Working Memory Training in Amnestic and Non-amnestic Patients With Mild Cognitive Impairment: Preliminary Findings From Genotype Variants on Training Effects
Hernes, Susanne Miriam Sørensen; Flak, Marianne Møretrø; Løhaugen, Gro Christine Christensen; Skranes, Jon Sverre; Hol, Haakon Ramsland; Madsen, Bengt-Ove; Knapskog, Anne Brita; Engvig, Andreas; Pripp, Are Hugo; Ulstein, Ingun; Lona, Trine Eli.b.; Zhang, Xin; Chang, Linda
Peer reviewed, Journal article
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Date
2021Metadata
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10.3389/fnagi.2021.624253Abstract
Working memory training (WMT) effects may be modulated by mild cognitive impairment (MCI) subtypes, and variations in APOE-epsilon (APOE-ε) and LMX1A genotypes. Sixty-one individuals (41 men/20 women, mean age 66 years) diagnosed with MCI (31 amnestic/30 non-amnestic) and genotyped for APOE-ε and LMX1A completed 4 weeks/20-25 sessions of WMT. Cognitive functions were assessed before, 4 weeks and 16 weeks after WMT. Except for Processing Speed, the non-amnestic MCI group (naMCI) outperformed the amnestic MCI (aMCI) group in all cognitive domains across all time-points. At 4 weeks, working memory function improved in both groups (p