dc.contributor.author | Stokland, Ann-Elin Meling | |
dc.contributor.author | Ueland, Grethe Åstrøm | |
dc.contributor.author | Lima, Kari | |
dc.contributor.author | Grønning, Kaja | |
dc.contributor.author | Finnes, Trine Elisabeth | |
dc.contributor.author | Svendsen, Margrethe | |
dc.contributor.author | Tomkowicz, Aneta Ewa | |
dc.contributor.author | Holte, Synnøve Emblem | |
dc.contributor.author | Sollid, Stina Therese | |
dc.contributor.author | Debowska, Aleksandra | |
dc.contributor.author | Singsås, Hallvard | |
dc.contributor.author | Rensvik, Marthe Landsverk | |
dc.contributor.author | Lejon, Helle | |
dc.contributor.author | Sørmo, Dag-Erik | |
dc.contributor.author | Svare, Anders | |
dc.contributor.author | Blika, Sigrid | |
dc.contributor.author | Milova, Petya | |
dc.contributor.author | Korsgaard, Elin | |
dc.contributor.author | Husby, Øystein | |
dc.contributor.author | Breivik, Lars Ertesvåg | |
dc.contributor.author | Jørgensen, Anders Palmstrøm | |
dc.contributor.author | Husebye, Eystein Sverre | |
dc.date.accessioned | 2023-01-20T13:47:27Z | |
dc.date.available | 2023-01-20T13:47:27Z | |
dc.date.created | 2022-03-08T14:05:21Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism (JCEM). 2022, 107 (6), e2331-e2338. | en_US |
dc.identifier.issn | 0021-972X | |
dc.identifier.uri | https://hdl.handle.net/11250/3044999 | |
dc.description.abstract | Context - Autoimmune thyroid disease is the most common endocrine comorbidity in autoimmune Addison disease (AAD), but detailed investigations of prevalence and clinical course are lacking.
Objective - This work aimed to provide comprehensive epidemiological and clinical data on autoimmune thyroid disorders in AAD.
Methods - A nationwide registry-based study including 442 patients with AAD and autoimmune thyroid disease were identified through the Norwegian National Registry of Autoimmune Diseases.
Results - Of 912 registered AAD patients, 442 (48%) were diagnosed with autoimmune thyroid disease. A total of 380 (42%) had autoimmune hypothyroidism. Of the 203 with available thyroid function tests at time of diagnosis, 20% had overt hypothyroidism, 73% had subclinical hypothyroidism, and 7% had thyroid levels in the normal range. Negative thyroid peroxidase antibodies was found in 32%. Ninety-eight percent were treated with levothyroxine, 5% with combination therapy with liothyronine or thyroid extracts, and 1% were observed without treatment. Seventy-eight patients (9%) were diagnosed with Graves disease (GD), of whom 16 (21%) were diagnosed with autoimmune hypothyroidism either before onset or after remission of GD. At the end of follow-up, 33% had normal thyroid hormone levels without antithyroid-drugs or levothyroxine treatment. The remaining had either active disease (5%), had undergone ablative treatment (41%), or had developed autoimmune hypothyroidism (21%).
Conclusion - The true prevalence of hypothyroidism in AAD is lower than reported in the current literature. Careful consideration of the indication to start thyroxin therapy is warranted. Long-term remission rates in GD patients with AAD are comparable to recent reports on long-term follow-up of patients without AAD. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Oxford Academic | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/deed.no | * |
dc.title | Autoimmune Thyroid Disorders in Autoimmune Addison´s Disease | en_US |
dc.title.alternative | Autoimmune Thyroid Disorders in Autoimmune Addison´s Disease | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.source.pagenumber | e2331-e2338 | en_US |
dc.source.volume | 107 | en_US |
dc.source.journal | Journal of Clinical Endocrinology and Metabolism (JCEM) | en_US |
dc.source.issue | 6 | en_US |
dc.identifier.doi | 10.1210/clinem/dgac089 | |
dc.identifier.cristin | 2008290 | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |