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dc.contributor.authorBlix, Egil Støre
dc.contributor.authorKildal, Anders Benjamin
dc.contributor.authorBertelsen, Eirin Listau
dc.contributor.authorWaage, Anders
dc.contributor.authorMyklebust, June
dc.contributor.authorKolstad, Arne
dc.contributor.authorHusebekk, Anne
dc.date.accessioned2022-05-03T09:36:00Z
dc.date.available2022-05-03T09:36:00Z
dc.date.created2015-04-10T09:24:19Z
dc.date.issued2015
dc.identifier.citationBiology of Blood and Marrow Transplantation. 2015, 21 (5), 840-847.en_US
dc.identifier.issn1083-8791
dc.identifier.urihttps://hdl.handle.net/11250/2993843
dc.description.abstractMultiple myeloma (MM) is considered an incurable B cell malignancy, although many patients can benefit from high-dose therapy with autologous stem cell transplantation (ASCT) as a first-line treatment. In non-Hodgkin lymphoma (NHL), ASCT is usually performed after relapse with curative intent. Disease progression is often associated with increased angiogenesis, in which endothelial progenitor cells (EPC) may have a central role. Here, we investigated the clinical impact of EPC levels in peripheral blood stem cell (PBSC) autografts for MM and NHL patients who received ASCT. EPC were identified by flow cytometry as aldehyde dehydrogenasehi CD34+ vascular endothelial growth factor receptor 2+ CD133+ cells in both MM and NHL autografts. In MM, there was a positive correlation between EPC percentage and serum (s)-β2-microglobulin levels (r2 = .371, P = .002). Unlike for NHL patients, MM patients with high numbers of infused EPC (EPC cells per kilogram) during ASCT had significant shorter progression-free survival (PFS) (P = .035), overall survival (P = .044) and time to next treatment (P = .009). In multivariate analysis, EPC cells per kilogram was a significant independent negative prognostic indicator of PFS (P = .03). In conclusion, the presence of high number of EPC in PBSC grafts is associated with adverse prognosis after ASCT in MM.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleContent of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyelomaen_US
dc.title.alternativeContent of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyelomaen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber840-847en_US
dc.source.volume21en_US
dc.source.journalBiology of Blood and Marrow Transplantationen_US
dc.source.issue5en_US
dc.identifier.doi10.1016/j.bbmt.2014.12.027
dc.identifier.cristin1236459
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal