari, Mohsen | |
dc.contributor.author | Ghasemi, Sahar | |
dc.contributor.author | Giedraitis, Vilmantas | |
dc.contributor.author | Gieger, Christian | |
dc.contributor.author | Gudbjartsson, Daniel F. | |
dc.contributor.author | Hallan, Stein | |
dc.contributor.author | Hamet, Pavel | |
dc.contributor.author | Hishida, Asahi | |
dc.contributor.author | Ho, Kevin | |
dc.contributor.author | Hofer, Edith | |
dc.contributor.author | Holleczek, Bernd | |
dc.contributor.author | Holm, Hilma | |
dc.contributor.author | Hoppmann, Anselm | |
dc.contributor.author | Horn, Katrin | |
dc.contributor.author | Hutri-Kähönen, Nina | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Hwang, Shih-Jen | |
dc.contributor.author | Ikram, M. Arfan | |
dc.contributor.author | Josyula, Navya Shilpa | |
dc.contributor.author | Jung, Bettina | |
dc.contributor.author | Kähönen, Mika | |
dc.contributor.author | Karabegović, Irma | |
dc.contributor.author | Khor, Chiea-Chuen | |
dc.contributor.author | Koenig, Wolfgang | |
dc.contributor.author | Kramer, Holly | |
dc.contributor.author | Krämer, Bernhard K. | |
dc.contributor.author | Kühnel, Brigitte | |
dc.contributor.author | Kuusisto, Johanna | |
dc.contributor.author | Laakso, Markku | |
dc.contributor.author | Lange, Leslie A. | |
dc.contributor.author | Lehtimäki, Terho | |
dc.contributor.author | Li, Man | |
dc.contributor.author | Lieb, Wolfgang | |
dc.contributor.author | Lind, Lars | |
dc.contributor.author | Lindgren, Cecilia M. | |
dc.contributor.author | Loos, Ruth J.F. | |
dc.contributor.author | Lukas, Mary Ann | |
dc.contributor.author | Lyytikäinen, Leo-Pekka | |
dc.contributor.author | Mahajan, Anubha | |
dc.contributor.author | Matias-Garcia, Pamela R. | |
dc.contributor.author | Meisinger, Christa | |
dc.contributor.author | Meitinger, Thomas | |
dc.contributor.author | Melander, Olle | |
dc.contributor.author | Milaneschi, Yuri | |
dc.contributor.author | Mishra, Pashupati P. | |
dc.contributor.author | Mononen, Nina | |
dc.contributor.author | Morris, Andrew P. | |
dc.contributor.author | Mychaleckyj, Josyf C. | |
dc.contributor.author | Nadkarni, Girish N. | |
dc.contributor.author | Naito, Mariko | |
dc.contributor.author | Nakatochi, Masahiro | |
dc.contributor.author | Nalls, Mike A. | |
dc.contributor.author | Nauck, Matthias | |
dc.contributor.author | Nikus, Kjell | |
dc.contributor.author | Ning, Boting | |
dc.contributor.author | Nolte, Ilja M. | |
dc.contributor.author | Nutile, Teresa | |
dc.contributor.author | O'Donoghue, Michelle L. | |
dc.contributor.author | O'Connell, Jeffrey | |
dc.contributor.author | Olafsson, Isleifur | |
dc.contributor.author | Orho-Melander, Marju | |
dc.contributor.author | Parsa, Afshin | |
dc.contributor.author | Pendergrass, Sarah A. | |
dc.contributor.author | Penninx, Brenda W.J.H. | |
dc.contributor.author | Pirastu, Mario | |
dc.contributor.author | Preuss, Michael H. | |
dc.contributor.author | Psaty, Bruce M. | |
dc.contributor.author | Raffield, Laura M. | |
dc.contributor.author | Raitakari, Olli T. | |
dc.contributor.author | Rheinberger, Myriam | |
dc.contributor.author | Rice, Kenneth M. | |
dc.contributor.author | Rizzi, Federica | |
dc.contributor.author | Rosenkranz, Alexander R. | |
dc.contributor.author | Rossing, Peter | |
dc.contributor.author | Rotter, Jerome I. | |
dc.contributor.author | Ruggiero, Daniela | |
dc.contributor.author | Ryan, Kathleen A. | |
dc.contributor.author | Sabanayagam, Charumathi | |
dc.contributor.author | Salvi, Erika | |
dc.contributor.author | Schmidt, Helena | |
dc.contributor.author | Schmidt, Reinhold | |
dc.contributor.author | Scholz, Markus | |
dc.contributor.author | Schöttker, Ben | |
dc.contributor.author | Schulz, Christina-Alexandra | |
dc.contributor.author | Sedaghat, Sanaz | |
dc.contributor.author | Shaffer, Christian M. | |
dc.contributor.author | Sieber, Karsten B. | |
dc.contributor.author | Sim, Xueling | |
dc.contributor.author | Sims, Mario | |
dc.contributor.author | Snieder, Harold | |
dc.contributor.author | Stanzick, Kira J. | |
dc.contributor.author | Thorsteinsdottir, Unnur | |
dc.contributor.author | Stocker, Hannah | |
dc.contributor.author | Strauch, Konstantin | |
dc.contributor.author | Stringham, Heather M. | |
dc.contributor.author | Sulem, Patrick | |
dc.contributor.author | Szymczak, Silke | |
dc.contributor.author | Taylor, Kent D. | |
dc.contributor.author | Thio, Chris H.L. | |
dc.contributor.author | Tremblay, Johanne | |
dc.contributor.author | Vaccargiu, Simona | |
dc.contributor.author | van der Harst, Pim | |
dc.contributor.author | van der Most, Peter J. | |
dc.contributor.author | Verweij, Niek | |
dc.contributor.author | Völker, Uwe | |
dc.contributor.author | Wakai, Kenji | |
dc.contributor.author | Waldenberger, Melanie | |
dc.contributor.author | Wallentin, Lars | |
dc.contributor.author | Wallner, Stefan | |
dc.contributor.author | Wang, Judy | |
dc.contributor.author | Waterworth, Dawn M. | |
dc.contributor.author | White, Harvey D. | |
dc.contributor.author | Willer, Cristen J. | |
dc.contributor.author | Wong, Tien-Yin | |
dc.contributor.author | Woodward, Mark | |
dc.contributor.author | Yang, Qiong | |
dc.contributor.author | Yerges-Armstrong, Laura M. | |
dc.contributor.author | Zimmermann, Martina | |
dc.contributor.author | Zonderman, Alan B. | |
dc.contributor.author | Bergler, Tobias | |
dc.contributor.author | Stefansson, Kari | |
dc.contributor.author | Böger, Carsten A. | |
dc.contributor.author | Pattaro, Cristian | |
dc.contributor.author | Köttgen, Anna | |
dc.contributor.author | Kronenberg, Florian | |
dc.contributor.author | Heid, Iris M. | |
dc.date.accessioned | 2023-02-06T14:18:33Z | |
dc.date.available | 2023-02-06T14:18:33Z | |
dc.date.created | 2022-08-23T13:02:55Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Kidney International. 2022, 102 (3), 624-639. | en_US |
dc.identifier.issn | 0085-2538 | |
dc.identifier.uri | https://hdl.handle.net/11250/3048644 | |
dc.description.abstract | Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genome-wide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR-baseline (11 novel, one known for this phenotype), including nine variants robustly associated across models were identified. All loci for eGFR-decline were known for cross-sectional eGFR and thus distinguished a subgroup of eGFR loci. Seven of the nine variants showed variant-by-age interaction on eGFR cross section (further about 350,000 individuals), which linked genetic associations for eGFR-decline with age-dependency of genetic cross-section associations. Clinically important were two to four-fold greater genetic effects on eGFR-decline in high-risk subgroups. Five variants associated also with chronic kidney disease progression mapped to genes with functional in-silico evidence (UMOD, SPATA7, GALNTL5, TPPP). An unfavorable versus favorable nine-variant genetic profile showed increased risk odds ratios of 1.35 for kidney failure (95% confidence intervals 1.03-1.77) and 1.27 for acute kidney injury (95% confidence intervals 1.08-1.50) in over 2000 cases each, with matched controls). Thus, we provide a large data resource, genetic loci, and prioritized genes for kidney function decline, which help inform drug development pipelines revealing important insights into the age-dependency of kidney function genetics. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies | en_US |
dc.title.alternative | Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | 624-639 | en_US |
dc.source.volume | 102 | en_US |
dc.source.journal | Kidney International | en_US |
dc.source.issue | 3 | en_US |
dc.identifier.doi | 10.1016/j.kint.2022.05.021 | |
dc.identifier.cristin | 2045322 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |