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dc.contributor.authorBorgen, Tove Tveitan
dc.contributor.authorBjørnerem, Åshild
dc.contributor.authorSolberg, Lene Bergendal
dc.contributor.authorAndreasen, Camilla
dc.contributor.authorFigved, Wender
dc.contributor.authorHübschle, Lars Michael
dc.contributor.authorStenbro, May-Britt
dc.contributor.authorBasso, Trude
dc.contributor.authorDahl, cecilie
dc.contributor.authorStutzer, Jens-Meinhard
dc.contributor.authorFrihagen, Frede
dc.contributor.authorEriksen, Erik Fink
dc.contributor.authorNordsletten, Lars
dc.contributor.authorHansen, Ann Kristin
dc.contributor.authorApalset, Ellen Margrete
dc.contributor.authorGjertsen, Jan Erik
dc.contributor.authorLund, Ida
dc.date.accessioned2022-11-29T13:52:56Z
dc.date.available2022-11-29T13:52:56Z
dc.date.created2020-01-07T17:36:47Z
dc.date.issued2019
dc.identifier.citationOsteoporosis International. 2019, 1-10.en_US
dc.identifier.issn0937-941X
dc.identifier.urihttps://hdl.handle.net/11250/3034786
dc.description.abstractSummary - Determinants of trabecular bone score (TBS) and vertebral fractures assessed semiquantitatively (SQ1–SQ3) were studied in 496 women with fragility fractures. TBS was associated with age, parental hip fracture, alcohol intake and BMD, not SQ1–SQ3 fractures. SQ1–SQ3 fractures were associated with age, prior fractures, and lumbar spine BMD, but not TBS. Introduction - Trabecular bone score (TBS) and vertebral fractures assessed by semiquantitative method (SQ1–SQ3) seem to reflect different aspects of bone strength. We therefore sought to explore the determinants of and the associations between TBS and SQ1–SQ3 fractures. Methods - This cross-sectional sub-study of the Norwegian Capture the Fracture Initiative included 496 women aged ≥ 50 years with fragility fractures. All responded to a questionnaire about risk factors for fracture, had bone mineral density (BMD) of femoral neck and/or lumbar spine assessed, TBS calculated, and 423 had SQ1–SQ3 fracture assessed. Results - Mean (SD) age was 65.6 years (8.6), mean TBS 1.27 (0.10), and 33.3% exhibited SQ1–SQ3 fractures. In multiple variable analysis, higher age (βper SD = − 0.26, 95% CI: − 0.36,− 0.15), parental hip fracture (β = − 0.29, 95% CI: − 0.54,− 0.05), and daily alcohol intake (β = − 0.43, 95% CI − 0.79, − 0.08) were associated with lower TBS. Higher BMD of femoral neck (βper SD = 0.34, 95% CI 0.25–0.43) and lumbar spine (βper SD = 0.40, 95% CI 0.31–0.48) were associated with higher TBS. In multivariable logistic regression analyses, age (ORper SD = 1.94, 95% CI 1.51–2.46) and prior fragility fractures (OR = 1.71, 95% CI 1.09–2.71) were positively associated with SQ1–SQ3 fractures, while lumbar spine BMD (ORper SD = 0.75 95% CI 0.60–0.95) was negatively associated with SQ1–SQ3 fractures. No association between TBS and SQ1–SQ3 fractures was found. Conclusion - Since TBS and SQ1–SQ3 fractures were not associated, they may act as independent risk factors, justifying the use of both in post-fracture risk assessment.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleDeterminants of trabecular bone score and prevalent vertebral fractures in women with fragility fractures: a cross-sectional sub-study of NoFRACTen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1-10en_US
dc.source.journalOsteoporosis Internationalen_US
dc.identifier.doi10.1007/s00198-019-05215-z
dc.identifier.cristin1768000
cristin.unitcode1920,9,0,0
cristin.unitnameKlinikk for ortopedi, revmatologi og hudsykdommer
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse-Ikkekommersiell 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse-Ikkekommersiell 4.0 Internasjonal