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dc.contributor.authorSofias, Alexandros Marios
dc.contributor.authorBjørkøy, Geir
dc.contributor.authorOchando, Jordi
dc.contributor.authorSønstevold, Linda
dc.contributor.authorHegvik, Maria
dc.contributor.authorDavies, Catharina de Lange
dc.contributor.authorHaraldseth, Olav
dc.contributor.authorLammers, Twan
dc.contributor.authorMulder, Willem J. M.
dc.contributor.authorHak, Sjoerd
dc.date.accessioned2022-10-03T12:52:07Z
dc.date.available2022-10-03T12:52:07Z
dc.date.created2021-09-06T13:00:04Z
dc.date.issued2021
dc.identifier.citationAdvanced Science. 2021, 8 (13), .en_US
dc.identifier.issn2198-3844
dc.identifier.urihttps://hdl.handle.net/11250/3023385
dc.description.abstractActive-targeting nanomedicine formulations have an intricate in vivo behavior. Nanomedicines developed to target endothelial αvβ3-integrin are recently demonstrated to display extensive uptake by circulating phagocytes. These phagocytes show inherent tumor-homing capacities and therefore are capable of actively delivering the endocytosed nanomaterial in lesions. Here, the targeting kinetics and mechanisms of cyclic arginine–glycine–aspartate (cRGD)-decorated lipid nanoparticles (NPs) toward activated vasculature in inflamed lesions during wound healing are studied. The cRGD-NP targeting toward inflamed lesions is identified to be mechanistically similar to the NP accumulation in cancerous lesions. Through a complementary experimental approach, it is observed that circulating phagocytes engage cRGD-NPs and are subsequently homed to the inflamed endothelium. The inflammation-associated phagocytes remain static among endothelial cells upon targeting, resulting in the extensive presence of cRGD-NP-positive phagocytes in the angiogenic vessels. Hence, phagocytic immune cells contribute to cRGD-NP targeting toward angiogenesis. This mechanistic study underlines the need for detailed investigations of NP in vivo behavior. This is critically important for the realization of NPs potential as advanced (immunological) therapeutic agents.en_US
dc.language.isoengen_US
dc.publisherWiley Open Accessen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCyclic Arginine–Glycine–Aspartate-Decorated Lipid Nanoparticle Targeting toward Inflammatory Lesions Involves Hitchhiking with Phagocytesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber10en_US
dc.source.volume8en_US
dc.source.journalAdvanced Scienceen_US
dc.source.issue13en_US
dc.identifier.doi10.1002/advs.202100370
dc.identifier.cristin1931611
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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